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Current Dermatology Reports

, Volume 7, Issue 4, pp 278–286 | Cite as

Use of Stem Cells in Wound Healing

  • Adam Aronson
  • Leah Laageide
  • Jennifer Powers
Wound Care and Healing (H Lev-Tov, Section Editor)
  • 56 Downloads
Part of the following topical collections:
  1. Topical Collection on Wound Care and Healing

Abstract

Purpose of Review

This review provides an overview of the principal stages of wound healing, the populations of endogenous and therapeutic stem cells, applications of stem cells in specific types of wounds, and current approaches of stem cell delivery for tissue regeneration.

Recent Findings

New uses of progenitor stem cells have been developed for the treatment of wounds. Stem cells improve wound healing through both local and paracrine effects. Stem cell populations of therapeutic utility include embryonic stem cells, induced pluripotent stem cells, adult bone marrow and adipose-derived mesenchymal stem cells, as well as stem cells from skin, cord blood, and extra fetal tissue. Induced pluripotent stem cells mitigate many of the ethical and immunogenic concerns related to use of embryonically derived stem cells.

Summary

Skin, the largest organ in the human body, serves as a protective barrier for mammals. Both aging and disease contribute to loss of skin barrier function, which can result in consequences such as chronic wounds. Recent advances in many types of stem cell therapy may revolutionize treatment of difficult wounds. Optimal techniques for obtaining and delivering stem cells are still being refined.

Keywords

Stem cells Wound healing Chronic wounds Biologic therapies 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  2. 2.Carver College of MedicineUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  3. 3.Department of DermatologyUniversity of Iowa Hospitals and Clinics and VA Medical CenterIowa CityUSA

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