Acta Neurologica Belgica

, Volume 112, Issue 4, pp 327–333 | Cite as

Vitamin D and multiple sclerosis: a critical review and recommendations on treatment

  • Alireza Faridar
  • Ghazaleh Eskandari
  • Mohammad Ali Sahraian
  • Alireza Minagar
  • Amirreza AzimiEmail author
Review Article


Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.


Vitamin D Multiple sclerosis Demyelinating Prevention 



The authors would like to express their gratitude to Professor Abdolmohamad Rostami for constructive comments. We are also so grateful to Ms. Katherine Regan for kindly editing the manuscript.

Conflict of interest



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Copyright information

© Belgian Neurological Society 2012

Authors and Affiliations

  • Alireza Faridar
    • 1
  • Ghazaleh Eskandari
    • 2
  • Mohammad Ali Sahraian
    • 3
  • Alireza Minagar
    • 4
  • Amirreza Azimi
    • 2
    Email author
  1. 1.Department of NeurologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Brain and Spinal Injury Research CenterTehran University of Medical Sciences, Sina HospitalTehranIran
  3. 3.SinaMS Research Center, Brain and Spinal Injury Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Department of NeurologyLSU Health Sciences CenterShreveportUSA

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