CEN Case Reports

, Volume 8, Issue 1, pp 67–70 | Cite as

Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms

  • Weijie Violet Lin
  • Christie Gloria TurinEmail author
  • David Walter McCormick
  • Christopher Haas
  • Gregory Constantine
Case Report


Oxalate nephropathy is associated with hereditary hyperoxaluria, Crohn disease, and previous gastric or intestinal surgery, especially in the setting of increased oxalate intake or ethylene glycol ingestion. We present a patient whose intake of vitamin C supplements (2 g/day), exacerbated by predisposing factors of prior small bowel obstruction and resection, and benign prostate hyperplasia (BPH), resulted in acute kidney injury due to oxalate nephropathy. We review past reports of vitamin C-induced oxalate nephropathy and discuss the underlying precipitating factors.


Acute renal failure Dialysis Vitamin C 



The authors are grateful to Bhuvaneswari Krishnan MD for pathology interpretation and Divya Janardhanan MD and Saed Shawar MD for their assistance in the medical care of this patient.

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflicts of interest exists.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

The subject’s identity has been masked. No identifying details are included in this manuscript to ensure complete anonymity.


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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • Weijie Violet Lin
    • 1
  • Christie Gloria Turin
    • 2
    Email author
  • David Walter McCormick
    • 2
  • Christopher Haas
    • 2
  • Gregory Constantine
    • 2
  1. 1.School of MedicineBaylor College of MedicineHoustonUSA
  2. 2.Department of MedicineBaylor College of MedicineHoustonUSA

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