Skip to main content

Advertisement

Log in

A case report of primary malignant melanoma of male urethra with distinct appearance in multiple regions

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

A 66-year-old man presented with macrohematuria. Cystoscope examination found a 5 mm nodular tumor at external urethral orifice and multiple papillary tumors at fossa navicularis of urethra; those are non-black colored. Transurethral resection of the urethra tumor was performed, and pathologically diagnosed as malignant melanoma. Image examinations showed no lymphadenopathy and metastasis. Accordingly, total penectomy was conducted to remove the remaining tumors, resulting in surgically curative resection. After the operation, monthly interferon-β injection into inguinal region has been administered as adjuvant therapy, resulting in no recurrence at 6 months after penectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Stillwell TJ, Zincke H, Gaffey TA et al (1988) Mallignant melanoma of the penis. J Urol 140:72–75

    CAS  PubMed  Google Scholar 

  2. El-Safadi S, Estel R, Mayser P et al (2014) Primary malignant melanoma of the urethra: a systemic analysis of the current literature. Arch Gynecol Obset 289:935–943

    Article  Google Scholar 

  3. Batsakis JG, Suarez P (2000) Mucosal melanomas: a review. Adv Anat Pathol 7:785–796

    Google Scholar 

  4. Papeš D, Altarac S, Arslani N et al (2014) Melanoma of the glans penis and urethra. Urology 83:6–11

    Article  PubMed  Google Scholar 

  5. van Geel AN, den Bakker MA, Kirkels W et al (2007) Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature. Urology 70:143–147

    Article  PubMed  Google Scholar 

  6. De Giorgi V, Grazzini M, Massi D et al (2010) Melanoma of the penis: a clinical dermoscopic case study. Acta Derm Venereol 90:87–88

    Article  PubMed  Google Scholar 

  7. Lebacle C, Pignot G, Mateus C et al (2012) Metastatic melanoma in upper urinary tract: three cases and literature review. Prog Urol 22:736–739

    Article  CAS  PubMed  Google Scholar 

  8. Venyo AK (2014) Melanoma of the urinary bladder: a review of the literature. Surg Res Pract 2014:605802

    PubMed  PubMed Central  Google Scholar 

  9. Wong JA, Bell DG (2006) Primary malignant melanoma of the prostate: case report and review of the literature. Can J Urol 13:3053–3056

    PubMed  Google Scholar 

  10. Carroll PR, Dixon CM (1992) Surgical anatomy of the male and female urethra. Urol Clin North Am 19:339–346

    CAS  PubMed  Google Scholar 

  11. Irisawa C, Onmura Y, Matsushita S (1987) Metastatic malignant melanoma of the urinary bladder: a case report. Hinyokika Kiyo 33:424–427

    CAS  PubMed  Google Scholar 

  12. Watanabe T, Kura N, Yamada T et al (1991) A case of malignant melanoma of the penis. Hinyokika Kiyo 37:637–639

    CAS  PubMed  Google Scholar 

  13. Watanabe J, Yamamoto S, Souma T et al (2000) Primary malignant melanoma of the male urethra. Int J Urol 7:351–353

    Article  CAS  PubMed  Google Scholar 

  14. Bracken RB, Diokno AC (1974) Melanoma of the penis and urethra: 2 case reports and review of the literature. J Urol 111:198–200

    CAS  PubMed  Google Scholar 

  15. Levine RL (1980) Urethral cancer. Cancer 45:1965–1972

    CAS  PubMed  Google Scholar 

  16. Hankins CL, Weston P (2006) Re: melanoma of the penis, scrotum and male urethra: a 40-year single institution experience. R. Sánchez-Ortiz, S. F. Huang, P. Tamboli, V. C. Prieto, G. Hester and C. A. Pettaway. J Urol 175:1574–1575

    Article  PubMed  Google Scholar 

  17. Kirkwood JM, Ibrahim JG, Sondak VK et al (2000) High-and low-dose interferon alfa-2b in high-risk melanoma: first analysis of inter-group trial E1690/S9111/C9190. J Clin Oncol 18:2444–2450

    CAS  PubMed  Google Scholar 

  18. Flaherty KT, Infante JR, Daud A et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367:1694–1703

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Di Giacomo AM, Ascierto PA, Pilla L et al (2012) Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial. Lancet Oncol 13:879–886

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masaki Shiota.

Ethics declarations

Conflicts of interest

All authors declare no potential conflict of interest to disclose.

Research involving Human Participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the individual included in the study.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takamatsu, D., Shiota, M., Sugimoto, M. et al. A case report of primary malignant melanoma of male urethra with distinct appearance in multiple regions. Int Canc Conf J 5, 174–177 (2016). https://doi.org/10.1007/s13691-016-0252-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-016-0252-z

Keywords

Navigation