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Nutrafoods

, Volume 12, Issue 3, pp 71–79 | Cite as

Apple biophenol synergistic complex and its potential benefits for cardiovascular health

  • Valentina Bortolotto
  • Cristiana PiangiolinoEmail author
Review

Abstract

Most of cardiovascular disease (CVD) events are caused by risk factors that can be controlled, treated or modified. Amongst these factors are some modifiable ones, such as hypertension, tobacco use, hyperglycaemia and diabetes, physical inactivity, unhealthy diet, cholesterol/lipids, overweight and obesity. Others, such as age, gender and family history, cannot be changed.

Recent clinical trials and epidemiological studies show that prevention, based on lifestyle and social change, starting with conscious and responsible nutrition, aims at delaying the use of drugs in people in high-risk categories.

Based on this concept, we investigated some functional features of an active ingredient, called SelectSIEVE® Apple PCQ. It is composed of purified biophenols from apple, including phloridzin, quercetin and chlorogenic acid. The high antioxidant activity of Apple PCQ® has been tested by the ORAC, DPPH, ABTS and Folin-Ciocalteau assays with respect to pure standard compounds and other commercially available extracts. Furthermore, we observed in vitro the modulation of antioxidant enzymes like superoxide dismutase, catalase and glutathione peroxidase whose activity improved by 22.14%, 31.65% and 18.41% respectively for Apple PCQ® compared to the control. Another in vitro test showed a strong inhibition degree of α-amylase and α-glucosidase enzymes, by 74% and 92% respectively, for Apple PCQ® compared to the control. These results lay the foundations for a potential regulation of glucose metabolism that will be confirmed by clinical studies.

Keywords

apple phloridzin quercetin chlorogenic acid CVD glucose metabolism diabetes 

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Copyright information

© CEC editore - Springer-Verlag Italia 2013

Authors and Affiliations

  1. 1.Principium Europe srlSolaro (MI)Italy

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