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Bronchoscopic Lung Volume Reduction Using Endobronchial Valves: How to Do It

  • Udit Chaddha
  • Julie Lin
  • D. Kyle HogarthEmail author
Interventional Pulmonology (G Cheng, Section Editor)
  • 6 Downloads
Part of the following topical collections:
  1. Topical Collection on Interventional Pulmonology

Abstract

Purpose of Review

Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality worldwide. Over the last decade, many studies have validated the use of endobronchial valves (EBVs) for bronchoscopic lung volume reduction (BLVR) in patients who are persistently symptomatic despite optimal medical therapy. We aimed to review the literature and describe appropriate patient selection and procedural considerations.

Recent Findings

BLVR using EBVs leads to an improvement in FEV1, 6-min walk distance, and health-related quality of life. Two valve systems have recently obtained FDA approval for use for this indication. Appropriate selection of the target lobe and assessment of fissure integrity using quantitative imaging software are essential to obtain best possible outcomes.

Summary

EBVs are a viable treatment option, with manageable complications, for patients with COPD who have hyperinflation and refractory symptoms, when there is complete fissure integrity (no collateral ventilation).

Keywords

Lung volume reduction Endobronchial valves COPD Zephyr Spiration 

Notes

Compliance with Ethical Standards

Conflict of Interest

In regard to this paper, Dr. Hogarth received an honorarium from Pulmonx for travel and training in 2018. He taught the placement of Zephyr valves at a PulmonX sponsored program at the ATS meeting in Dallas, 2019. He consulted for Spiration in the past (and received consulting fees, honoraria, but has not for over 3 years). He has consulted for Olympus (owner of Spiration) and received consulting fees for his services. He is also a consultant, on the science advisory board, and options holder for Eolo.

Dr. Chaddha and Dr. Lin have nothing to declare.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Pulmonary, Critical Care and Sleep MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Section of Pulmonary and Critical CareUniversity of Chicago MedicineChicagoUSA

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