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A case of pulmonary artery intimal sarcoma successfully treated using concurrent chemoradiotherapy and subsequent chemotherapy

  • Terumi AsoEmail author
  • Masako Terao
  • Hisashi Endo
  • Masahiro Tabata
Case report
First Online:
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Abstract

Pulmonary artery intimal sarcoma (PAIS) is a rare malignancy with an extremely poor prognosis. A 43-year-old man visited our hospital with shortness of breath and suddenly experienced cardiopulmonary arrest before he could be examined. After prompt resuscitation, we diagnosed PAIS, but the patient refused to undergo surgery because of the high perioperative mortality risk. Thus, the patient was treated using concurrent chemoradiotherapy with weekly paclitaxel therapy, as well as subsequent chemotherapy. The patient continued chemotherapy for 36 months until he elected to discontinue treatment. To the best of our knowledge, this is the first case of PAIS, which is difficult to resect, that was successfully treated using concurrent chemoradiotherapy and subsequent chemotherapy.

Keywords

Pulmonary artery Intimal sarcoma Chemoradiotherapy 
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Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving Human Participants

For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Mandelstamm M (1923) Uber primare Neubildungen des Herzens. Virchows Arch Pathol Anat 245:43–45CrossRefGoogle Scholar
  2. 2.
    Bandyopadhyay D, Panchabhai TS, Bajaj NS et al (2016) Primary pulmonary artery sarcoma: a close associate of pulmonary embolism- 20-year observational analysis. J Thorac Dis 8:2592–2601CrossRefGoogle Scholar
  3. 3.
    Wong HH, Gounaris I, McCormack A et al (2015) Presentation and management of pulmonary artery sarcoma. Clin Waarcoma Res 5:3CrossRefGoogle Scholar
  4. 4.
    Mussot S, Ghigna MR, Mercier O et al (2013) Retrospective institutional study of 31 patients treated for pulmonary artery sarcoma. Eur J Cardiothorac Surg 43:787–793CrossRefGoogle Scholar
  5. 5.
    Parish JM, Rosenow EC 3rd, Swensen SJ et al (1996) Pulmonary artery sarcoma. Clinical features. Chest 110:1480–1488CrossRefGoogle Scholar
  6. 6.
    Kurger I, Borowski A, Horst M et al (1990) Symptoms, diagnosis, and therapy of primary sarcoma of the pulmonary artery. Thorac Cardiovasc Surg 38:91–95CrossRefGoogle Scholar
  7. 7.
    Travis WD, Brambilla E, Burke AP et al (2015) WHO classification of tumours of lung, pleura, thymus & heart. 4th edn. IARC Press, Lyon, pp 28–129Google Scholar
  8. 8.
    Jiang S, Li J, Zeng Q, Liang J (2017) Pulmonary artery intimal sarcoma misdiagnosed as pulmonary embolism: a case report. Oncol Lett 13:2713–2716CrossRefGoogle Scholar
  9. 9.
    Lee Y, Kim HJ, Yoon H et al (2016) Clinical characteristics and treatment outcomes of primary pulmonary artery sarcoma in Korea. J Korean Med Sci 31:1755–1760CrossRefGoogle Scholar
  10. 10.
    Ote EL, Oriuchi N, Miyashita G et al (2011) Pulmonary artery intimal sarcoma: the role of 18F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment. Jpn J Radiol 29:279–282CrossRefGoogle Scholar
  11. 11.
    Yeung DF, Johnston A, Simmons C et al (2018) Multimodality imaging of a pulmonary artery sarcoma. Echocardiography 35:123–125CrossRefGoogle Scholar
  12. 12.
    Hmelik S, Dobrenic M, Huic D (2018) F-18 FDG PET/CT in pulmonary artery sarcoma: clinical vignette. Nucl Med Rev Cent East Eur 21:48–49CrossRefGoogle Scholar
  13. 13.
    Blackman SH, Rice DC, Correa AM et al (2009) Management of primary pulmonary artery sarcomas. Ann Thorac Surg 87:977–984CrossRefGoogle Scholar
  14. 14.
    Yin K, Zhanu Z, Luo R et al (2018) Clinical features and surgical outcomes of pulmonary artery sarcoma. J Thorac Cardiovasc Surg 155:1109–1115CrossRefGoogle Scholar
  15. 15.
    Penel N, Bui BN, Bay JO et al (2008) Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX study. J Clin Oncol 26:5269–5274CrossRefGoogle Scholar
  16. 16.
    National Comprehensive Cancer Network (2018) National Comprehensive Cancer Network Guidelines: Soft tissue sarcoma version 1.2018. https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf. Accessed Mar 2018
  17. 17.
    Fujisawa Y, Yoshino K, Kadono T et al (2014) Chemoradiotherapy with taxane is superior to conventional surgery and radiotherapy in the management of cutaneous angiosarcoma: a multicentre, retrospective study. Br J Dermatol 171:1493–1500CrossRefGoogle Scholar

Copyright information

© The Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of Clinical OncologyFukuyama City HospitalHiroshimaJapan
  2. 2.Center for Clinical OncologyOkayama University HospitalOkayamaJapan

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