Skip to main content

Advertisement

Log in

A Review of Childhood Behavioral Problems and Disorders in the Development of Obesity: Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Beyond

  • Etiology of Obesity (T Gill, Section Editor)
  • Published:
Current Obesity Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Given the high rates of pediatric and adult obesity, it is imperative to identify early risk factors that might contribute to excess weight gain. This review aims to investigate the relationship between childhood behavioral problems with the development and persistence of obesity. Specifically, this review highlights the association of obesity with (1) neurocognitive constructs, such as executive functioning and inhibition/impulsivity, and (2) disorders commonly diagnosed in childhood, including attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

Recent Findings

Consistent evidence supports a relationship between childhood behavioral problems, executive functioning, inhibition/impulsivity, ADHD, and ASD with obesity across the lifespan. Longitudinal studies suggest behavior problems, neurocognitive functioning deficits, and ADHD symptoms in childhood predict weight gain over time.

Summary

Identifying risk factors in childhood that promote obesity may help develop targeted intervention and prevention programs. Additional research should elucidate mechanisms that account for these relationships.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

  1. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014;311(8):806–14. https://doi.org/10.1001/jama.2014.732.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ortega FB, Lavie CJ, Blair SN. Obesity and cardiovascular disease. Circ Res. 2016;118(11):1752–70. https://doi.org/10.1161/CIRCRESAHA.115.306883.

    Article  CAS  PubMed  Google Scholar 

  3. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci. 2012;1271(1):37–43. https://doi.org/10.1111/j.1749-6632.2012.06750.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220–9. https://doi.org/10.1001/archgenpsychiatry.2010.2.

    Article  PubMed  Google Scholar 

  5. Griffiths LJ, Parsons TJ, Hill AJ. Self-esteem and quality of life in obese children and adolescents: a systematic review. Int J Pediatr Obes. 2010;5(4):282–304. https://doi.org/10.3109/17477160903473697.

    Article  PubMed  Google Scholar 

  6. Ul-Haq Z, Mackay DF, Fenwick E, Pell JP. Meta-analysis of the association between body mass index and health-related quality of life among adults, assessed by the SF-36. Obesity (Silver Spring). 2013;21(3):E322–7. https://doi.org/10.1002/oby.20107.

    Article  Google Scholar 

  7. Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309(1):71–82. https://doi.org/10.1001/jama.2012.113905.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352(11):1138–45. https://doi.org/10.1056/NEJMsr043743.

    Article  CAS  PubMed  Google Scholar 

  9. Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes. 2011;35(7):891–8. https://doi.org/10.1038/ijo.2010.222.

    Article  CAS  Google Scholar 

  10. Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17(2):95–107. https://doi.org/10.1111/obr.12334.

    Article  CAS  PubMed  Google Scholar 

  11. de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res. 2010;178(2):230–5. https://doi.org/10.1016/j.psychres.2009.04.015.

    Article  PubMed  Google Scholar 

  12. Preiss K, Brennan L, Clarke D. A systematic review of variables associated with the relationship between obesity and depression. Obes Rev. 2013;14(11):906–18. https://doi.org/10.1111/obr.12052.

    Article  CAS  PubMed  Google Scholar 

  13. Anderson SE, Cohen P, Naumova EN, Must A. Relationship of childhood behavior disorders to weight gain from childhood into adulthood. Ambul Pediatr. 2006;6(5):297–301. https://doi.org/10.1016/j.ambp.2006.06.002.

    Article  PubMed  Google Scholar 

  14. Anderson SE, He X, Schoppe-Sullivan S, Must A. Externalizing behavior in early childhood and body mass index from age 2 to 12 years: longitudinal analyses of a prospective cohort study. BMC Pediatr. 2010;10(1):49. https://doi.org/10.1186/1471-2431-10-49.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Halfon N, Larson K, Slusser W. Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17. Acad Pediatr. 2013;13(1):6–13. https://doi.org/10.1016/j.acap.2012.10.007.

    Article  PubMed  Google Scholar 

  16. Suglia SF, Duarte CS, Chambers EC, Boynton-Jarrett R. Social and behavioral risk factors for obesity in early childhood. J Dev Behav Pediatr. 2013;34(8):549–56. https://doi.org/10.1097/DBP.0b013e3182a509c0.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Lumeng JC, Gannon K, Cabral HJ, Frank DA, Zuckerman B. Association between clinically meaningful behavior problems and overweight in children. Pediatrics. 2003;112(5):1138–45. https://doi.org/10.1542/peds.112.5.1138.

