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Journal of the Iranian Chemical Society

, Volume 17, Issue 2, pp 319–325 | Cite as

Synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity

  • Amira A. GhoneimEmail author
  • Ahmed F. El-Farargy
  • Nadia A. A. Elkanzi
Original Paper
  • 33 Downloads

Abstract

Reaction of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 with benzoyl isothiocyanate gave 2,3-dihydro-6-phenyl-2-thioxofuro[3,2-d]pyrimidin-4-one. Compound 3 was reacted with benzyl chloride to afford 2-(benzylthio)-6-phenylfuro[3,2-d]pyrimidin-4-one 4 and also reacted with bromoglucopyranosyl to give S-glycoside 5. The cyclization of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 using thiourea, aniline, and carbon disulfide gave phenylfuro[3,2-d]pyrimidine derivatives. The pharmacological properties for the synthesized compounds were reported.

Keywords

Synthesis Benzoyl isothiocyanate Phenylfuro[2,3-d]pyrimidine Glycosides Antimicrobial activities 

Notes

Acknowledgements

The authors thank College of Science, Jouf University, Sakaka, Kingdom of Saudi and Chemistry Department, Faculty of Science, Zagazig University, Zagazig, for helping to bring out this research. A. F. El-Farargy thanks Prof. Dr. N. Krausa, Lehrstuhl für Organische Chemie, TU Dortmund, Germany, for his continuous help and repeated invitation.

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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  1. 1.Chemistry Department, Collage of ScienceJouf UniversitySakakaSaudi Arabia
  2. 2.Chemistry Department, Faculty of ScienceZagazig UniversityZagazigEgypt
  3. 3.Chemistry Department, Faculty of ScienceAswan UniversityAswanEgypt

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