Acta Neurologica Belgica

, Volume 112, Issue 1, pp 9–13 | Cite as

Therapeutic challenges in a patient with POEMS syndrome and recurrent stroke: presentation of a case and review of the literature

  • Björn SommerEmail author
  • Jens Schaumberg
Review Article


POEMS syndrome includes the clinical features of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. A severe complication of patients with this syndrome is ischemic stroke, which has been described only occasionally despite the hematologic abnormalities that may be associated with the disease. In the literature, only eight patients have been reported as suffering from multiple or recurrent strokes until now. We present a 54-year-old woman from Sri Lanka with POEMS syndrome who experienced recurrent ischemic strokes followed by an acute abdomen and global heart failure. On the basis of a literature review, we discuss current therapeutic approaches and their possible side effects.


POEMS syndrome Ischemic stroke Secondary prophylaxis Polyneuropathy Complication 


Conflict of interest

The authors declare that they have no conflict of interest relevant to this article.


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Copyright information

© Belgian Neurological Society 2012

Authors and Affiliations

  1. 1.Department of NeurosurgeryUniversity of Erlangen-NürnbergErlangenGermany
  2. 2.Department of NeurologyAsklepios Klinik AltonaHamburgGermany

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