    Article  PubMed  Google Scholar 

  18. White B, Nicholls D, Christie D, Cole TJ, Viner RM. Childhood psychological function and obesity risk across the lifecourse: findings from the 1970 British Cohort Study. Int J Obes. 2012;36(4):511–6. https://doi.org/10.1038/ijo.2011.253.

    Article  CAS  Google Scholar 

  19. Duarte CS, Sourander A, Nikolakaros G, Pihlajamaki H, Helenius H, Piha J, et al. Child mental health problems and obesity in early adulthood. J Pediatr. 2010;156(1):93–7. https://doi.org/10.1016/j.jpeds.2009.06.066.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Datar A, Sturm R. Childhood overweight and parent- and teacher-reported behavior problems: evidence from a prospective study of kindergartners. Arch Pediatr Adolesc Med. 2004;158(8):804–10. https://doi.org/10.1001/archpedi.158.8.804.

    Article  PubMed  Google Scholar 

  21. Datar A, Sturm R. Childhood overweight and elementary school outcomes. Int J Obes. 2006;30(9):1449–60. https://doi.org/10.1038/sj.ijo.0803311.

    Article  CAS  Google Scholar 

  22. von Stumm S, Deary IJ, Kivimaki M, Jokela M, Clark H, Batty GD. Childhood behavior problems and health at midlife: 35-year follow-up of a Scottish birth cohort. J Child Psychol Psychiatry. 2011;52(9):992–1001. https://doi.org/10.1111/j.1469-7610.2011.02373.x.

    Article  Google Scholar 

  23. • Pauli-Pott U, Neidhard J, Heinzel-Gutenbrunner M, Becker K. On the link between attention deficit/hyperactivity disorder and obesity: do comorbid oppositional defiant and conduct disorder matter? Eur Child Adolesc Psychiatry. 2014;23(7):531–7. https://doi.org/10.1007/s00787-013-0489-4. This study sought to tease apart the relationship among oppositional defiant disorder, conduct disorder, and ADHD with obesity in children. Study findings revealed that children with oppositional defiant disorder/conduct disorder had higher body weight than children without oppositional defiant disorder/conduct disorder (regardless of ADHD status). However, this study did not find support for increased body weight for children with ADHD when controlling for oppositional defiant disorder/conduct disorder.

    Article  PubMed  Google Scholar 

  24. Pasch KE, Nelson MC, Lytle LA, Moe SG, Perry CL. Adoption of risk-related factors through early adolescence: associations with weight status and implications for causal mechanisms. J Adolesc Health. 2008;43(4):387–93. https://doi.org/10.1016/j.jadohealth.2008.02.009.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Huang DY, Lanza HI, Wright-Volel K, Anglin MD. Developmental trajectories of childhood obesity and risk behaviors in adolescence. J Adolesc. 2013;36(1):139–48. https://doi.org/10.1016/j.adolescence.2012.10.005.

    Article  PubMed  Google Scholar 

  26. Mamun AA, O’Callaghan MJ, Cramb SM, Najman JM, Williams GM, Bor W. Childhood behavioral problems predict young adults’ BMI and obesity: evidence from a birth cohort study. Obesity (Silver Spring). 2009;17(4):761–6. https://doi.org/10.1038/oby.2008.594.

    Article  Google Scholar 

  27. Eichen DM, Matheson BE, Appleton-Knapp SL, Boutelle KN. Neurocognitive treatments for eating disorders and obesity. Curr Psychiatry Rep. 2017;19(9):62. https://doi.org/10.1007/s11920-017-0813-7.

    Article  PubMed  Google Scholar 

  28. • Hayes JF, Eichen DM, Barch DM, Wilfley DE. Executive function in childhood obesity: promising intervention strategies to optimize treatment outcomes. Appetite. 2017; https://doi.org/10.1016/j.appet.2017.05.040. A recent review examining the role of executive functions in childhood weight-loss treatment with a focus on the role of executive function training in improving success of pediatric obesity interventions.

