Evidence-Based Review of Clinical Applications and Outcomes of Automated Epidermal Grafting
- 7 Downloads
Purpose of Review
Commercialization of an automated epidermal harvesting device (CelluTome™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes.
A total of 20 published reports including 284 automated graft recipients have been published. Complete reepithelialization occurs in 50–92% of recipient sites, often within 4–18 weeks of graft placement. Donor sites heal without scarring within 1–2 weeks.
Current evidence suggests efficacy in using an automated epidermal harvesting device for the wounds of patients with multiple comorbidities and failing previous treatments for their wounds, including vascular ulcers, diabetic ulcers, surgical wounds, complex wounds, acute traumatic wounds, pyoderma gangrenosum, and burns. Limited evidence also suggests efficacy of automated epidermal grafting for disorders of pigmentation. Better trials studying individual clinical applications of epidermal grafting are needed.
KeywordsEpidermal skin graft Wound healing Vitiligo Pigmentation disorders
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
- 22.• Lincoln K, Hyde J. Evaluation of epidermal skin grafts for the treatment of complex wounds in a wound care center: a 94-patient case series. Wounds. 2016;28:347–53 Largest sample of wounds treated with automated epidermal harvesting and grafting published to date. Describes infection in 25/90 treated wounds. PubMedGoogle Scholar
- 27.• Smith OJ, Edmondson S-J, Bystrzonowski N, Hachach-Haram N, Kanapathy M, Richards T, et al. The CelluTome epidermal graft-harvesting system: a patient-reported outcome measure and cost evaluation study. Int Wound J. 2017;14:555–60 Describes graft failure in 2 immunocompromised patients. CrossRefGoogle Scholar
- 29.Study of cellutome system for treatment of individual lesions in EB Pts [Internet]. [cited 2018 Jul 11]. Available from: https://clinicaltrials.gov/ct2/show/NCT02670837.
- 30.Study comparing healing with epidermal fractional blistergrafting (CellutomeTM) to acellular technique [Internet]. [cited 2018 Jul 11]. Available from: https://clinicaltrials.gov/ct2/show/NCT02982096.
- 31.Clinical trial to evaluate blister graft utilizing a novel harvesting device for treatment of venous leg ulcers [Internet]. [cited 2018 Jul 11]. Available from: https://clinicaltrials.gov/ct2/show/NCT02148302.
- 34.Twyman L. Epidermal harvesting in plastic surgery outpatients -an interdisciplinary team approach. Wounds UK. 2016;12:69–75.Google Scholar