Current Obesity Reports

, Volume 3, Issue 4, pp 422–431 | Cite as

Low-Grade Inflammation, Obesity, and Diabetes

  • Solange S. Pereira
  • Jacqueline I. Alvarez-Leite
Metabolism (R Pasquali, Section Editor)

Abstract

Obesity and its comorbidities are closely related to the inflammatory environment created by expanded adipose tissue. Several mechanisms trigger inflammation in adipose tissue, including excess fatty acids, hypoxia, and activation of the inflammasome. Inflammation is characterized by the abundance of immune cells, particularly M1 macrophages and T lymphocytes, which have increased secretion of proinflammatory cytokines that act to perpetuate systemic inflammation and induce insulin resistance. The gut microbiota is also involved in obesity-induced inflammation via LPS-related endotoxemia that induces cytokine secretion and insulin resistance. Innate lymphoid type 2 cells, regulatory T cells, and interleukine (IL)-10 counteract the inflammation and insulin resistance, establishing classical or metabolically healthy obesity.

Keywords

Obesity Inflammation Macrophages Metabolic syndrome Type 2 diabetes mellitus Adipokines 

Notes

Compliance with Ethics Guidelines

Conflicts of Interest

Solange S. Pereira and Jacqueline I Alvarez-Leite declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Solange S. Pereira
    • 1
  • Jacqueline I. Alvarez-Leite
    • 1
  1. 1.Department Biochemistry and ImmunologyUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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