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Natural Products and Bioprospecting

, Volume 1, Issue 1, pp 52–56 | Cite as

Cyclopeptides from Amanita exitialis

  • Jing-Hua Xue
  • Ping Wu
  • Yu-Lang Chi
  • Liang-Xiong Xu
  • Xiao-Yi Wei
Open Access
Regular Article

Abstract

A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, α- and β-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides. Open image in new window

Keywords

Amanita Amanita exitialis cyclopeptides amanexitide 

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Copyright information

© The Author(s) 2011

This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Jing-Hua Xue
    • 1
  • Ping Wu
    • 1
  • Yu-Lang Chi
    • 1
  • Liang-Xiong Xu
    • 1
  • Xiao-Yi Wei
    • 1
  1. 1.Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical GardenChinese Academy of SciencesGuangzhouChina

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