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Current Dermatology Reports

, Volume 4, Issue 2, pp 83–89 | Cite as

Pediatric Urticaria

  • Petra StaubachEmail author
  • Tom Gilfert
Urticaria (P Staubach, Section Editor)
  • 165 Downloads
Part of the following topical collections:
  1. Topical Collection on Urticaria

Abstract

Urticaria in childhood is a heterogeneous disease with multiple subgroups. It is a common disease, and like in all itchy skin diseases, it has a great impact on quality of life. Epidemiological studies and available literature for pediatric urticaria is scarce, and valid data is still missing in many aspects. There seem to be no differences in the underlying causes of spontaneous urticaria between children and adults. The main focus in treating children as well as adults with urticaria is to get the patient free of symptoms and to treat the disease until it is gone. Further research is needed to provide more causal therapy options and increase quality of life in children with urticaria.

Keywords

Pediatric Urticaria Children Treatment Diagnostics 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Petra Staubach is member of an Novartis Advisory Board and is giving talks sponsored by Novartis. Tom Gilfert declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. 1.•
    Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW. The EAACI/GA(2) LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014;69(7):868–87. This guideline recommends diagnostic and therapeutic pathways.CrossRefPubMedGoogle Scholar
  2. 2.
    Staubach P, Dechene M, Metz M, Magerl M, Siebenhaar F, Weller K, et al. High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Derm Venereol. 2011;91(5):557–61.PubMedGoogle Scholar
  3. 3.
    Ferrer M. Epidemiology, healthcare, resources, use and clinical features of different types of urticaria. Alergológica 2005. J Investig Allergol Clin Immunol. 2009;19 Suppl 2:21–6.PubMedGoogle Scholar
  4. 4.
    Marrouche N, Grattan C. Childhood urticaria. Curr Opin Allergy Clin Immunol. 2012;12(5):485–90.CrossRefPubMedGoogle Scholar
  5. 5.
    Brüske I, Standl M, Weidinger S, Klümper C, Hoffmann B, Schaaf B, et al. Epidemiology of urticaria in infants and young children in Germany—results from the German LISAplus and GINIplus birth cohort studies. Pediatr Allergy Immunol. 2014;25(1):36–42.CrossRefPubMedGoogle Scholar
  6. 6.
    Kjaer HF, Eller E, Høst A, Andersen KE, Bindslev-Jensen C. The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatr Allergy Immunol. 2008;19(8):737–45.CrossRefPubMedGoogle Scholar
  7. 7.
    Konstantinou GN, Papadopoulos NG, Tavladaki T, Tsekoura T, Tsilimigaki A, Grattan CEH. Childhood acute urticaria in northern and southern Europe shows a similar epidemiological pattern and significant meteorological influences. Pediatr Allergy Immunol. 2011;22(1 Pt 1):36–42.CrossRefPubMedGoogle Scholar
  8. 8.
    Volonakis M, Katsarou-Katsari A, Stratigos J. Etiologic factors in childhood chronic urticaria. Ann Allerg. 1992;69(1):61–5.PubMedGoogle Scholar
  9. 9.
    Maurer M, Bindslev-Jensen C, Gimenez-Arnau A, Godse K, Grattan CEM, Hide M, et al. Chronic idiopathic urticaria (CIU) is no longer idiopathic: time for an update. Br J Dermatol. 2013;168(2):455–6.CrossRefPubMedGoogle Scholar
  10. 10.
    Chansakulporn S, Pongpreuksa S, Sangacharoenkit P, Pacharn P, Visitsunthorn N, Vichyanond P, et al. The natural history of chronic urticaria in childhood: a prospective study. J Am Acad Dermatol. 2014;71(4):663–8.CrossRefPubMedGoogle Scholar
  11. 11.
    Caffarelli C, Cuomo B, Cardinale F, Barberi S, Dascola CP, Agostinis F, et al. Aetiological factors associated with chronic urticaria in children: a systematic review. Acta Derm Venereol. 2013;93(3):268–72.CrossRefPubMedGoogle Scholar
  12. 12.
    Pite H, Wedi B, Borrego LM, Kapp A, Raap U. Management of childhood urticaria: current knowledge and practical recommendations. Acta Derm Venereol. 2013;93(5):500–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Ricci G, Giannetti A, Belotti T, Dondi A, Bendandi B, Cipriani F, et al. Allergy is not the main trigger of urticaria in children referred to the emergency room. J Eur Acad Dermatol Venereol. 2010;24(11):1347–8.CrossRefPubMedGoogle Scholar
