Vitamin C as a green and robust catalyst for the fast and efficient synthesis of valuable organic compounds via multi-component reactions in water
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In the present paper, we report l-ascorbic acid (vitamin C) as an efficient and robust catalyst for the straightforward synthesis of various organic compounds, including carboxamide, benzodiazepine and benzoxazepine derivatives. These compounds with potential drug value which exhibit a broad spectrum biological and pharmacological activities were successfully accessed with vitamin C catalytic system under environmentally friendly conditions in water. The main advantages of this protocol are operational simplicity, mild reaction conditions, high yields in short reaction time and good substrate generality.
KeywordsAscorbic acid Green chemistry Heterocyclic compounds Multi-component reactions
We gratefully acknowledge financial support of the Research Council of Shahid Beheshti University and the Iran National Science Foundation (INSF).
Compliance with ethical standards
Conflicts of interest
All authors declare that they have no conflict of interest.
- 2.D.T. Allen, K.S. Rosselot, Pollution prevention for chemical processes (Wiley-Interscience, Hoboken, 1997)Google Scholar
- 22.S. Arayachukiat, C. Kongtes, A. Barthel, S.V. Vummaleti, A. Poater, S. Wannakao, L. Cavallo, V. D’Elia, A.C.S. Sustain, Chem. Eng. 5, 6392 (2017)Google Scholar
- 29.A. Shaabani, A. Rashidi Vahid, S. Shaabani, R. Mohammadian, M.T. Nazeri, M. Keramati Nejad, Appl. Organomet. Chem. e4510 (2018)Google Scholar