Photodynamic Therapy and Its Use in Lung Disease

  • Jonathan S. KurmanEmail author
  • Nicholas J. Pastis
  • Septimiu D. Murgu
Interventional Pulmonology (G Cheng, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Interventional Pulmonology


Purpose of Review

Photodynamic therapy is approved in the USA for curative treatment of microinvasive endobronchial non-small cell lung cancer and palliation of symptoms with obstructing endobronchial non-small cell lung cancer. New data support its use with positive margins after surgical resection. Emerging data suggest it is both safe and efficacious for use in the periphery with non-small cell lung cancer.

Recent Findings

Several case series have demonstrated its utility with endobronchial disease from small cell lung cancer. Recent studies have examined its use with recurrent respiratory papillomatosis, adenoid cystic carcinoma, and endobronchial typical carcinoid tumor.


As further data are collected, the application of photodynamic therapy for thoracic malignancy will likely continue to expand.


Photodynamic therapy Lung cancer Carcinoid Endobronchial Recurrent respiratory papillomatosis 



Adenoid cystic carcinoma


Central airway obstruction


Carcinoma in situ


Computed tomography


Electromagnetic navigation


Human papilloma virus


Karnofsky Performance Score


Modified Medical Research Council


Non-small cell lung cancer


Overall survival


Photodynamic therapy


Quality of life


Randomized controlled trial


Recurrent respiratory papillomatosis


Small cell lung cancer


Author Contributions

Conception and design, Jonathan Kurman; administrative support, none; provision of study materials or patients, none; collection and assembly of data, none; data analysis and interpretation, all authors; manuscript writing, all authors; final approval of manuscript, all authors.

Compliance with Ethical Standards

Conflict of Interest

SDM is an educational consultant for Pinnacle Biologics. The other authors have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jonathan S. Kurman
    • 1
    Email author
  • Nicholas J. Pastis
    • 2
  • Septimiu D. Murgu
    • 3
  1. 1.Department of Medicine, Division of Pulmonary & Critical Care MedicineMedical College of WisconsinMilwaukeeUSA
  2. 2.Department of Medicine, Division of Pulmonary & Critical Care MedicineMedical University of South CarolinaCharlestonUSA
  3. 3.Department of Medicine, Division of Pulmonary & Critical Care MedicineUniversity of ChicagoChicagoUSA

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