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Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms

  • Manami InoueEmail author
  • Shoichiro Tsugane
Cancer (MF Leitzmann, Section Editor)
  • 11 Downloads
Part of the following topical collections:
  1. Topical Collection on Cancer

Abstract

Purpose of Review

We reviewed the available literature on observational studies, meta-analyses, expert reports, and umbrella reviews. Here, we summarize the latest findings on the association between coffee intake and liver cancer risk.

Recent Findings

Most observational studies and meta-analyses show a protective effect of coffee intake on liver cancer risk, with dose-responsiveness and across different populations, and regardless of hepatitis virus infection status. Risk reduction by coffee consumption has also been observed for chronic liver diseases. Potential mechanisms include the effect of a number of bioactive compounds such as caffeine, chlorogenic acids, phenolic compounds and diterpenes; antioxidant properties; induction of defense mechanisms; and anti-inflammatory properties. Other potential mechanisms include improvement in insulin sensitivity and prevention of metabolic syndrome and diabetes.

Summary

Accumulated evidence, with consistency across study designs and populations, suggests that coffee intake probably reduces the risk of liver cancer. Future research should aim to elucidate the mechanism of this preventive effect with establishing the causality of an association.

Keywords

Coffee Liver cancer Epidemiology Reduced risk Dose-response Mechanism Causality 

Notes

Compliance with Ethical Standards

Conflict of Interest

Manami Inoue and Shoichiro Tsugane declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. 1.
    Yanagimoto K, Ochi H, Lee KG, Shibamoto T. Antioxidative activities of fractions obtained from brewed coffee. J Agric Food Chem. 2004;52(3):592–6.CrossRefGoogle Scholar
  2. 2.
    Urgert R, Schulz AG, Katan MB. Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. Am J Clin Nutr. 1995;61(1):149–54.CrossRefGoogle Scholar
  3. 3.
    Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr. 2017;37:131–56.CrossRefGoogle Scholar
  4. 4.
    Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024.CrossRefGoogle Scholar
  5. 5.
    Bravi F, Bosetti C, Tavani A, Bagnardi V, Gallus S, Negri E, et al. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology. 2007;46(2):430–5.CrossRefGoogle Scholar
  6. 6.
    Bravi F, Bosetti C, Tavani A, Gallus S, La Vecchia C. Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clin Gastroenterol Hepatol. 2013;11(11):1413–21 e1.CrossRefGoogle Scholar
  7. 7.
    Bravi F, Tavani A, Bosetti C, Boffetta P, La Vecchia C. Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies. Eur J Cancer Prev. 2017;26(5):368–77.CrossRefGoogle Scholar
  8. 8.
    • Godos J, Micek A, Marranzano M, Salomone F, Rio DD, Ray S. Coffee consumption and risk of biliary tract cancers and liver cancer: a dose-response meta-analysis of prospective cohort studies. Nutrients. 2017;9(9):950 The most recent meta-analysis of both cohort and case-control studies showed significant inverse relation between coffee consumption and the risk of liver cancer. CrossRefGoogle Scholar
  9. 9.
    Larsson SC, Wolk A. Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology. 2007;132(5):1740–5.CrossRefGoogle Scholar
  10. 10.
    Yu X, Bao Z, Zou J, Dong J. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer. 2011;11:96.CrossRefGoogle Scholar
  11. 11.
    2018 Third Expert Report, Diet, Nutrition, Physical Activity and Cancer: a Global Perspective: World Cancer Research Fund/American Institute for Cancer Research; 2018.Google Scholar
  12. 12.
    Continuous Update Project Expert Report 2018. Diet, nutrition, physical activiey and liver cancer. : World Cancer Research Fund/American Institute for Cancer Research; 2018.Google Scholar
  13. 13.
