Current Status of Multipurpose Prevention Technology (MPT) Development
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Multipurpose prevention technologies (MPTs) are pharmaceutical products being developed for multiple indications, primarily prevention of HIV, pregnancy, and/or sexually transmitted infections. MPT products could be a combination of multiple drugs co-formulated for separate indications, or a single product with multiple indications. This paper reviews MPT work published since 2013, including technical papers on aspects of product development, papers focused on issues that will be critical to future MPT clinical research and introduction, and selected papers concerning products for prevention of pregnancy or HIV/STIs. Collaborative efforts between researchers and funders aim to provide efficiencies in the product development process, building on experiences from both the contraceptive and vaginal microbicide fields.
KeywordsMultipurpose prevention technology HIV prevention Contraception STI prevention Microbicides
Compliance with Ethics Guidelines
Conflict of Interest
Cynthia Woodsong, Brid Devlin, and Zeda Rosenberg report grants from the Bill and Melinda Gates Foundation, grants from the United States Agency for International Development, grants from United Kingdom AID, grants from the Netherlands Ministry of Foreign Affairs , grants from the Danish Ministry of Foreign Affairs, grants from Irish AID, and grants from the Norwegian Ministry of Foreign Affairs. In addition, they report that they have US Patent 8,580,294B2 issued to International Partnership for Microbicides, and US Patent 61/904,073 pending.
Jonathon Holt reports grants from the Bill and Melinda Gates Foundation, grants from the United States Agency for International Development, grants from United Kingdom AID, grants from the Netherlands Ministry of Foreign Affairs, grants from the Danish Ministry of Foreign Affairs, grants from Irish AID, and grants from the Norwegian Ministry of Foreign Affairs. In addition, Dr. Holt has US Patent 61/904,073 pending.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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- 56.•Blakney AK, Krogstad EA, Jiang YH, Woodrow KA. Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures. Int J Nanomedicine. 2014;9:2967. Blackney et al., provided an overview of technical considerations for development of electrospun nanofibers for MPT drug delivery. Although this technology is at an early stage of development, adherence problems observed with current delivery modes prompt interest in increasing the options for drug delivery.CrossRefPubMedCentralPubMedGoogle Scholar
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