Current Dermatology Reports

, Volume 3, Issue 1, pp 6–12

Allergy to Hematophagous Arthropods Bites

Immunology (HC Lima, Section Editor)


Allergies to hematophagous arthropod bites are inflammatory reactivity to arthropods salivary components. They vary in intensity and quality dependent upon the arthropod species and the individual immune response to specific proteins of the insect’s saliva. Individuals who were not previously exposed show mild localized reactions not beyond those expected by pharmacological substances present in arthropods’ saliva. Allergic reactions are immunological in their nature and the diversity derived from hypersensitivity reactions with different levels of participation of the immune system components. Some are mainly derived from a humoral immune response, and others are based predominantly on T-lymphocyte-mediated. The majority of these undesired biological answers are self-limited, and few may cause a systemic reaction. This article intends to discuss the immunological ingredients of this evolutionary interaction.


Insect bites and stings Insect proteins Hypersensitivity Salivary proteins and peptides Arthropods 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Departamento de Dermatologia, SNUnesp Medical SchoolBotucatuBrazil
  2. 2.Division of Dermatology, Department of Medicine - Michael G. DeGroote School of MedicineMcMaster UniversityWest HamiltonCanada

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