    • Continuous Update Project Expert Report 2018. Non-alcoholic drinks and the risk of cancer: World Cancer Research Fund/American Institute for Cancer Research; 2018. The WCRF/AICR CUP updated its evaluation on the effect of coffee on the risk of cancer in their CUP in 2015 and 2018 with inclusion of recent available evidence, which strongly indicates that consuming coffee decreases the risk of liver cancer. Accordingly, the CUP Panel concluded that consumption of coffee “probably” protects against liver cancer. Google Scholar
  14. 14.
    IARC Monographs on the evaluation of carcinogenic risks to humans, volume 116 Drinking coffee, mate, and very hot beverages: World Health Organization; 2018.Google Scholar
  15. 15.
    Alicandro G, Tavani A, La Vecchia C. Coffee and cancer risk: a summary overview. Eur J Cancer Prev. 2017;26(5):424–32.CrossRefGoogle Scholar
  16. 16.
    Inoue M, Yoshimi I, Sobue T, Tsugane S. The Japan Public-Health Center-based Prospective Study Group. Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst. 2005;97(4):293–300.CrossRefGoogle Scholar
  17. 17.
    Kurozawa Y, Ogimoto I, Shibata A, Nose T, Yoshimura T, Suzuki H, et al. Coffee and risk of death from hepatocellular carcinoma in a large cohort study in Japan. Br J Cancer. 2005;93(5):607–10.CrossRefGoogle Scholar
  18. 18.
    Shimazu T, Tsubono Y, Kuriyama S, Ohmori K, Koizumi Y, Nishino Y, et al. Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan. Int J Cancer. 2005;116(1):150–4.CrossRefGoogle Scholar
  19. 19.
    Iso H, Kubota Y, Japan Collaborative Cohort Study for Evaluation of C. Nutrition and disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). Asian Pac J Cancer Prev. 2007;8(Suppl):35–80.PubMedGoogle Scholar
  20. 20.
    Inoue M, Kurahashi N, Iwasaki M, Shimazu T, Tanaka Y, Mizokami M, et al. Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Cancer Epidemiol Biomark Prev. 2009;18(6):1746–53.CrossRefGoogle Scholar
  21. 21.
    Johnson S, Koh WP, Wang R, Govindarajan S, Yu MC, Yuan JM. Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study. Cancer Causes Control. 2011;22(3):503–10.CrossRefGoogle Scholar
  22. 22.
    Bamia C, Lagiou P, Jenab M, Trichopoulou A, Fedirko V, Aleksandrova K, et al. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study. Int J Cancer. 2015;136(8):1899–908.CrossRefGoogle Scholar
  23. 23.
    Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology. 2015;148(1):118–25 quiz e15.CrossRefGoogle Scholar
  24. 24.
    Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, et al. Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study. Cancer Epidemiol Biomark Prev. 2008;17(4):846–54.CrossRefGoogle Scholar
  25. 25.
    Lai GY, Weinstein SJ, Albanes D, Taylor PR, McGlynn KA, Virtamo J, et al. The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers. Br J Cancer. 2013;109(5):1344–51.CrossRefGoogle Scholar
  26. 26.
    Petrick JL, Freedman ND, Graubard BI, Sahasrabuddhe VV, Lai GY, Alavanja MC, et al. Coffee consumption and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma by sex: the Liver Cancer Pooling Project. Cancer Epidemiol Biomark Prev. 2015;24(9):1398–406.CrossRefGoogle Scholar
  27. 27.
    Wakai K, Kurozawa Y, Shibata A, Fujita Y, Kotani K, Ogimoto I, et al. Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan. Br J Cancer. 2007;97(3):426–8.CrossRefGoogle Scholar
  28. 28.
    Aleksandrova K, Bamia C, Drogan D, Lagiou P, Trichopoulou A, Jenab M, et al. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2015;102(6):1498–508.CrossRefGoogle Scholar
  29. 29.
    Hu G, Tuomilehto J, Pukkala E, Hakulinen T, Antikainen R, Vartiainen E, et al. Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer. Hepatology. 2008;48(1):129–36.CrossRefGoogle Scholar
  30. 30.
    Tanaka K, Hara M, Sakamoto T, Higaki Y, Mizuta T, Eguchi Y, et al. Inverse association between coffee drinking and the risk of hepatocellular carcinoma: a case-control study in Japan. Cancer Sci. 2007;98(2):214–8.CrossRefGoogle Scholar
  31. 31.
    La Vecchia C, Ferraroni M, Negri E, D’Avanzo B, Decarli A, Levi F, et al. Coffee consumption and digestive tract cancers. Cancer Res. 1989;49(4):1049–51.PubMedGoogle Scholar
  32. 32.
    Kuper H, Tzonou A, Kaklamani E, Hsieh CC, Lagiou P, Adami HO, et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer. 2000;85(4):498–502.CrossRefGoogle Scholar
  33. 33.
