Oriental Pharmacy and Experimental Medicine

, Volume 18, Issue 3, pp 177–186 | Cite as

The role of medicinal plants and natural products in melioration of cadmium toxicity

  • Sanjib BhattacharyaEmail author


Cadmium is extremely toxic heavy metal and there is no specific, safe and efficacious therapeutic management of cadmium toxicity. Scientific literature reveals several medicinal plants and natural products alleviate experimentally induced cadmium toxicity in animals. The present review attempts to collate those experimental studies on medicinal plants and plant derived natural products with cadmium toxicity ameliorative effects. Literature survey was carried out by using internet and the studies for the last two decades were considered. Minerals and semi-synthetic or synthetic analogs of natural products were excluded. Literature study revealed that 36 medicinal plants and 16 natural products exhibited significant protection from cadmium toxicity in experimental animal models i.e., pre-clinical studies. Clinical studies were not found in literature. Relevant research in this field could lead to development of a potentially useful agent in therapeutic management of cadmium toxicity in humans.


Cadmium Ascorbic acid Natural products Oxidative stress Quercetin 


Compliance with ethical standards

Ethical statement


Conflict of interest

This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors.


  1. Abu-Taweel GM (2016) Effects of curcumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetylcholinesterase in cadmium intoxicated mice. Saudi J Biol Sci 23:219–228PubMedCrossRefGoogle Scholar
  2. Acharya UR, Mishra M, Patro J, Panda MK (2008) Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium. Reprod Toxicol 25:84–88PubMedCrossRefGoogle Scholar
  3. Adaramoye OA, Akanni OO (2016) Modulatory effects of methanol extract of Artocarpus altilis (Moraceae) on cadmium-induced hepatic and renal toxicity in male Wistar rats. Pathophysiology 23:1–9PubMedCrossRefGoogle Scholar
  4. Adikwu E, Deo O, Geoffrey OP (2013) Hepatotoxicity of cadmium and roles of mitigating agents. Br J Pharmacol Toxicol 4:222–231CrossRefGoogle Scholar
  5. Ali MM, Shukla GS, Srivastava RS, Mathur N, Chandra SV (1993) Effects of vitamin E on cadmium-induced locomotor dysfunctions in rats. Vet Hum Toxicol 35:109–111PubMedGoogle Scholar
  6. Alkhedaide A, Alshehri ZS, Sabry A, Abdel-Ghaffar T, Soliman MM, Attia H (2016) Protective effect of grape seed extract against cadmium-induced testicular dysfunction. Mol Med Rep 13:3101–3109PubMedPubMedCentralCrossRefGoogle Scholar
  7. Al-Olayan EM, El-Khadragy MF, Aref AM, Othman MS, Kassab RB, Abdel Moneim AE (2014) The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression. Oxid Med Cell Longev 14:381413Google Scholar
  8. Amamou F, Nemmiche S, Meziane RK, Didi A, Yazit SM, Chabane-Sari D (2015) Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats. Food Chem Toxicol 78:177–184PubMedCrossRefGoogle Scholar
  9. Argüelles-Velázquez N, Madrigal-Bujaidar E, Alvarez-González I, Chamorro-Cevallos G (2013) Amelioration of cadmium-produced teratogenicity and genotoxicity in mice given Arthrospira maxima (Spirulina) treatment. Evid Based Complement Altern Med. Article ID: 604535.