  14. 14.•
    Maurer PDM, Magerl M, Metz M, Zuberbier T. Diagnostik und Therapie der chronischen Urtikaria – Was wird von Revision und Aktualisierung der internationalen Leitlinie erwartet? Hautarzt. 2013;64(9):638–43. This report recommends diagnostic pathways.CrossRefPubMedGoogle Scholar
  15. 15.
    Sackesen C, Sekerel BE, Orhan F, Kocabas CN, Tuncer A, Adalioglu G. The etiology of different forms of urticaria in childhood. Pediatr Dermatol. 2004;21(2):102–8.CrossRefPubMedGoogle Scholar
  16. 16.
    Akelma AZ, Cizmeci MN, Mete E, Tufan N, Bozkurt B. A neglected cause for chronic spontaneous urticaria in children: Helicobacter pylori. Allergol Immunopathol (Madr). 2014 Mar 20Google Scholar
  17. 17.
    Sahiner UM, Civelek E, Tuncer A, Yavuz ST, Karabulut E, Sackesen C, et al. Chronic urticaria: etiology and natural course in children. Int Arch Allergy Immunol. 2011;156(2):224–30.CrossRefPubMedGoogle Scholar
  18. 18.
    Harris A, Twarog FJ, Geha RS. Chronic urticaria in childhood: natural course and etiology. Ann Allerg. 1983;51(2 Pt 1):161–5.PubMedGoogle Scholar
  19. 19.
    Martino M, Peruzzi M, Galli L, Lega L, Zammarchi E, Vierucci A. Food-additive intolerance and its correlation with atopy in children with recurrent or intermittent urticaria-angioedema. Pediatr Allergy Immunol. 1992;3:33–8.CrossRefGoogle Scholar
  20. 20.
    Brunetti L, Francavilla R, Miniello VL, Platzer MH, Rizzi D, Lospalluti ML, et al. High prevalence of autoimmune urticaria in children with chronic urticaria. J Allergy Clin Immunol. 2004;114(4):922–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Kilic G, Guler N, Suleyman A, Tamay Z. Chronic urticaria and autoimmunity in children. Pediatr Allergy Immunol. 2010;21(5):837–42.CrossRefPubMedGoogle Scholar
  22. 22.
    Du Toit G, Prescott R, Lawrence P, Johar A, Brown G, Weinberg EG, et al. Autoantibodies to the high-affinity IgE receptor in children with chronic urticaria. Ann Allergy Asthma Immunol. 2006;96(2):341–4.CrossRefPubMedGoogle Scholar
  23. 23.
    Khakoo G, Sofianou-Katsoulis A, Perkin MR, Lack G. Clinical features and natural history of physical urticaria in children. Pediatr Allergy Immunol. 2008;19(4):363–6.CrossRefPubMedGoogle Scholar
  24. 24.
    Beattie PE, Dawe RS, Ibbotson SH, Ferguson J. Characteristics and prognosis of idiopathic solar urticaria: a cohort of 87 cases. Arch Dermatol. 2003;139(9):1149–54.CrossRefPubMedGoogle Scholar
  25. 25.
    Simons FER. Early prevention of asthma in atopic children study group. H1-antihistamine treatment in young atopic children: effect on urticaria. Ann Allergy Asthma Immunol. 2007;99(3):261–6.CrossRefPubMedGoogle Scholar
  26. 26.
    Simons FER. Early prevention of asthma in atopic children (EPAAC) study group. Safety of levocetirizine treatment in young atopic children: an 18-month study. Pediatr Allergy Immunol. 2007;18(6):535–42.CrossRefPubMedGoogle Scholar
  27. 27.
    Church MK, Maurer M, Simons FER, Bindslev-Jensen C, van Cauwenberge P, Bousquet J, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459–66.CrossRefPubMedGoogle Scholar
  28. 28.
    Licari A, Marseglia A, Caimmi S, Castagnoli R, Foiadelli T, Barberi S, et al. Omalizumab in children. Paediatr Drugs. 2014;16(6):491–502.CrossRefPubMedCentralPubMedGoogle Scholar
  29. 29.
    Neverman L, Weinberger M. Treatment of chronic urticaria in children with antihistamines and cyclosporine. J Allergy Clin Immunol Pract. 2014;2(4):434–8.CrossRefPubMedGoogle Scholar
  30. 30.
    Muraro A, Dubois AEJ, DunnGalvin A, Hourihane JO, de Jong NW, Meyer R, et al. EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures. Allergy. 2014;69(7):845–53.CrossRefPubMedGoogle Scholar
  31. 31.
    Staubach P, Groffik A. Useful tools for documenting urticaria. Hautarzt. 2013;64(9):650–5.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of DermatologyUniversity Medical Center of MainzMainzGermany

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