Shifts in Food Preferences After Bariatric Surgery: Observational Reports and Proposed Mechanisms
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Purpose of Review
Bariatric surgery is currently the most effective treatment for obesity. Roux-en-Y gastric bypass (RYGB) is the most commonly performed bariatric procedure and results in long-term weight loss. Alterations in food preference and choices may contribute to the long-term benefits of RYGB. This manuscript reviews the available literature documenting changes in food preference in both humans and experimental animals after RYGB and discusses the current theory on the underlying mechanisms involved.
Obesity is associated with an increased preference for sweet and high-fat foods, and the most consistent evidence has been the shift away from these calorie-dense foods in both animal and human studies after RYGB. Self-reporting is the most common method used to record food preferences in humans, while more direct approaches have been used in animal work. This methodological heterogeneity may give rise to inconsistent findings.
Future studies in humans should focus on direct measures to permit corroboration of mechanistic insights gained from animal studies.
KeywordsFood preferences RYGB Bariatric surgery Gut hormones Taste
Funding at the Dublin laboratory arose from a Science Foundation Ireland President of Ireland Young Researcher Award to C.W. le Roux (12/YI/B2480) and the Health Research Board (USIRL-2016-2). C.W. le Roux (PI) and N.G. Docherty are coinvestigators on a grant from the Swedish Research Council (Medicine and Health) (2015-02733) at the University of Gothenburg.
Compliance with Ethical Standards
Conflict of Interest
Natasha Kapoor declares that she has no conflict of interest.
Werd Al-Najim declares that she has no conflict of interest.
Carel W. le Roux has received compensation from NovoNordisk, Johnson & Johnson and GI Dynamics for service on advisory boards and speaker’s honorarium from MSD.
Neil G. Docherty declares that he has no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of Importance
- 5.le Roux C, Neff K. Future prospects of the management of appetite disorders. Neuroendocrinology of Appetite 2016:224–46.Google Scholar
- 16.Olbers T, Bjorkman S, Lindroos A, Maleckas A, Lonn L, Sjostrom L, et al. Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial. Ann Surg. 2006;244(5):715–22.CrossRefPubMedPubMedCentralGoogle Scholar
- 17.Le Roux CW, Bueter M, Theis N, Werling M, Ashrafian H, Löwenstein C, et al. Gastric bypass reduces fat intake and preference. Am J Phys Regul Integr Comp Phys. 2011;301(4):R1057–R66.Google Scholar
- 22.• Molin Netto BD, Earthman CP, Farias G, Landi Masquio DC, Grotti Clemente AP, Peixoto P, et al. Eating patterns and food choice as determinant of weight loss and improvement of metabolic profile after RYGB. Nutrition. 2016. Recent study showing changes in specific food item preferences after RYGB 6 months post-operatively. Google Scholar
- 25.Faulconbridge LF, Ruparel K, Loughead J, Allison KC, Hesson LA, Fabricatore AN, et al. Changes in neural responsivity to highly palatable foods following Roux-en-Y gastric bypass, sleeve gastrectomy, or weight stability: an fMRI study. Obesity (Silver Spring). 2016;24(5):1054–60.CrossRefPubMedCentralGoogle Scholar
- 26.• Ochner CN, Stice E, Hutchins E, Afifi L, Geliebter A, Hirsch J, et al. Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience. 2012;209:128–35. The study targeted the ventral tagmental area (VTA) of the brain before and after RYGB and VSG to observe signal changes for low-calorie foods and high-calorie foods. The results showed a decrease in signalling for high-calorie foods 6 months after surgery in comparison to that for low-calorie foods therefore showing the importance of VTA in food palatability CrossRefPubMedPubMedCentralGoogle Scholar
- 28.• Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, et al. Roux-En-Y gastric bypass and sleeve gastrectomy does not affect food preferences when assessed by an ad libitum buffet meal. Obesity surgery. 2017. The study was the first to use direct measurement to assess food preferences in patients before and after RYGB and sleeve gastrectomy. Provides insight into targeting direct behaviour to assess eating behaviour. Google Scholar
- 33.• Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC. Roux-en-Y gastric bypass in rats progressively decreases the proportion of fat calories selected from a palatable cafeteria diet. Am J Physiol Regulatory, Integrative Comparative Physiol. 2016;310(10):R952–R9. The study provided a ‘cafeteria diet’ to rats before and after RYGB and saw a decrease in total calorie and percentage calorie from fat intake in comparison to those in the sham surgery group. There was an increase in carbohydrate consumption in the RYGB group when compared to that in the sham surgery group. The study highlighted dietary shifts and found that majority of the calories even after surgery came from food items rich in fat and sugars CrossRefGoogle Scholar
- 36.Makaronidis JM, Neilson S, Cheung WH, Tymoszuk U, Pucci A, Finer N, et al. Reported appetite, taste and smell changes following Roux-en-Y gastric bypass and sleeve gastrectomy: effect of gender, type 2 diabetes and relationship to post-operative weight loss. Appetite. 2016;107:93–105.CrossRefPubMedGoogle Scholar
- 44.Hyde KM, Blonde GD, le Roux CW, Spector AC. Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection. Physiol Behav. 2017;Google Scholar
- 48.Zheng H, Shin AC, Lenard NR, Townsend RL, Patterson LM, Sigalet DL, et al. Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. Am J Phys Regul Integr Comp Phys. 2009;297(5):R1273–R82.Google Scholar
- 49.Mathes CM, Bueter M, Smith KR, Lutz TA, Le Roux CW, Spector AC. Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation. Am J Phys Regul Integr Comp Phys. 2012;302(6):R751–R67.Google Scholar
- 52.Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, et al. Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiol Behav. 2015;142:179–88.CrossRefPubMedPubMedCentralGoogle Scholar
- 54.Mathes CM, Bohnenkamp RA, le Roux CW, Spector AC. Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency. Am J Physiol Regul Integr Comp Physiol. 2015;309(8):R864–74.CrossRefPubMedPubMedCentralGoogle Scholar