Current Obesity Reports

, Volume 4, Issue 4, pp 389–400 | Cite as

Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

  • Fernando F. Anhê
  • Thibault V. Varin
  • Mélanie Le Barz
  • Yves Desjardins
  • Emile Levy
  • Denis Roy
  • André MaretteEmail author
Metabolism (P Trayhurn, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Metabolism


Trillions of microorganisms inhabit the human body, strongly colonizing the gastro-intestinal tract and outnumbering our own cells. High-throughput sequencing techniques and new bioinformatic tools have enabled scientists to extend our knowledge on the relationship between the gut microbiota and host’s physiology. Disruption of the ecological equilibrium in the gut (i.e., dysbiosis) has been associated with several pathological processes, including obesity and its related comorbidities, with diet being a strong determinant of gut microbial balance. In this review, we discuss the potential prebiotic effect of polyphenol-rich foods and extracts and how they can reshape the gut microbiota, emphasizing the novel role of the mucin-degrading bacterium Akkermansia muciniphila in their metabolic benefits.


Prebiotics Polyphenols Obesity Insulin resistance Akkermansia 


Compliance with Ethics Guidelines

Conflict of Interest

Fernando F. Anhê, Thibault V. Varin, Mélanie Le Barz, Yves Desjardins, Emile Levy, Denis Roy, and André Marette declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Fernando F. Anhê
    • 1
    • 2
    • 5
  • Thibault V. Varin
    • 2
  • Mélanie Le Barz
    • 1
    • 2
    • 5
  • Yves Desjardins
    • 2
  • Emile Levy
    • 2
    • 3
    • 4
  • Denis Roy
    • 2
  • André Marette
    • 1
    • 2
    • 5
    Email author
  1. 1.Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung InstituteLaval UniversityQuebecCanada
  2. 2.Institute of Nutrition and Functional Foods (INAF)Laval UniversityQuébecCanada
  3. 3.Research Centre, CHU-Sainte-Justine and Department of NutritionUniversité de MontréalMontrealCanada
  4. 4.Department of Nutrition, Faculty of MedicineUniversity of MontrealMontrealCanada
  5. 5.Hôpital Laval, Pavillon Marguerite d’YouvilleQuebecCanada

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