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Utility of 3-benzylidenefuran-2(3H)-one and 3-benzylideneisobenzofuran-1(3H)-one as precursors of biologically active novel heterocycles

  • Naglaa F. H. MahmoudEmail author
  • Maher A. El-Hashash
  • Galal A. Elsayed
Original Paper

Abstract

In the present work, 3-benzylidenefuran 2 and 3-benzylideneisobenzofuran 3 derivatives were investigated in a comparative study in which they were utilized as building blocks to construct different heterocyclic compounds. Therefore, they were allowed to react with different nitrogen and oxygen nucleophiles under the same conditions to afford some novel compounds 4–16. All the structures of the synthesized compounds 2–16 were elucidated based on their elemental analyses and spectral measurements. The bioactivities of the synthesized compounds were evaluated, where some of tested compounds exhibited promising antimicrobial, antitumor, and antioxidant activities.

Keywords

Arylidene Furanone Isobenzofuranone Pyrrolone Spiro Azepintrione 

Notes

Acknowledgements

We would like to thank both the Science and Technology Development Fund of Egypt (STDF) and Department of Chemistry, Faculty of Science, Ain Shams University.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

13738_2018_1553_MOESM1_ESM.docx (3.8 mb)
Supplementary material 1 (DOCX 3878 KB)

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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  • Naglaa F. H. Mahmoud
    • 1
    Email author
  • Maher A. El-Hashash
    • 1
  • Galal A. Elsayed
    • 1
  1. 1.Chemistry Department, Faculty of ScienceAin Shams UniversityCairoEgypt

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