Iranian Polymer Journal

, Volume 21, Issue 12, pp 829–836 | Cite as

A superabsorbent hydrogel network based on poly((2-dimethylaminoethyl) methacrylate) and sodium alginate obtained by γ-radiation: synthesis and characterization

  • Ghasem R. Bardajee
  • Zari Hooshyar
  • Fatemeh Zehtabi
  • Ali Pourjavadi
Original Paper


In this study, the synthesis and characterization of a novel nano-porous superabsorbent hydrogel with high water swelling capacity is described. A nano-porous hydrogel was prepared by employing (2-dimethylaminoethyl) methacrylate (PDMAEMA) as a pH sensitive monomer and sodium alginate (SA) as a water soluble polysaccharide under γ-ray irradiation. The polymerization reaction was performed at room temperature in the absence of chemically toxic crosslinking agent and initiators. The interactive parameters including biopolymer backbone concentration, monomer concentration and γ-irradiation dose were selected as major factors in the synthesis of superabsorbent and three levels for each factor were applied to obtain the highest water swelling according to the central composite design (CCD) method. According to the results of nine different tests which were derived by CCD method, the optimum conditions were determined. The results showed that the hydrogel prepared at concentration of 1.5 g SA, 2.1 mol/L PDMAEMA and at a radiation dose of 5 kGy displayed the highest swelling capacity. In continuation, the effect of salt, pH, and particle size on the swelling behavior of the obtained samples was investigated. We found that the swelling of the optimized sample first increased and then dropped with increases in pH from 2 to 12 and the maximum water absorbency was observed at pH 7. Finally, different techniques such as Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscope (SEM) were applied for the characterization of optimized nano-porous hydrogel.


(2-Dimethylaminoethyl) methacrylate Sodium alginate γ-Irradiation Superabsorbent hydrogel 


