Acta Neurologica Belgica

, Volume 113, Issue 1, pp 7–11 | Cite as

Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma

  • George A. AlexiouEmail author
  • George Vartholomatos
  • Achilleas Karamoutsios
  • Anna Batistatou
  • Athanasios P. Kyritsis
  • Spyridon Voulgaris
Original Article


Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45dim/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.


Circulating progenitor cells Glioma Meningioma 


Conflict of interest



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Copyright information

© Belgian Neurological Society 2012

Authors and Affiliations

  • George A. Alexiou
    • 1
    Email author
  • George Vartholomatos
    • 2
  • Achilleas Karamoutsios
    • 2
  • Anna Batistatou
    • 3
  • Athanasios P. Kyritsis
    • 4
  • Spyridon Voulgaris
    • 1
  1. 1.Department of NeurosurgeryUniversity Hospital of IoanninaIoanninaGreece
  2. 2.Unit of Molecular Biology, Haematology LaboratoryUniversity Hospital of IoanninaIoanninaGreece
  3. 3.Department of PathologyUniversity Hospital of IoanninaIoanninaGreece
  4. 4.Department of NeurologyUniversity Hospital of IoanninaIoanninaGreece

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