Journal of the Iranian Chemical Society

, Volume 10, Issue 5, pp 1001–1011

Novel 2,2′-bipyridine palladium(II) complexes with glycine derivatives: synthesis, characterization, cytotoxic assays and DNA-binding studies

  • Maryam Saeidifar
  • Hassan Mansouri-Torshizi
  • Adele Divsalar
  • Ali Akbar Saboury
Original Paper


The two water-soluble designed palladium(II) complexes, [Pd(bpy)(pip-Ac)]NO3 and [Pd(bpy)(mor-Ac)]NO3, (where bpy is 2,2′-bipyridine, pip-Ac is 1-piperidineacetato and mor-Ac is 4-morpholineacetato) have been synthesized and characterized by elemental analyses, molar conductivity measurements and spectroscopic methods (FT-IR, 1H NMR, UV–Vis). The complexes have been tested for in vitro cytotoxic activity against human breast cancer cell line, T47D. The binding of these complexes with DNA has been investigated by absorption spectroscopy, fluorescence titration spectra, EB displacement and gel chromatography. The results suggest that the complexes can bind to DNA cooperatively through a static mechanism at low concentrations (~0.57 μM). The thermodynamic parameters indicated that the van der Waals and hydrogen binding might play a major role in the interaction of these complexes with DNA.


DNA-binding Pd(II) complex 1-piperidineacetate 4-morpholinoacetate Cytotoxicity 

Copyright information

© Iranian Chemical Society 2013

Authors and Affiliations

  • Maryam Saeidifar
    • 1
  • Hassan Mansouri-Torshizi
    • 2
  • Adele Divsalar
    • 3
  • Ali Akbar Saboury
    • 4
  1. 1.Nanotechnology and Advanced Materials DepartmentMaterials and Energy Research CenterKarajIran
  2. 2.Department of ChemistryUniversity of Sistan and BaluchestanZahedanIran
  3. 3.Department of Biological SciencesTarbiat Moallem UniversityTehranIran
  4. 4.Institute of Biochemistry and BiophysicsUniversity of TehranTehranIran

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