Journal of the Iranian Chemical Society

, Volume 16, Issue 3, pp 629–637 | Cite as

Utilization of thioacetanilides in the synthesis of new 4-(4-acetamidophenylazo)thiophene scaffolds and evaluating their anti-oxidant activity

  • Ehab Abdel-LatifEmail author
  • Eman M. Keshk
  • Abdel-Galil M. Khalil
  • Ali Saeed
  • Heba M. Metwally
Original Paper


The aim of this study involves the synthesis of novel heterocyclic scaffolds containing acetanilide moiety from the readily accessible 2-substituted-2-(4-acetamidophenylhydrazono)-thioacetanilides, which underwent reaction with various alpha-halogenated reagents (namely: bromoacetone, phenacyl bromide, ethyl bromoacetate and chloroacetonitrile) afforded the corresponding thiophene derivatives 5, 7 and 9. All freshly synthesized scaffolds were elucidated by considering the data of both elemental and spectral analyses. The synthesized scaffolds were screened for anti-oxidant activities and showed promising results.


4-Aminoacetanilide Japp–Klingemann Chloroacetonitrile Thiophenes Anti-oxidant activity 


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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceMansoura UniversityMansouraEgypt

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