  29. •• Liang J, Matheson BE, Kaye WH, Boutelle KN. Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int J Obes. 2014;38(4):494–506. https://doi.org/10.1038/ijo.2013.142. This systematic review examines the relationship between obesity and obesity-related behaviors with neurocognitive functioning in children, finding consistent support in the literature for a negative relationship among obesity and executive functioning, attention, visuo-spatial performance, and motor skills. This review reported mixed evidence regarding the relationship between obesity and obesity-related behaviors with cognitive functioning, learning, language, memory, and academic achievement in children and adolescents, and suggested several areas for further research exploration.

    Article  CAS  Google Scholar 

  30. Reinert KR, Po'e EK, Barkin SL. The relationship between executive function and obesity in children and adolescents: a systematic literature review. J Obes. 2013;2013:820956–10. https://doi.org/10.1155/2013/820956.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Holcke M, Marcus C, Gillberg C, Fernell E. Paediatric obesity: a neurodevelopmental perspective. Acta Paediatr. 2008;97(6):819–21. https://doi.org/10.1111/j.1651-2227.2008.00816.x.

    Article  PubMed  Google Scholar 

  32. Bruce AS, Black WR, Bruce JM, Daldalian M, Martin LE, Davis AM. Ability to delay gratification and BMI in preadolescence. Obesity (Silver Spring). 2011;19(5):1101–2. https://doi.org/10.1038/oby.2010.297.

    Article  Google Scholar 

  33. Caleza C, Yanez-Vico RM, Mendoza A, Iglesias-Linares A. Childhood obesity and delayed gratification behavior: a systematic review of experimental studies. J Pediatr 2016;169:201–207 e1. https://doi.org/10.1016/j.jpeds.2015.10.008.

  34. Schlam TR, Wilson NL, Shoda Y, Mischel W, Ayduk O. Preschoolers’ delay of gratification predicts their body mass 30 years later. J Pediatr. 2013;162(1):90–3. https://doi.org/10.1016/j.jpeds.2012.06.049.

    Article  PubMed  Google Scholar 

  35. Spitznagel MB, Alosco M, Galioto R, Strain G, Devlin M, Sysko R, et al. The role of cognitive function in postoperative weight loss outcomes: 36-month follow-up. Obes Surg. 2014;24(7):1078–84. https://doi.org/10.1007/s11695-014-1205-2.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Spitznagel MB, Alosco M, Strain G, Devlin M, Cohen R, Paul R, et al. Cognitive function predicts 24-month weight loss success after bariatric surgery. Surg Obes Relat Dis. 2013;9(5):765–70. https://doi.org/10.1016/j.soard.2013.04.011.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Spitznagel MB, Garcia S, Miller LA, Strain G, Devlin M, Wing R, et al. Cognitive function predicts weight loss after bariatric surgery. Surg Obes Relat Dis. 2013;9(3):453–9. https://doi.org/10.1016/j.soard.2011.10.008.

    Article  PubMed  Google Scholar 

  38. Galioto R, Bond D, Gunstad J, Pera V, Rathier L, Tremont G. Executive functions predict weight loss in a medically supervised weight loss programme. Obes Sci Pract. 2016;2(4):334–40. https://doi.org/10.1002/osp4.70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Verbeken S, Braet C, Goossens L, van der Oord S. Executive function training with game elements for obese children: a novel treatment to enhance self-regulatory abilities for weight-control. Behav Res Ther. 2013;51(6):290–9. https://doi.org/10.1016/j.brat.2013.02.006.

    Article  PubMed  Google Scholar 

  40. • Lavagnino L, Arnone D, Cao B, Soares JC, Selvaraj S. Inhibitory control in obesity and binge eating disorder: a systematic review and meta-analysis of neurocognitive and neuroimaging studies. Neurosci Biobehav Rev. 2016;68:714–26. https://doi.org/10.1016/j.neubiorev.2016.06.041. This systematic review examined 37 studies that measured inhibitory control among participants with obesity, with and without BED, and conducted a meta-analysis specifically on studies that used the stop-signal task to assess for inhibitory control. The relationship between other inhibitory control tasks (delay discounting, go/no-go task, and Stroop task) and obesity were covered in this review as well.

    Article  PubMed  Google Scholar 

  41. Kulendran M, Vlaev I, Sugden C, King D, Ashrafian H, Gately P, et al. Neuropsychological assessment as a predictor of weight loss in obese adolescents. Int J Obes. 2014;38(4):507–12. https://doi.org/10.1038/ijo.2013.198.