  10. Aslam M, Ahmad ST, Dayal R, Javid K, Umar S, Asiaf A, Nafees S, Bhat JU, Wani A, Samim M, Singh S (2012) Nephroprotective action of Peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats. EXCLI J 11:444–452PubMedPubMedCentralGoogle Scholar
  11. Baiomy AA (2016) Protective role of grape seeds extract against cadmium toxicity in the lung of male Wistar rats. J Cytol Histol S 5:004Google Scholar
  12. Bernard A (2008) Cadmium & its adverse effects on human health. Indian J Med Res 128:557–564PubMedGoogle Scholar
  13. Bernhoft RA (2013) Cadmium toxicity and treatment. Sci World. Article ID 394652Google Scholar
  14. Bharavi K, Reddy AG, Rao GS, Reddy AR, Rao SVR (2010) Reversal of cadmium-induced oxidative stress in chicken by herbal adaptogens Withania somnifera and Ocimum sanctum. Toxicol Int 17:59–63PubMedPubMedCentralCrossRefGoogle Scholar
  15. Bhattacharya S (2017) Medicinal plants and natural products in amelioration of arsenic toxicity: a short review. Pharm Biol 55:349–354PubMedCrossRefGoogle Scholar
  16. Bhattacharya S, Haldar PK (2012a) Trichosanthes dioica root possesses stimulant laxative activity in mice. Nat Prod Res 26:952–957PubMedCrossRefGoogle Scholar
  17. Bhattacharya S, Haldar PK (2012b) Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents. Nat Prod Res 26:2348–2352PubMedCrossRefGoogle Scholar
  18. Biswas M, Bhattacharya S, Mukhopadhyay R, Haldar PK (2018) Dregea volubilis (L. f.) Benth. (Asclepiadaceae): an appraisal on pharmacognostic, phytochemical and pharmacological studies. Orient Pharm Exp Med 18:1–8CrossRefGoogle Scholar
  19. Blanusa M, Varnai VM, Piasek M, Kostial K (2005) Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem 12:2771–2794PubMedCrossRefGoogle Scholar
  20. Borde AU, Athawaley AM, Mendhe MS, Patil MK, Lokhande PR, Jaiswal SA (2008) Ameliorating potential of Ashwagandha on cadmium chloride induced changes in weights of visceral organs. Vet World 1:343–345Google Scholar
  21. Chatterjee PK, Vinodini NA, Singh R, Rakshatha R, Amemarsoofi A, Pai SR (2013) Effect of Moringa oleifera leaf extract on cadmium induced renal toxicity in adult Wistar Albino rats. Int J Adv Res 1:162–165Google Scholar
  22. Chopra M, Sharma A, Sharma VL (2013) Amelioration of cadmium induced nephrotoxicity in Balb/c mice by Withania sominifera and vitamin E. Int J Nat Prod Sci 3:9–19Google Scholar
  23. Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ, Nawrot T, Vangronsveld J, Smeets K (2010) Cadmium stress: an oxidative challenge. Biometals 23:927–940PubMedCrossRefGoogle Scholar
  24. Das SK, Bhattacharya S, Kundu A (2013) Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyindole analogs through environment friendly reaction. J Adv Pharm Technol Res 4:198–205PubMedPubMedCentralCrossRefGoogle Scholar
  25. Das A, Roy A, Das R, Bhattacharya S, Haldar PK (2016) Naringenin alleviates cadmium-induced toxicity through the abrogation of oxidative stress in Swiss albino mice. J Environ Pathol Toxicol Oncol 35:161–169PubMedCrossRefGoogle Scholar
  26. Dkhil MA, Al-Quraishy S, Diab MM, Othman MS, Aref AM, Abdel Moneim AE (2014) The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity. Food Chem Toxicol 74:98–106PubMedCrossRefGoogle Scholar
  27. Donpunha W, Kukongviriyapan U, Sompamit K, Pakdeechote P, Kukongviriyapan V, Pannangpetch P (2011) Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice. Biometals 24:105–115PubMedCrossRefGoogle Scholar
