Current Status of Multipurpose Prevention Technology (MPT) Development

  • Cynthia Woodsong
  • Jonathon Holt
  • Brid Devlin
  • Zeda Rosenberg
Family Planning (A Burke, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Family Planning


Multipurpose prevention technologies (MPTs) are pharmaceutical products being developed for multiple indications, primarily prevention of HIV, pregnancy, and/or sexually transmitted infections. MPT products could be a combination of multiple drugs co-formulated for separate indications, or a single product with multiple indications. This paper reviews MPT work published since 2013, including technical papers on aspects of product development, papers focused on issues that will be critical to future MPT clinical research and introduction, and selected papers concerning products for prevention of pregnancy or HIV/STIs. Collaborative efforts between researchers and funders aim to provide efficiencies in the product development process, building on experiences from both the contraceptive and vaginal microbicide fields.


Multipurpose prevention technology HIV prevention Contraception STI prevention Microbicides 


Compliance with Ethics Guidelines

Conflict of Interest

Cynthia Woodsong, Brid Devlin, and Zeda Rosenberg report grants from the Bill and Melinda Gates Foundation, grants from the United States Agency for International Development, grants from United Kingdom AID, grants from the Netherlands Ministry of Foreign Affairs , grants from the Danish Ministry of Foreign Affairs, grants from Irish AID, and grants from the Norwegian Ministry of Foreign Affairs. In addition, they report that they have US Patent 8,580,294B2 issued to International Partnership for Microbicides, and US Patent 61/904,073 pending.

Jonathon Holt reports grants from the Bill and Melinda Gates Foundation, grants from the United States Agency for International Development, grants from United Kingdom AID, grants from the Netherlands Ministry of Foreign Affairs, grants from the Danish Ministry of Foreign Affairs, grants from Irish AID, and grants from the Norwegian Ministry of Foreign Affairs. In addition, Dr. Holt has US Patent 61/904,073 pending.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.•
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    Harrison PF, Hemmerling A, Romano J, Whaley KJ, Holt BY. Developing multipurpose reproductive health technologies: an integrated strategy. AIDS Res Treat. 2013;2013:790154. doi: 10.1155/2013/790154. Harrison et al. provided a succinct summary of MPT development efforts. This paper is an essential “go-to” for anyone interested in MPTs. The paper includes a number of tables with important details about MPT development, including a table summarizing the regional needs and priorities for MPTs.
  4. 4.••
    Lusti-Narasimhan M, ed. Multipurpose Prevention Technologies: Maximising Positive Synergies Br J Obstet Gynaec. 2014;121, Suppl. 5. This special issue of BJOG includes “editorials, commentaries, review articles and original research focussing on the current progress in developing and promoting multipurpose prevention technologies.” There are 16 articles in the issue, which together provide a comprehensive overview of MPT development efforts.Google Scholar
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Cynthia Woodsong
    • 1
  • Jonathon Holt
    • 1
  • Brid Devlin
    • 1
  • Zeda Rosenberg
    • 1
  1. 1.International Partnership for MicrobicidesSilver SpringUSA

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