Journal of the Iranian Chemical Society

, Volume 16, Issue 3, pp 603–608 | Cite as

Cu-catalyzed synthesis of functionalized benzo [1, 3] selenazin from intramolecular C–H activation reactions of isocyanides, aniline-acyl isoselenocyanate adduct

  • Manijeh Nematpour
  • Elham Rezaee
  • Mehdi Jahani
  • Sayyed Abbas TabatabaiEmail author
Original Paper


A novel approach to the synthesis of benzo [1, 3] selenazin derivatives via a one-pot, four-component, intramolecular C–H activation reaction of isocyanides, aniline and acyl isoselenocyanate (generated from acyl chlorides and potassium selenocyanate) is presented. The reaction takes place under mild conditions in the presence of copper (I) iodide in acetone at room temperature with appropriate yields.

Graphical abstract


C–H activation Cu catalyzed Benzo [1, 3] selenazin Isocyanides Acyl isoselenocyanate Aniline 



This work was supported by the Research Council of Shahid Beheshti University of Medical Sciences.


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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  • Manijeh Nematpour
    • 1
  • Elham Rezaee
    • 1
  • Mehdi Jahani
    • 2
  • Sayyed Abbas Tabatabai
    • 1
    Email author
  1. 1.Department of Pharmaceutical Chemistry, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of ChemistrySharif University of TechnologyTehranIran

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