    Article  CAS  Google Scholar 

  42. Lawrence NS, O’Sullivan J, Parslow D, Javaid M, Adams RC, Chambers CD, et al. Training response inhibition to food is associated with weight loss and reduced energy intake. Appetite. 2015;95:17–28. https://doi.org/10.1016/j.appet.2015.06.009.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Stice E, Lawrence NS, Kemps E, Veling H. Training motor responses to food: a novel treatment for obesity targeting implicit processes. Clin Psychol Rev. 2016;49:16–27. https://doi.org/10.1016/j.cpr.2016.06.005.

    Article  PubMed  Google Scholar 

  44. Stice E, Yokum S, Veling H, Kemps E, Lawrence NS. Pilot test of a novel food response and attention training treatment for obesity: brain imaging data suggest actions shape valuation. Behav Res Ther. 2017;94:60–70. https://doi.org/10.1016/j.brat.2017.04.007.

    Article  PubMed  Google Scholar 

  45. Lawrence NS, Yokum S, Fuller-Marashi L, Veling HP, Kemps E, Stice E. A novel multicomponent food response training intervention reduces body fat and neural and subjective food reward in obese participants. Appetite. 2016;107:686. https://doi.org/10.1016/j.appet.2016.08.061.

    Article  Google Scholar 

  46. Nederkoorn C, Braet C, Van Eijs Y, Tanghe A, Jansen A. Why obese children cannot resist food: the role of impulsivity. Eat Behav. 2006;7(4):315–22. https://doi.org/10.1016/j.eatbeh.2005.11.005.

    Article  PubMed  Google Scholar 

  47. Nederkoorn C, Jansen E, Mulkens S, Jansen A. Impulsivity predicts treatment outcome in obese children. Behav Res Ther. 2007;45(5):1071–5. https://doi.org/10.1016/j.brat.2006.05.009.

    Article  PubMed  Google Scholar 

  48. Delgado-Rico E, Rio-Valle JS, Gonzalez-Jimenez E, Campoy C, Verdejo-Garcia A. BMI predicts emotion-driven impulsivity and cognitive inflexibility in adolescents with excess weight. Obesity (Silver Spring). 2012;20(8):1604–10. https://doi.org/10.1038/oby.2012.47.

    Article  Google Scholar 

  49. Hartmann AS, Rief W, Hilbert A. Laboratory snack food intake, negative mood, and impulsivity in youth with ADHD symptoms and episodes of loss of control eating. Where is the missing link? Appetite. 2012;58(2):672–8. https://doi.org/10.1016/j.appet.2012.01.006.

    Article  PubMed  Google Scholar 

  50. Verdejo-Garcia A, Perez-Exposito M, Schmidt-Rio-Valle J, Fernandez-Serrano MJ, Cruz F, Perez-Garcia M, et al. Selective alterations within executive functions in adolescents with excess weight. Obesity (Silver Spring). 2010;18(8):1572–8. https://doi.org/10.1038/oby.2009.475.

    Article  Google Scholar 

  51. Thamotharan S, Lange K, Zale EL, Huffhines L, Fields S. The role of impulsivity in pediatric obesity and weight status: a meta-analytic review. Clin Psychol Rev. 2013;33(2):253–62. https://doi.org/10.1016/j.cpr.2012.12.001.

    Article  PubMed  Google Scholar 

  52. Fuemmeler BF, Ostbye T, Yang C, McClernon FJ, Kollins SH. Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study. Int J Obes. 2011;35(6):852–62. https://doi.org/10.1038/ijo.2010.214.

    Article  CAS  Google Scholar 

  53. Gerlach G, Herpertz S, Loeber S. Personality traits and obesity: a systematic review. Obes Rev. 2015;16(1):32–63. https://doi.org/10.1111/obr.12235.

    Article  CAS  PubMed  Google Scholar 

  54. Hofmann J, Ardelt-Gattinger E, Paulmichl K, Weghuber D, Blechert J. Dietary restraint and impulsivity modulate neural responses to food in adolescents with obesity and healthy adolescents. Obesity (Silver Spring). 2015;23(11):2183–9. https://doi.org/10.1002/oby.21254.

    Article  Google Scholar 

  55. van den Akker K, Stewart K, Antoniou EE, Palmberg A, Jansen A. Food cue reactivity, obesity, and impulsivity: are they associated? Curr Addict Rep. 2014;1(4):301–8. https://doi.org/10.1007/s40429-014-0038-3.