  1. 1.
    Alcantara MTS, Brant AJC, Giannini DR, Pessoa JOCP, Andrade AB, Riella HG, Lugao AB (2012) Influence of dissolution processing of PVA blends on the characteristics of their hydrogels synthesized by radiation. Part I: gel fraction, swelling, and mechanical properties. Radiat Phys Chem 81:1465–1470CrossRefGoogle Scholar
  2. 2.
    Zhou C, Li P, Qi X, Sharif ARM, Poon YF, Cao Y, Chang MW, Leong SSJ, Chan-Park MB (2011) A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine. Biomaterials 32:2704–2712CrossRefGoogle Scholar
  3. 3.
    Jha PK, Jha R, Gupta BL, Guha SK (2010) Effect of γ-dose rate and total dose interrelation on the polymeric hydrogel: a novel injectable male contraceptive. Radiat Phys Chem 79:663–671CrossRefGoogle Scholar
  4. 4.
    Turturro SB, Guthrie MJ, Appel AA, Drapala PW, Brey EM, Pérez-Luna VH, Mieler WF, Kang-Mieler JJ (2011) The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function. Biomaterials 32:3620–3626CrossRefGoogle Scholar
  5. 5.
    Raafat AI, Araby E, Lotfy S (2012) Enhancement of fibrinolytic enzyme production from Bacillus subtilis via immobilization process onto radiation synthesized starch/dimethylaminoethyl methacrylate hydrogel. Carbohydr Polym 87:1369–1374CrossRefGoogle Scholar
  6. 6.
    Zuidema JM, Pap MM, Jaroch DB, Morrison FA, Gilbert RJ (2011) Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair. Acta Biomater 7:1634–1643CrossRefGoogle Scholar
  7. 7.
    Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, Han Y, Zhai M, Wei S (2010) A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydr Polym 82:1297–1305CrossRefGoogle Scholar
  8. 8.
    LoPresti C, Vetri V, Ricca M, Foderà V, Tripodo G, Spadaro G, Dispenza C (2011) Pulsatile protein release and protection using radiation-crosslinked polypeptide hydrogel delivery devices. React Funct Polym 71:155–167CrossRefGoogle Scholar
  9. 9.
    Nizam El-Din HM, AbdAlla SG, El-Naggar AWM (2010) Swelling and drug release properties of acrylamide/carboxymethyl cellulose networks formed by gamma irradiation. Radiat Phys Chem 79:725–730CrossRefGoogle Scholar
  10. 10.
    Khodja AN, Mahlous M, Tahtat D, Benamer S, Youcef SL, Chader H, Mouhoub L, Sedgelmaci M, Ammi N, Mansouri MB, Mameri S (2012) Evaluation of healing activity of PVA/chitosan hydrogels on deep second degree burn: pharmacological and toxicological tests. Burns (in press)Google Scholar
  11. 11.
    Ramseyer P, Micol LA, Engelhardt E, Osterheld M, Hubbell JA, Frey P (2010) In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence. Biomaterials 31:4613–4619CrossRefGoogle Scholar
  12. 12.
    Soler DM, Rodríguez Y, Correa H, Moreno A, Carrizales L (2012) Pilot scale-up and shelf stability of hydrogel wound dressings obtained by gamma radiation. Radiat Phys Chem 81:1249–1253CrossRefGoogle Scholar
  13. 13.
    Park J, Kim H, Choi J, Gwon H, Shin Y, Lim Y, Khil MS, Nho Y (2012) Effects of annealing and the addition of PEG on the PVA based hydrogel by gamma ray. Radiat Phys Chem 81:857–860CrossRefGoogle Scholar
  14. 14.
    Oliveira MJA, Parra DF, Amato VS, Lugão AB (2012) Hydrogel membranes of PVAI/clay by gamma radiation. Radiat Phys Chem (in press)Google Scholar
  15. 15.
    Bardajee GR, Pourjavadi A, Sheikh N, Amini-Fazl MS (2008) Grafting of acrylamide onto kappa-carrageenan via gamma-irradiation: optimization and swelling behavior. Radiat Phys Chem 77:131–137CrossRefGoogle Scholar
  16. 16.
    Pourjavadi A, Barzegar S, Zeidabadi F (2007) Synthesis and properties of biodegradable hydrogels of kappa-carrageenan grafted acrylic acid-co-2-acrylamido-2-methylpropanesulfonic acid as candidates for drug delivery systems. React Funct Polym 67:644–654CrossRefGoogle Scholar
  17. 17.
    Choi J, Kim J, Srinivasan P, Kim J, Park H, Byun M, Lee J (2009) Comparison of gamma ray and electron beam irradiation on extraction yield, morphological and antioxidant properties of polysaccharides from tamarind seed. Radiat Phys Chem 78:605–609CrossRefGoogle Scholar
  18. 18.
    Sokker HH, El-Sawy NM, Hassan MA, El-Anadouli BE (2011) Adsorption of crude oil from aqueous solution by hydrogel of chitosan based polyacrylamide prepared by radiation induced graft polymerization. J Hazard Mater 190:359–365CrossRefGoogle Scholar
  19. 19.
    Jipa IM, Stroescu M, Stoica-Guzun A, Dobre T, Jinga S, Zaharescu T (2012) Effect of gamma irradiation on biopolymer composite films of poly(vinyl alcohol) and bacterial cellulose. Nucl Inst Method Phys Res Sect B 278:82–87CrossRefGoogle Scholar
  20. 20.
    Wang D, Hill DJT, Rasoul F, Whittaker AK (2011) A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels. Radiat Phys Chem 80:207–212CrossRefGoogle Scholar
  21. 21.
    Tan R, She Z, Wang M, Fang Z, Liu Y, Feng Q (2012) Thermo-sensitive alginate-based injectable hydrogel for tissue engineering. Carbohydr Polym 87:1515–1521CrossRefGoogle Scholar
  22. 22.
    Wang Q, Xie X, Zhang X, Zhang J, Wang A (2010) Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly(acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release. Int J Biol Macromol 46:356–362CrossRefGoogle Scholar
  23. 23.
    Hunt NC, Smith AM, Gbureck U, Shelton RM, Grover LM (2010) Encapsulation of fibroblasts causes accelerated alginate hydrogel degradation. Acta Biomater 6:3649–3656CrossRefGoogle Scholar
  24. 24.
    Liu Y, Yang L, Li J, Shi Z (2005) Grafting of methyl methacrylate onto sodium alginate initiated by potassium ditelluratoargentate (III). J Appl Polym Sci 97:1688–1694CrossRefGoogle Scholar
  25. 25.
    Zha L, Hu J, Wang C, Hu S, Elaissari A, Zhang Y (2002) Preparation and characterization of poly(N-isopropylacrylamide-co-dimethylaminoethyl methacrylate) microgel latexes. Colloid Polym Sci 280:1–6CrossRefGoogle Scholar
  26. 26.
    Traitel T, Cohen Y, Kost J (2000) Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials 21:1679–1687CrossRefGoogle Scholar
  27. 27.
    Basan H, Gümüsderelíoglu M, Orbey T (2002) Diclofenac sodium releasing pH-sensitive monolithic devices. Int J Pharm 245:191–198CrossRefGoogle Scholar
  28. 28.
    Vande-Wetering P, Schuurmans-Nieuwenbroek NME, Van Steenbergen MJ, Crommelin DJA, Hennink WE (2000) Copolymers of 2-(dimethylamino) ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents. J Control Release 64:193–203CrossRefGoogle Scholar
  29. 29.
    Kurisawa M, Yokoyama M, Okano T (2000) Gene expression control by temperature with thermo-responsive polymeric gene carriers. J Control Release 69:127–137CrossRefGoogle Scholar
  30. 30.
    Uzun C, Hassnisaber M, Sen M, Guven O (2003) Enhancement and control of cross-linking of dimethylaminoethyl methacrylate irradiated at low dose rate in the presence of ethylene glycol dimethacrylate. Nucl Inst Method Phys Res Sect B 208:242–246CrossRefGoogle Scholar
  31. 31.
    Sen M, Sarı M (2005) Radiation synthesis and characterization of poly(N, N-dimethylaminoethyl methacrylate-co-N-vinyl2-pyrrolidone) hydrogels. Eur Polym J 41:1304–1314CrossRefGoogle Scholar

Copyright information

© Iran Polymer and Petrochemical Institute 2012

Authors and Affiliations

  • Ghasem R. Bardajee
    • 1
  • Zari Hooshyar
    • 1
  • Fatemeh Zehtabi
    • 1
  • Ali Pourjavadi
    • 2
  1. 1.Department of ChemistryPayame Noor UniversityTehranIran
  2. 2.Polymer Research Laboratory, Department of ChemistrySharif University of TechnologyTehranIran

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