  28. Dua TK, Dewanjee S, Khanra R, Bhattacharya N, Bhaskar B, Zia-Ul-Haq M, De Feo V (2015) The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism. J Transl Med 13:245PubMedPubMedCentralCrossRefGoogle Scholar
  29. El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH (2004) Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene. Food Chem Toxicol 42:1563–1571PubMedCrossRefGoogle Scholar
  30. Eleawa SM, Alkhateeb MA, Alhashem FH, Bin-Jaliah I, Sakr HF, Elrefaey HM, Elkarib AO, Alessa RM, Haidara MA, Shatoor AS, Khalil MA (2014) Resveratrol reverses cadmium chloride-induced testicular damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression. J Reprod Dev 60:115–127PubMedPubMedCentralCrossRefGoogle Scholar
  31. Elgaml SA, Hashish EA (2014) Clinicopathological studies of Thymus vulgaris extract against cadmium induced hepatotoxicity in albino rats. Glob J Pharmacol 8:501–509Google Scholar
  32. El-Missiry MA, Shalaby F (2000) Role of beta-carotene in ameliorating the cadmium-induced oxidative stress in rat brain and testis. J Biochem Mol Toxicol 14:238–243PubMedCrossRefGoogle Scholar
  33. El-Morsy AM, Sakr SA, Bayomy MF (2015) Ameliorative effect of aqueous leaves extract of Rosemarinus officinalis on cadmium—induced kidney injury in albino rats. J Biosci Appl Res 1:10–19Google Scholar
  34. El-Sayed YS, El-Gazzar AM, El-Nahas AF, Ashry KM (2016) Vitamin C modulates cadmium-induced hepatic antioxidants’ gene transcripts and toxicopathic changes in Nile tilapia, Oreochromis niloticus. Environ Sci Pollut Res Int 23:1664–1670PubMedCrossRefGoogle Scholar
  35. Eybl V, Kotyzova D, Koutensky J (2006) Comparative study of natural antioxidants—curcumin, resveratrol and melatonin—in cadmium-induced oxidative damage in mice. Toxicology 225:150–156PubMedCrossRefGoogle Scholar
  36. Flora SJS, Pachauri V (2010) Chelation in metal intoxication. Int J Environ Res Public Health 7:2745–2788PubMedPubMedCentralCrossRefGoogle Scholar
  37. Flora SJS, Mittal M, Mehta A (2008) Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 128:501–523PubMedGoogle Scholar
  38. Gaurav D, Preet S, Dua KK (2010) Protective effect of Spirulina platensis on cadmium induced renal toxicity in Wistar rats. Arch Appl Sci Res 2:390–397Google Scholar
  39. Gong P, Chen F, Wang J, Jin S, Ma Y (2014) The ameliorate effect of anthocyanin on mouse testis damage. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 32(10):762–764PubMedGoogle Scholar
  40. Greń A, Barbasz A, Kreczmer B, Sieprawska A, Rudolphi-Skórska E, Filek M (2012) Protective effect of ascorbic acid after single and repetitive administration of cadmium in Swiss mice. Toxicol Mech Methods 22:597–604PubMedCrossRefGoogle Scholar
  41. Gupta RS, Kim J, Gomes C, Oh S, Park J, Im WB, Seong JY, Ahn RS, Kwon HB, Soh J (2004) Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Mol Cell Endocrinol 221:57–66PubMedCrossRefGoogle Scholar
  42. Hassanin KMA, Safwat GM (2014) Role of Nigella Sativa oil in alleviating increased reproductive hormones and some inflammatory mediators caused by cadmium toxicity in rat testes. Int J Adv Res 2:606–611Google Scholar
  43. Imafidon CE, Akomolafe RO, Abubakar SA, Ogundipe OJ, Olukiran OS, Ayowole OA (2015) Amelioration of cadmium-induced nephropathy using polyphenol-rich extract of Vernonia amygdalina (Del.) leaves in rat model. Open Access Macedonian J Med Sci 3:567–577CrossRefGoogle Scholar
