Membranous glomerulonephritis with an LMNA mutation
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We had encountered the case of membranous glomerulonephritis (MGN) with dilated cardiomyopathy due to LMNA gene mutation. LMNA mutation was known as a cause of ‘laminopathy’ such as dilated cardiomyopathy, muscular dystrophy, neuropathy and so on. LMNA gene might be a candidate of genetic basis in cryptogenic MGN.
KeywordsMembranous glomerulonephritis Dilated cardiomyopathy Lamin A/C LMNA
We would like to thank Dr. Kazuaki Kaitani and Dr. Naoaki Onishi, department of cardiology, Japanese Red Cross Otsu Hospital, Japan, for their great contribution. Furthermore, we thank Dr. Yoichiro Kobashi and Mr. Shiomi Yoshida, Tenri Institute of Medical Research, Japan for their help with the histological analyses.
Compliance with ethical standards
Conflict of interest
All the authors have declared that no conflict of interest exists.
Human and animal rights
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent was obtained from the patient for being included in the study.