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Photodynamic Therapy and Its Use in Lung Disease

  • Jonathan S. KurmanEmail author
  • Nicholas J. Pastis
  • Septimiu D. Murgu
Interventional Pulmonology (G Cheng, Section Editor)
  • 7 Downloads
Part of the following topical collections:
  1. Topical Collection on Interventional Pulmonology

Abstract

Purpose of Review

Photodynamic therapy is approved in the USA for curative treatment of microinvasive endobronchial non-small cell lung cancer and palliation of symptoms with obstructing endobronchial non-small cell lung cancer. New data support its use with positive margins after surgical resection. Emerging data suggest it is both safe and efficacious for use in the periphery with non-small cell lung cancer.

Recent Findings

Several case series have demonstrated its utility with endobronchial disease from small cell lung cancer. Recent studies have examined its use with recurrent respiratory papillomatosis, adenoid cystic carcinoma, and endobronchial typical carcinoid tumor.

Summary

As further data are collected, the application of photodynamic therapy for thoracic malignancy will likely continue to expand.

Keywords

Photodynamic therapy Lung cancer Carcinoid Endobronchial Recurrent respiratory papillomatosis 

Abbreviations

ACC

Adenoid cystic carcinoma

CAO

Central airway obstruction

CIS

Carcinoma in situ

CT

Computed tomography

EMN

Electromagnetic navigation

HPV

Human papilloma virus

KPS

Karnofsky Performance Score

MMRC

Modified Medical Research Council

NSCLC

Non-small cell lung cancer

OS

Overall survival

PDT

Photodynamic therapy

QoL

Quality of life

RCT

Randomized controlled trial

RRP

Recurrent respiratory papillomatosis

SCLC

Small cell lung cancer

Notes

Author Contributions

Conception and design, Jonathan Kurman; administrative support, none; provision of study materials or patients, none; collection and assembly of data, none; data analysis and interpretation, all authors; manuscript writing, all authors; final approval of manuscript, all authors.

Compliance with Ethical Standards

Conflict of Interest

SDM is an educational consultant for Pinnacle Biologics. The other authors have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jonathan S. Kurman
    • 1
    Email author
  • Nicholas J. Pastis
    • 2
  • Septimiu D. Murgu
    • 3
  1. 1.Department of Medicine, Division of Pulmonary & Critical Care MedicineMedical College of WisconsinMilwaukeeUSA
  2. 2.Department of Medicine, Division of Pulmonary & Critical Care MedicineMedical University of South CarolinaCharlestonUSA
  3. 3.Department of Medicine, Division of Pulmonary & Critical Care MedicineUniversity of ChicagoChicagoUSA

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