  44. Inegbedion A, Eriyamremu GE, Gilbert U, Okoro IO (2016) Lipid peroxidation level and antioxidant enzyme activities in the liver and kidney of rabbits exposed to cadmium and aqueous leaf extract of Bryophyllum pinnatum. Point J Med Med Res 2:108–111Google Scholar
  45. Izaguirry AP, Soares MB, Vargas LM, Spiazzi CC, Dos Santos BD, Noremberg S, Mendez AS, Santos FW (2017) Blueberry (Vaccinium ashei Reade) extract ameliorates ovarian damage induced by subchronic cadmium exposure in mice: potential δ-ALA-D involvement. Environ Toxicol 32:188–196PubMedCrossRefGoogle Scholar
  46. Jaishankar M, Tseten T, Anbalagan N, Mathew MM, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7:60–72PubMedPubMedCentralCrossRefGoogle Scholar
  47. Jeyaprakash K, Chinnaswamy P (2005) Effect of Spirulina and Liv. 52 on cadmium induced toxicity in albino rats. Indian J Exp Biol 43:773–781PubMedGoogle Scholar
  48. Ji YL, Wang Z, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX (2012) Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes. Reprod Toxicol 34:357–363PubMedCrossRefGoogle Scholar
  49. John NAA, Shobana G, Keerthana K (2014) Protective effect of Coriander sativum L. on cadmium induced toxicity in albino rats. World J Pharm Pharm Sci 3:525–534Google Scholar
  50. Kandelwal S, Shukla LJ, Shanker R (2002) Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat. Indian J Exp Biol 40:564–570Google Scholar
  51. Kanter M, Aktoz T, Aktas C, Ozen F, Yarali O, Kanter B (2016) Role of Quercetin in cadmium-induced oxidative stress, testicular damage, and apoptosis in rats. Anal Quant Cytopathol Histpathol 38:45–51PubMedGoogle Scholar
  52. Kaoud HA, Zaki MM, El-Dahshan AR, Saeid S, El Zorba HY (2011) Amelioration the toxic effects of cadmium-exposure in Nile Tilapia (Oreochromis Niloticus) by using Lemna gibba L. Life Sci J 8:185–195Google Scholar
  53. Khorasgani EM, Pirbalouti AG, Adibi S (2015) Histopathological evidences for effect beneficial of Satureja hortensis extract on hepatic lesion by cadmium–induced in rat. J Herbal Drugs 6:101–108Google Scholar
  54. Koriem KMM, Farrag ARH, Badawy MA, El-Toumy SA (2009) Role of some Egyptian medicinal plants against liver and kidney toxicity induced by cadmium chloride. Toxicol Mech Methods 19:524–534PubMedCrossRefGoogle Scholar
  55. Kowalczyk E, Kopff A, Fijałkowski P, Kopff M, Niedworok J, Błaszczyk J, Kedziora J, Tyślerowicz P (2003) Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium. Acta Biochim Pol 50(2):543–548PubMedGoogle Scholar
  56. Kukongviriyapan U, Pannangpetch P, Kukongviriyapan V, Donpunha W, Sompamit K, Surawattanawan P (2014) Curcumin protects against cadmium-induced vascular dysfunction, hypertension and tissue cadmium accumulation in mice. Nutrients 6:1194–1208PubMedPubMedCentralCrossRefGoogle Scholar
  57. Leelavinothan P, Kalist S (2011) Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study. Eur Rev Med Pharmacol Sci 15:992–1002PubMedGoogle Scholar
  58. Logeswari P, Dineshkumar V, Usha PTA, Kumar SMP (2012) Proximate analysis of Sida rhombifolia L root and its effect on cadmium chloride induced alterations in body weight of Wistar rats. Int J Pharm Biol Sci 2:303–309Google Scholar
  59. Mitra E, Basu A, Ghosh D, Ghosh AK, Chattopadhyay A, Pattari SK, Datta S, Bandyopadhyay D (2013) Ameliorative effect of aqueous tulsi leaf (Ocimum sanctum) extract against cadmium-induced oxidative stress in rat liver. Int J Pharm Pharm Sci 5:557–568Google Scholar
