Natural Products and Bioprospecting

, Volume 1, Issue 1, pp 52–56 | Cite as

Cyclopeptides from Amanita exitialis

  • Jing-Hua Xue
  • Ping Wu
  • Yu-Lang Chi
  • Liang-Xiong Xu
  • Xiao-Yi Wei
Open Access
Regular Article


A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, α- and β-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides. Open image in new window


Amanita Amanita exitialis cyclopeptides amanexitide 


  1. [1]
    Li, C.; Oberlies, N. H. Life Sci.2005, 78, 532–538.PubMedCrossRefGoogle Scholar
  2. [2]
    Letschert, K.; Heinz Faulstich, H.; Keller, D.; Keppler, D. Toxicol. Sci.2006, 91, 140–149.PubMedCrossRefGoogle Scholar
  3. [3]
    Wieland, T.; Faulstich, H. Crit. Rev. Biochem. Mol.1978, 5, 185–260.CrossRefGoogle Scholar
  4. [4]
    Kroncke, K. D.; Fricker, G.; Meier, P. J.; Gerokn, W.; Wieland, T.; Kurz, G. J. Biol. Chem.1986, 261, 12562–12567.PubMedGoogle Scholar
  5. [5]
    Yang, Z. L.; Li, T. H. Mycotaxon2001, 78, 439–448.Google Scholar
  6. [6]
    Zhang, P.; Chen, Z. H.; Hu, J. S.; Wei, B. Y.; Zhang, Z. G.; Hu, W. Q. FEMS Microbiol. Lett.2005, 252, 223–228.PubMedCrossRefGoogle Scholar
  7. [7]
    Hu, J. S.; Chen, Z. H.; Zhang, Z. G.; Zhang, P. Acta Microbiol. Sin.2003, 43, 642–646.Google Scholar
  8. [8]
    Chi, Y. L.; Zhang, H. Y.; Xue, J. H.; Hao, J.; Liu, M. F.; Wei X. Y. Chin. Chem. Lett.2009, 20, 830–832.CrossRefGoogle Scholar
  9. [9]
    Kim, K. H.; Choi, S. U.; Park, K. M.; Seok, S. J.; Lee, K. R. Arch. Pharm. Res.2008, 31, 579–586.PubMedCrossRefGoogle Scholar
  10. [10]
    Zhou, J.; Tan, N. H. Chin. Sci. Bull.2000, 45, 1825–1831.CrossRefGoogle Scholar
  11. [11]
    Wélé, A.; Landon, C.; Labbé, H.; Vovelle, F.; Zhang, Y.; Bodo, B. Tetrahedron2004, 60, 405–414.CrossRefGoogle Scholar
  12. [12]
    Tomer, K. B.; Crow, F. W.; Gross, M. L. Anal. Chem.1984, 56, 880–886.PubMedCrossRefGoogle Scholar
  13. [13]
    Li, X. H.; Xu, L. X.; Wu, P.; Xie, H. H.; Huang, Z. L.; Ye, W. H.; Wei, X. Y. Chem. Pharm. Bull.2009, 57, 495–498.PubMedCrossRefGoogle Scholar
  14. [14]
    Yang, Y. L.; Hua, K. F.; Chuang, P. H.; Wu, S. H.; Wu, K. Y.; Chang, F. R.; Wu, Y. C. J. Agric. Food Chem.2008, 56, 386–392.PubMedCrossRefGoogle Scholar
  15. [15]
    Ngoka, L. C. M.; Gross, M. L. J. Am. Soc. Mass Spectrom.1999, 10, 360–363.PubMedCrossRefGoogle Scholar

Copyright information

© The Author(s) 2011

This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Jing-Hua Xue
    • 1
  • Ping Wu
    • 1
  • Yu-Lang Chi
    • 1
  • Liang-Xiong Xu
    • 1
  • Xiao-Yi Wei
    • 1
  1. 1.Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical GardenChinese Academy of SciencesGuangzhouChina

Personalised recommendations