    Article  Google Scholar 

  56. Narayanaswami V, Thompson AC, Cassis LA, Bardo MT, Dwoskin LP. Diet-induced obesity: dopamine transporter function, impulsivity and motivation. Int J Obes. 2013;37(8):1095–103. https://doi.org/10.1038/ijo.2012.178.

    Article  CAS  Google Scholar 

  57. Velazquez-Sanchez C, Ferragud A, Moore CF, Everitt BJ, Sabino V, Cottone P. High trait impulsivity predicts food addiction-like behavior in the rat. Neuropsychopharmacology. 2014;39(10):2463–72. https://doi.org/10.1038/npp.2014.98.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Meule A, Platte P. Facets of impulsivity interactively predict body fat and binge eating in young women. Appetite. 2015;87:352–7. https://doi.org/10.1016/j.appet.2015.01.003.

    Article  PubMed  Google Scholar 

  59. • Giel KE, Teufel M, Junne F, Zipfel S, Schag K. Food-related impulsivity in obesity and Binge Eating Disorder—a systematic update of the evidence. Nutrients. 2017;9(11) https://doi.org/10.3390/nu9111170. This recent article systematically reviewed studies published since 2012 to provide an update on the current status of the literature investigating the link between food-related impulsivity and obesity in individuals with and without BED.

  60. Schag K, Schonleber J, Teufel M, Zipfel S, Giel KE. Food-related impulsivity in obesity and binge eating disorder—a systematic review. Obes Rev. 2013;14(6):477–95. https://doi.org/10.1111/obr.12017.

    Article  CAS  PubMed  Google Scholar 

  61. • Houben K, Nederkoorn C, Jansen A. Eating on impulse: the relation between overweight and food-specific inhibitory control. Obesity (Silver Spring). 2014;22(5):E6–8. An experimental study with adult females that found a significant negative relationship between inhibitory control, as measured by the stop-signal task, and BMI for food-specific stimuli only. https://doi.org/10.1002/oby.20670.

    Article  Google Scholar 

  62. Nederkoorn C, Coelho JS, Guerrieri R, Houben K, Jansen A. Specificity of the failure to inhibit responses in overweight children. Appetite. 2012;59(2):409–13. https://doi.org/10.1016/j.appet.2012.05.028.

    Article  PubMed  Google Scholar 

  63. Cortese S, Faraone SV, Bernardi S, Wang S, Blanco C. Adult attention-deficit hyperactivity disorder and obesity: epidemiological study. Br J Psychiatry. 2013;203(1):24–34. https://doi.org/10.1192/bjp.bp.112.123299.

    Article  PubMed  PubMed Central  Google Scholar 

  64. •• Cortese S, Moreira-Maia CR, St Fleur D, Morcillo-Penalver C, Rohde LA, Faraone SV. Association between ADHD and obesity: a systematic review and meta-analysis. Am J Psychiatry. 2016;173(1):34–43. https://doi.org/10.1176/appi.ajp.2015.15020266. This systematic review investigating the relationship between ADHD and obesity reviewed 42 studies and found support for increased prevelance of obesity in both children and adults with ADHD. Moreover, this meta-analysis revealed significant associations between ADHD and obesity when studies were limited based on design characteristics, such as diagnostic methodology (i.e., ADHD diagnosed with clinical interview; direct anthropometric measurements) and adjusting for confounding variables.

    Article  PubMed  Google Scholar 

  65. Fliers EA, Buitelaar JK, Maras A, Bul K, Hohle E, Faraone SV, et al. ADHD is a risk factor for overweight and obesity in children. J Dev Behav Pediatr. 2013;34(8):566–74. https://doi.org/10.1097/DBP.0b013e3182a50a67.

    Article  PubMed  Google Scholar 

  66. •• Khalife N, Kantomaa M, Glover V, Tammelin T, Laitinen J, Ebeling H, et al. Childhood attention-deficit/hyperactivity disorder symptoms are risk factors for obesity and physical inactivity in adolescence. J Am Acad Child Adolesc Psychiatry. 2014;53(4):425–36. https://doi.org/10.1016/j.jaac.2014.01.009. This longitudinal study revealed that ADHD symptoms, such as inattention and hyperactivity, in childhood predicted obesity in adolescence, providing evidence for directionality of the relationship between ADHD and weight gain over time.

    Article  PubMed  Google Scholar 

  67. Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U. Examining the relationship between attention-deficit/hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry. 2012;21(1):39–49. https://doi.org/10.1007/s00787-011-0230-0.

