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Journal of the Iranian Chemical Society

, Volume 13, Issue 4, pp 645–651 | Cite as

Catalyst-free and selective oxidation of pyridine derivatives and tertiary amines to corresponding N-oxides with 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane

  • Davood AzarifarEmail author
  • Boshra Mahmoudi
Original Paper

Abstract

The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields.

Graphical abstract

The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields.

Keywords

Oxidation Pyridine-N-oxide 1,2-Diphenyl-1,1,2,2-tetrahydroperoxyethane Catalyst-free 

Notes

Acknowledgments

The authors wish to thank the Research Council of Bu-Ali Sina University for financial support to carry out this research.

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Copyright information

© Iranian Chemical Society 2015

Authors and Affiliations

  1. 1.Faculty of ChemistryBu-Ali Sina UniversityHamedanIran

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