Current Nutrition Reports

, Volume 7, Issue 3, pp 116–120 | Cite as

Use of Enteral Nutrition for Gastrointestinal Bleeding Prophylaxis in the Critically Ill: Review of Current Literature

  • Carolyn NewberryEmail author
  • Jessica Schucht
Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gastroenterology, Critical Care, and Lifestyle Medicine


Purpose of Review

This review provides a comprehensive overview of the etiology of stress-related mucosal disease, current acid suppression therapy recommendations, and the role enteral nutrition may play in disease prevention.

Recent Findings

Recent literature indicates enteral nutrition may prevent complications of stress-related mucosal disease by increasing splanchnic blood flow, enhancing gastrointestinal motility, and promoting cellular immunity and integrity through local nutrient delivery.


Stress-related mucosal disease is a common complication of hospitalization in the critically ill which may lead to overt gastrointestinal bleeding and enhanced mortality. High-risk patients have historically been prescribed acid suppression therapy, though enteral nutrition may also have a role in disease mitigation.


Enteral nutrition Stress ulcer prophylaxis Gastrointestinal bleeding Stress related mucosal disease 


Compliance with Ethical Standards

Conflict of Interest

Carolyn Newberry and Jessica Schucht declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of GastroenterologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA
  2. 2.Department of General SurgeryUniversity of LouisvilleLouisvilleUSA

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