  60. Moneim AEA, Bauomy AA, Diab MM, Shata MT, Al-Olayan EM, El-Khadragy MF (2014) The protective effect of Physalis peruviana L. against cadmium-induced neurotoxicity in rats. Biol Trace Elem Res 160:392–399PubMedCrossRefGoogle Scholar
  61. Muhammed ZI (2014) Effect of phenolic compound extract of green tea to amelioratethe Cadmium Sulphate toxicity on the female rat kidneys. IOSR J Pharm Biol Sci 9:44–50Google Scholar
  62. Murugavel P, Pari L (2007a) Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats. Hum Exp Toxicol 26:527–534PubMedCrossRefGoogle Scholar
  63. Murugavel P, Pari L (2007b) Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. J Basic Clin Physiol Pharmacol 18:37–48PubMedCrossRefGoogle Scholar
  64. Nemmiche S, Chabane-Sari D, Guiraud P (2007) Role of alpha-tocopherol in cadmium-induced oxidative stress in Wistar rat’s blood, liver and brain. Chem Biol Interact 170:221–230PubMedCrossRefGoogle Scholar
  65. Nordberg G (1999) Excursions of intake above ADI: case study on cadmium. Regul Toxicol Pharmacol 30:S57–S62PubMedCrossRefGoogle Scholar
  66. Nordberg GF, Nogawa K, Nordberg M, Friberg L (2007) Cadmium. In: Nordberg GF, Fowler BF, Nordberg M, Friberg L (eds) Handbook of the toxicology of metals, 3rd edn. Elsevier, Amsterdam, p 479Google Scholar
  67. Obioha UE, Suru SM, Ola-Mudathir KF, Faremi TY (2009) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats. Biol Trace Elem Res 129:143–156PubMedCrossRefGoogle Scholar
  68. Ognjanović BI, Pavlović SZ, Maletić SD, Zikić RV, Stajn AS, Radojicić RM, Saicić ZS, Petrović VM (2003) Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol Res 52:563–570PubMedGoogle Scholar
  69. Oguzturk H, Ciftci O, Aydin M, Timurkaan N, Beytur A, Yilmaz F (2012) Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats. Andrologia 44:243–249PubMedCrossRefGoogle Scholar
  70. Ojo OA, Ajiboye BO, Oyinloye BE, Ojo AB (2014a) Haematological properties of Irvingia gabonensis in male adult rats. J Pharm Sci Innov 3:434–436CrossRefGoogle Scholar
  71. Ojo OA, Ajiboye BO, Oyinloye BE, Ojo AB, Olarewaju OI (2014b) Protective effect of Irvingia gabonensis stem bark extract on cadmium-induced nephrotoxicity in rats. Interdiscip Toxicol 7:208–214PubMedCrossRefGoogle Scholar
  72. Ojo OA, Ajiboye BO, Oyinloye BE, Ojo AB (2014) Prophylactic effects of ethanolic extract of Irvingia gabonensis stem bark against cadmium-Induced toxicity in albino rats. Adv Pharm. Article ID 894610.
  73. Olalekan Lawal A, Lawal AF, Ologundudu A, Adeniran OY, Omonkhua A, Obi F (2011) Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid. J Toxicol Sci 36:549–557PubMedCrossRefGoogle Scholar
  74. Ola-Mudathir FK, Suru SM (2015) Onion and garlic extracts as potential antidotes for cadmium-induced biochemical alterations in prostate glands of rats. Andrologia 47:1075–1082PubMedCrossRefGoogle Scholar
  75. Ola-Mudathir KF, Suru SM, Fafunso MA, Obioha UE, Faremi TY (2008) Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Food Chem Toxicol 46:3604–3611PubMedCrossRefGoogle Scholar
  76. Olubunmi OP, Yinka OS, Oladele OJ, Olubusayo FA, Afees OJ (2016) An assessment of renal function parameters on the ameliorative roperties of Ginkgo biloba extract in cadmium-induced nephrotoxicity in adult Wistar rats model. Am J Clin Exp Med 4:112–117CrossRefGoogle Scholar
  77. Onoshe S, Madusolumuo MA (2014) Effect of hexane seed extract of Nigella sativa on cadmium induced renal dysfunction in rats. Am J Res Commun 2:158–171Google Scholar
