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Journal of the Iranian Chemical Society

, Volume 16, Issue 1, pp 93–100 | Cite as

Risedronate extraction from artificial urine with using monolithic polymer-based anion exchangers

  • Monika ZielińskaEmail author
  • Adam Voelkel
Original Paper
  • 14 Downloads

Abstract

Bisphosphonates are poorly sorbed from the gastrointestinal tract, therefore, the urinary recovery ratio after oral administration is an important parameter to control. Analysis of bisphosphonates in biological samples causes challenges due to their chemical properties. Their high solubility in water and extensive ionization cause that reported tedious sample extraction methods generally involved a combination of multiple extraction steps. Therefore, competitive solution to the conventional sample preparation techniques was proposed in this work. Aminated poly(styrene–divinylbenzene–vinylbenzyl chloride) monoliths and aminated poly(divinylbenzene–vinylbenzyl chloride) were prepared by in situ polymerization in stainless steel needles. Amination of polymerized monolith was carried out by trimethylamine or pyridine. Several research methods were applied to assess the modification of monolithic materials: Energy dispersive X-ray Spectrometry, scanning electron microscope images and Fourier Transform Infrared Spectroscopy. Artificial urine used as simulated body fluid containing sodium risedronate as standard compound was passed through monolithic in-needle extraction (MINE) device. The amount of analyte in eluate solutions was measured using HPLC system. The effectiveness of complete desorption process was over 95% with using potassium phosphate solution (pH 7.8) as eluent.

Keywords

Adsorption Copolymers Anionic polymer synthesis Spectroscopy UV–Vis Bisphosphonate 

Notes

Acknowledgements

This study was funded by the Polish National Science Centre, Grant No. 2013/11/D/ST4/02829.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Institute of Chemical Technology and EngineeringPoznań University of TechnologyPoznanPoland

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