    Article  PubMed  Google Scholar 

  68. Cook BG, Li D, Heinrich KM. Obesity, physical activity, and sedentary behavior of youth with learning disabilities and ADHD. J Learn Disabil. 2015;48(6):563–76. https://doi.org/10.1177/0022219413518582.

    Article  PubMed  Google Scholar 

  69. Albayrak O, Putter C, Volckmar AL, Cichon S, Hoffmann P, Nothen MM, et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2013;162B(4):295–305. https://doi.org/10.1002/ajmg.b.32144.

    Article  PubMed  Google Scholar 

  70. Shinawi M, Sahoo T, Maranda B, Skinner SA, Skinner C, Chinault C, et al. 11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity. Am J Med Genet A. 2011;155A(6):1272–80. https://doi.org/10.1002/ajmg.a.33878.

    Article  PubMed  Google Scholar 

  71. Cortese S, Holtmann M, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry. 2013;54(3):227–46. https://doi.org/10.1111/jcpp.12036.

    Article  PubMed  Google Scholar 

  72. Schwartz BS, Bailey-Davis L, Bandeen-Roche K, Pollak J, Hirsch AG, Nau C, et al. Attention deficit disorder, stimulant use, and childhood body mass index trajectory. Pediatrics. 2014;133(4):668–76. https://doi.org/10.1542/peds.2013-3427.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Cortese S, Vincenzi B. Obesity and ADHD: clinical and neurobiological implications. Curr Top Behav Neurosci. 2012;9:199–218. https://doi.org/10.1007/7854_2011_154.

    Article  PubMed  Google Scholar 

  74. • Seymour KE, Reinblatt SP, Benson L, Carnell S. Overlapping neurobehavioral circuits in ADHD, obesity, and binge eating: evidence from neuroimaging research. CNS Spectr. 2015;20(4):401–11. https://doi.org/10.1017/S1092852915000383. A targeted reivew of the neuroimaging literature investigating the shared neurocircuitry among ADHD, obesity, and binge eating with a focus on reward processing, response inhibition, and emotional processing and regulation.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Cortese S, Maffeis C, Konofal E, Lecendreux M, Comencini E, Angriman M, et al. Parent reports of sleep/alertness problems and ADHD symptoms in a sample of obese adolescents. J Psychosom Res. 2007;63(6):587–90. https://doi.org/10.1016/j.jpsychores.2007.08.005.

    Article  PubMed  Google Scholar 

  76. Muller A, Claes L, Wilderjans TF, de Zwaan M. Temperament subtypes in treatment seeking obese individuals: a latent profile analysis. Eur Eat Disord Rev. 2014;22(4):260–6. https://doi.org/10.1002/erv.2294.

    Article  PubMed  Google Scholar 

  77. Davis C, Patte K, Levitan RD, Carter J, Kaplan AS, Zai C, et al. A psycho-genetic study of associations between the symptoms of binge eating disorder and those of attention deficit (hyperactivity) disorder. J Psychiatr Res. 2009;43(7):687–96. https://doi.org/10.1016/j.jpsychires.2008.10.010.

    Article  PubMed  Google Scholar 

  78. Docet MF, Larranaga A, Perez Mendez LF, Garcia-Mayor RV. Attention deficit hyperactivity disorder increases the risk of having abnormal eating behaviours in obese adults. Eat Weight Disord. 2012;17(2):e132–6. https://doi.org/10.1007/BF03325337.

    Article  CAS  PubMed  Google Scholar 

  79. Fernandez-Aranda F, Aguera Z, Castro R, Jimenez-Murcia S, Ramos-Quiroga JA, Bosch R, et al. ADHD symptomatology in eating disorders: a secondary psychopathological measure of severity? BMC Psychiatry. 2013;13(1):166. https://doi.org/10.1186/1471-244X-13-166.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Kaisari P, Dourish CT, Higgs S. Attention Deficit Hyperactivity Disorder (ADHD) and disordered eating behaviour: a systematic review and a framework for future research. Clin Psychol Rev. 2017;53:109–21. https://doi.org/10.1016/j.cpr.2017.03.002.

    Article  PubMed  Google Scholar 

  81. Nazar BP, de Sousa Pinna CM, Suwwan R, Duchesne M, Freitas SR, Sergeant J, et al. ADHD rate in obese women with binge eating and bulimic behaviors from a weight-loss clinic. J Atten Disord. 2016;20(7):610–6. https://doi.org/10.1177/1087054712455503.

