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Current Pulmonology Reports

, Volume 7, Issue 3, pp 92–100 | Cite as

Rising to the Challenge of Unmet Need: Expanding the Lung Donor Pool

  • Aadil Ali
  • Shaf Keshavjee
  • Marcelo Cypel
Lungs Transplant (R Bag, Section Editor)
  • 1 Downloads
Part of the following topical collections:
  1. Topical Collection on Lung Transplant

Abstract

Purpose of Review

There is a shortage of lungs available to meet the needs of patient who require lung transplantation. Ex vivo lung perfusion (EVLP) has allowed for the assessment and reconditioning of extended criteria and high-risk donor lungs, allowing for an increased volume of lung transplants. Recently, an invested interest in the utilization donation after cardiac death (DCD) donors has surfaced, in which EVLP has played an important role.

Recent Findings

Clinical studies have shown that EVLP can recondition donor lungs that initially would be unacceptable for transplantation. In a recent study, the intervention of EVLP was also shown to extend the window of total organ preservation time. Preclinical studies have shown promising results for EVLP to serve as a therapeutic platform to modulate inflammation, reduce edema, and treat infections and aspiration injuries. In addition, studies have shown the potential to recondition lungs of donation after cardiac death donors which suffer from additional injury in comparison to donation after brain death donors.

Summary

EVLP is dynamic platform that can serve to treat and array of issues prior to transplantation. Indeed, the investigation of these therapeutic arsenals will soon allow physicians to expand the donor organ pool and improve transplantation outcomes.

Keywords

Ex vivo lung perfusion DCD donors Reconditioning Therapeutic platform Lung transplantation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Marcelo Cypel and Shaf Keshavjee are co-founders of Perfusix Inc. and XOR Labs Toronto (companies related to ex vivo organ perfusion) and consultants to lung bioengineering. Ali Aadil reports no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Latner Thoracic Surgery Research LaboratoriesUniversity Health NetworkTorontoCanada
  2. 2.Toronto Lung Transplant ProgramToronto General HospitalTorontoCanada

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