    Gallus S, Bertuzzi M, Tavani A, Bosetti C, Negri E, La Vecchia C, et al. Does coffee protect against hepatocellular carcinoma? Br J Cancer. 2002;87(9):956–9.CrossRefGoogle Scholar
  34. 34.
    Gelatti U, Covolo L, Franceschini M, Pirali F, Tagger A, Ribero ML, et al. Coffee consumption reduces the risk of hepatocellular carcinoma independently of its aetiology: a case-control study. J Hepatol. 2005;42(4):528–34.CrossRefGoogle Scholar
  35. 35.
    Ohfuji S, Fukushima W, Tanaka T, Habu D, Tamori A, Sakaguchi H, et al. Coffee consumption and reduced risk of hepatocellular carcinoma among patients with chronic type C liver disease: a case-control study. Hepatol Res. 2006;36(3):201–8.CrossRefGoogle Scholar
  36. 36.
    Montella M, Polesel J, La Vecchia C, Dal Maso L, Crispo A, Crovatto M, et al. Coffee and tea consumption and risk of hepatocellular carcinoma in Italy. Int J Cancer. 2007;120(7):1555–9.CrossRefGoogle Scholar
  37. 37.
    Leung WW, Ho SC, Chan HL, Wong V, Yeo W, Mok TS. Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study. J Epidemiol Community Health. 2011;65(6):556–8.CrossRefGoogle Scholar
  38. 38.
    Jang ES, Jeong SH, Lee SH, Hwang SH, Ahn SY, Lee J, et al. The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area. Liver Int. 2013;33(7):1092–9.CrossRefGoogle Scholar
  39. 39.
    Patil PS, Mohandas KM, Bhatia SJ, Mehta SA. Serum ferritin and the risk of hepatocellular carcinoma in chronic liver disease of viral etiology: a case-control study. Indian J Gastroenterol. 2014;33(1):12–8.CrossRefGoogle Scholar
  40. 40.
    Sang LX, Chang B, Li XH, Jiang M. Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol. 2013;13:34.CrossRefGoogle Scholar
  41. 41.
    Loomis D, Guyton KZ, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, et al. Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncol. 2016;17(7):877–8.CrossRefGoogle Scholar
  42. 42.
    Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P. Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Int J Evid Based Healthc. 2015;13(3):132–40.CrossRefGoogle Scholar
  43. 43.
    Nilssen O, Forde OH. Seven-year longitudinal population study of change in gamma-glutamyltransferase: the Tromso Study. Am J Epidemiol. 1994;139(8):787–92.CrossRefGoogle Scholar
  44. 44.
    Shaposhnikov S, Hatzold T, Yamani NE, Stavro PM, Lorenzo Y, Dusinska M, et al. Coffee and oxidative stress: a human intervention study. Eur J Nutr. 2018;57(2):533–44.CrossRefGoogle Scholar
  45. 45.
    Bohn SK, Blomhoff R, Paur I. Coffee and cancer risk, epidemiological evidence, and molecular mechanisms. Mol Nutr Food Res. 2014;58(5):915–30.CrossRefGoogle Scholar
  46. 46.
    Vitaglione P, Morisco F, Mazzone G, Amoruso DC, Ribecco MT, Romano A, et al. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology. 2010;52(5):1652–61.CrossRefGoogle Scholar
  47. 47.
    Saab S, Mallam D, Cox GA 2nd, Tong MJ. Impact of coffee on liver diseases: a systematic review. Liver Int. 2014;34(4):495–504.CrossRefGoogle Scholar
  48. 48.
    Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab. 2008;33(6):1290–300.CrossRefGoogle Scholar
  49. 49.
    • Cornelis MC, Munafo MR. Mendelian randomization studies of coffee and caffeine consumption. Nutrients. 2018;10(10):1343 To establish the causality of an association, possible recent approach such as MR method will be an important step forward from epidemiological findings to elucidating the causal impact of coffee consumption. CrossRefGoogle Scholar
  50. 50.
    Cornelis MC. Toward systems epidemiology of coffee and health. Curr Opin Lipidol. 2015;26(1):20–9.CrossRefGoogle Scholar
  51. 51.
    Coffe and Caffeine Genetics Consortium, Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, et al. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry. 2015;20(5):647–56.CrossRefGoogle Scholar
  52. 52.
    Cornelis MC. The impact of caffeine and coffee on human health. Nutrients. 2019;11(2):416.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Prevention, Center for Public Health SciencesNational Cancer CenterTokyoJapan
  2. 2.Center for Public Health SciencesNational Cancer CenterTokyoJapan

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