    Article  PubMed  Google Scholar 

  82. Nazar BP, Suwwan R, de Sousa Pinna CM, Duchesne M, Freitas SR, Sergeant J, et al. Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. Compr Psychiatry. 2014;55(3):572–8. https://doi.org/10.1016/j.comppsych.2013.09.015.

    Article  PubMed  Google Scholar 

  83. Steadman KM, Knouse LE. Is the relationship between ADHD symptoms and binge eating mediated by impulsivity? J Atten Disord. 2016;20(11):907–12. https://doi.org/10.1177/1087054714530779.

    Article  PubMed  Google Scholar 

  84. Citrome L. Lisdexamfetamine for binge eating disorder in adults: a systematic review of the efficacy and safety profile for this newly approved indication—what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract. 2015;69(4):410–21. https://doi.org/10.1111/ijcp.12639.

    Article  CAS  PubMed  Google Scholar 

  85. McElroy SL, Hudson J, Ferreira-Cornwell MC, Radewonuk J, Whitaker T, Gasior M. Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: results of two pivotal phase 3 randomized controlled trials. Neuropsychopharmacology. 2016;41(5):1251–60. https://doi.org/10.1038/npp.2015.275.

    Article  CAS  PubMed  Google Scholar 

  86. McElroy SL, Hudson JI, Mitchell JE, Wilfley D, Ferreira-Cornwell MC, Gao J, et al. Efficacy and safety of lisdexamfetamine for treatment of adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiat. 2015;72(3):235–46. https://doi.org/10.1001/jamapsychiatry.2014.2162.

    Article  Google Scholar 

  87. • Patte KA, Davis CA, Levitan RD, Kaplan AS, Carter-Major J, Kennedy JL. A behavioral genetic model of the mechanisms underlying the link between obesity and symptoms of ADHD. J Atten Disord. 2016:108705471561879. https://doi.org/10.1177/1087054715618793. This study found support for the mediating role of overeating behaviors, as well as elevated dopamine in the ventral striatum, in exploring the relationship between ADHD and obesity.

  88. • Reinblatt SP, Leoutsakos JM, Mahone EM, Forrester S, Wilcox HC, Riddle MA. Association between binge eating and attention-deficit/hyperactivity disorder in two pediatric community mental health clinics. Int J Eat Disord. 2015;48(5):505–11. https://doi.org/10.1002/eat.22342. This cross-sectional study found that binge eating behaviors mediated the relationship between ADHD and obesity in a pediatric sample.

    Article  PubMed  Google Scholar 

  89. Matheson BE, Douglas JM. Overweight and obesity in children with autism spectrum disorder (ASD): a critical review investigating the etiology, development, and maintenance of this relationship. Rev J Autism Dev Disord. 2017;2(4):142–56.

    Article  Google Scholar 

  90. Macdonald M, Esposito P, Ulrich D. The physical activity patterns of children with autism. BMC Res Notes. 2011;4(1):422. https://doi.org/10.1186/1756-0500-4-422.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Mazurek MO, Shattuck PT, Wagner M, Cooper BP. Prevalence and correlates of screen-based media use among youths with autism spectrum disorders. J Autism Dev Disord. 2012;42(8):1757–67. https://doi.org/10.1007/s10803-011-1413-8.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Bandini LG, Anderson SE, Curtin C, Cermak S, Evans EW, Scampini R, et al. Food selectivity in children with autism spectrum disorders and typically developing children. J Pediatr. 2010;157(2):259–64. https://doi.org/10.1016/j.jpeds.2010.02.013.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Evans EW, Must A, Anderson SE, Curtin C, Scampini R, Maslin M, et al. Dietary patterns and body mass index in children with autism and typically developing children. Res Autism Spectr Disord. 2012;6(1):399–405. https://doi.org/10.1016/j.rasd.2011.06.014.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brittany E. Matheson.

Ethics declarations

Conflict of Interest

Brittany E. Matheson and Dawn M. Eichen declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Etiology of Obesity

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Matheson, B.E., Eichen, D.M. A Review of Childhood Behavioral Problems and Disorders in the Development of Obesity: Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Beyond. Curr Obes Rep 7, 19–26 (2018). https://doi.org/10.1007/s13679-018-0293-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13679-018-0293-z

Keywords

Navigation