Biological Theory

, Volume 8, Issue 4, pp 383–390 | Cite as

Simulating a Model of Metabolic Closure

  • Athel Cornish-Bowden
  • Gabriel Piedrafita
  • Federico Morán
  • María Luz Cárdenas
  • Francisco Montero
Thematic Issue Article: Synthesis (σύνθεσις)

Abstract

The goal of synthetic biology is to create artificial organisms. To achieve this it is essential to understand what life is. Metabolism-replacement systems, or (MR)-systems, constitute a theory of life developed by Robert Rosen, characterized in the statement that organisms are closed to efficient causation, which means that they must themselves produce all the catalysts they need. This theory overlaps in part with other current theories, including autopoiesis, the chemoton, and autocatalytic sets, all of them invoking some idea of closure. A simple model of an (MR)-system has been implemented in the computer, and behaves in ways that may shed light on the requirements for a prebiotic self-organizing system. In addition to a trivial steady state in which nothing happens, it can establish a non-trivial steady state in which all intermediates have finite concentrations, with their rates of degradation balanced by their rates of synthesis. The system can be regenerated from the set of food components plus a single intermediate, and maintain itself in that state indefinitely, despite continuous degradation. At the very low compartment volumes that may have existed in prebiotic conditions, for example in cavities in minerals, or in micelles formed by simple amphiphiles, statistical fluctuations in the numbers of molecules need to be taken into account. With the stochastic approach there is no non-trivial steady state in strict mathematical terms, because the system will always collapse to the trivial state after sufficient time. However, the average time before collapse is so long for volumes greater than \(10^{-19}\;{\textsc{l}}\) (much smaller than the volume of the order of \(10^{-15}\;{\textsc{l}}\) for a typical bacterial cell) that for practical purposes the self-maintaining state of non-null concentrations becomes significant, recalling the situation of bistability that is observed in deterministic analysis. In turn, there exists a minimum size below which the self-organizing system cannot maintain itself on chemically relevant time scales. The value of the critical volume depends on the particular concentrations and rate constants assumed, but the principle could apply generally.

Keywords

Autopoiesis Chemoton Hypercycles Metabolic closure (MR)-systems Self-organization Simulation 

Notes

Acknowledgements

This work was supported by grant BFU2009-12895-C02-02 (Ministerio de Ciencia e Innovación, Spain). GP acknowledges support from PhD scholarship FPU (Formación del Profesorado Universitario, Ministry of Education, Spain). AC-B and MLC were supported by the Centre National de la Recherche Scientifique.

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Copyright information

© Konrad Lorenz Institute for Evolution and Cognition Research 2013

Authors and Affiliations

  • Athel Cornish-Bowden
    • 1
  • Gabriel Piedrafita
    • 2
  • Federico Morán
    • 2
  • María Luz Cárdenas
    • 1
  • Francisco Montero
    • 2
  1. 1.Unité de Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche ScientifiqueAix-Marseille UniversitéMarseilleFrance
  2. 2.Facultad de Ciencias QuímicasUniversidad Complutense de MadridMadridSpain

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