Current Dermatology Reports

, Volume 7, Issue 4, pp 287–295 | Cite as

Wound Healing with Botanicals: a Review and Future Perspectives

  • Cassandra L. QuaveEmail author
Wound Care and Healing (H Lev-Tov, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Wound Care and Healing


Purpose of Review

Botanicals have long played a crucial role in the management of chronic and infected wounds, yet the mechanistic basis of these therapies remains largely poorly understood by modern science.

Recent Findings

Studies have begun to unveil the mechanistic bases of botanical therapies for wound healing, but more work is necessary. Most notably, investigation into the growing conditions, post-harvest treatment, and pharmacological preparation of these botanicals has demonstrated their importance in terms of the chemical makeup and pharmacological activity of the final product used in pre-clinical and clinical studies.


This work evaluates the potential safety, efficacy, and mechanistic basis of some key botanical ingredients used in traditional medicine for wound care: aloe, marigold, and St. John’s Wort. Furthermore, perspectives on the future role that botanical natural products may play in anti-infective and wound care, innovations are explored.


Wounds Botanicals Wound healing Medicinal plants Complementary medicine Infection 


Funding information

Work in the Quave Research Group is funded by the National Institutes of Health, National Institute of Allergy and Infectious Disease (R21 AI136563, PI: CLQ). The funding agency had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The author is an inventor on patents concerning botanical inhibitors of microbial biofilm formation and quorum sensing; the author confirms that any competing interests do not alter her adherence to journal policies on ethics and sharing data or materials. The author provided consulting services to Medline during the period of writing this study. The author declares that provision of these services did not have any impact on the present study.

Dr. Quave reports grants from National Institutes of Health, National Institute of Allergy and Infectious Disease, from null, during the conduct of the study; personal fees from Medline, from null, outside the submitted work. In addition, Dr. Quave has a patent Quave, C.L., M.S. Smeltzer, C.M. Compadre, H. Hendrickson. Anti-biofilm compositions and methods for using Patent Numbers: WO2012048119-A2; US2012088671-A1; WO2012048119-A3. Derwent Primary Accession No.: 2012-E22562; Issued June 3, 2014; US 9,351,492 B2 Issued May 31, 2016 issued, a patent Quave, C.L., A.R. Horswill, J.T. Lyles. Botanical extracts and compounds from Castanea plants and methods of use. Provisional Filed June 26, 2015. Serial No. 62/185,146. Non-Provisional Filed June 24, 2016 Serial No. 15/195,514 pending, and a patent Quave, C.L. and J.T. Lyles. Botanical extracts and compounds from Schinus plants and methods of use. Provisional filed July 10, 2015; serial no. 62/190,802; non-provisional filed July 8, 2016; serial no. 15/205,493, pending.

Ethics Statement

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


The content is solely the responsibility of the authors and does not necessarily reflect the official views of the NIH or NIAID.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyEmory University School of MedicineAtlantaUSA
  2. 2.Center for the Study of Human HealthEmory University College of Arts and SciencesAtlantaUSA
  3. 3.Emory University HerbariumAtlantaUSA

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