  78. Othman MS, Nada A, Zaki HS, Abdel Moneim AE (2014) Effect of Physalis peruviana L. on cadmium-induced testicular toxicity in rats. Biol Trace Elem Res 159:278–287PubMedCrossRefGoogle Scholar
  79. Oyinloye BE, Adenowo AF, Osunsanmi FO, Ogunyinka BI, Nwozo SO, Kappo AP (2016a) Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats. SpringerPlus 5:641PubMedPubMedCentralCrossRefGoogle Scholar
  80. Oyinloye BE, Ajiboye BO, Ojo OA, Musa HM, Onikanni SA, Ojo AA (2016b) Ameliorative potential of Aframomum melegueta extract in cadmium- induced hepatic damage and oxidative stress in male Wistar rats. J Appl Pharm Sci 6:94–99CrossRefGoogle Scholar
  81. Oyinloye BE, Ajiboye BO, Ojo OA, Nwozo SO, Kappo AP (2016c) Cardioprotective and antioxidant influence of aqueous extracts from Sesamum indicum seeds on oxidative stress induced by cadmium in wistar rats. Phcog Mag 12(S2):170–174Google Scholar
  82. Pal S, Pal PB, Das J, Sil PC (2011) Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. Toxicol 283:129–139CrossRefGoogle Scholar
  83. Pari L, Murugavel P (2007) Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology 234:44–50PubMedCrossRefGoogle Scholar
  84. Pari L, Shagirtha K (2012) Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats. Exp Toxicol Pathol 64:513–520PubMedCrossRefGoogle Scholar
  85. Pari L, Murugavel P, Sitasawad SL, Kumar KS (2007) Cytoprotective and antioxidant role of diallyl tetrasulfide on cadmium induced renal injury: an in vivo and in vitro study. Life Sci 80:650–658PubMedCrossRefGoogle Scholar
  86. Pathak N, Khandelwal S (2006) Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and blastogenesis. Biochem Pharmacol 72:486–497PubMedCrossRefGoogle Scholar
  87. Patra RC, Rautray AK, Swarup D (2011) Oxidative stress in lead and cadmium toxicity and its mmelioration. Vet Med Int. Article ID 457327Google Scholar
  88. Ponnusamy M, Pari L (2011) Protective role of diallyl tetrasulfide on cadmium-induced testicular damage in adult rats: a biochemical and histological study. Toxicol Ind Health 27:407–416PubMedCrossRefGoogle Scholar
  89. Prabu SM, Shagirtha K, Renugadevi J (2010a) Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. Eur Rev Med Pharmacol Sci 14:903–914Google Scholar
  90. Prabu SM, Shagirtha K, Renugadevi J (2010b) Amelioration of cadmium-induced oxidative stress, impairment in lipids and plasma lipoproteins by the combined treatment with quercetin and α-tocopherol in rats. J Food Sci 75:T132–T140PubMedCrossRefGoogle Scholar
  91. Prabu SM, Shagirtha K, Renugadevi J (2011) Naringenin in combination with vitamins C and E potentially protects oxidative stress-mediated hepatic injury in cadmium-intoxicated rats. J Nutr Sci Vitaminol (Tokyo) 57:177–185CrossRefGoogle Scholar
  92. Purohit RK, Purkharam BS, Isran R, Agarwal M, Chakrawarti A (2015) Radiation and cadmium induced testicular injury and its amelioration by Aloe vera extract. Int J Pharm Bio Sci 6:821–829Google Scholar
  93. Rahimzadeh MR, Rahimzadeh MR, Kazemi S, Moghadamnia AA (2017) Cadmium toxicity and treatment: an update Caspian. J Intern Med 8:135–145Google Scholar
  94. Rajendar B, Bharavi K, Rao GS, Kishore PV, Kumar PR, Kumar CS, Kumar DS (2011a) Protective effect of alpha-tocopheral on biochemical and histological alterations induced by cadmium in rat testes. Indian J Physiol Pharmacol 55:213–220PubMedGoogle Scholar
  95. Rajendar B, Bharavi K, Rao GS, Kishore PV, Kumar PR, Kumar CS, Patel TP (2011b) Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage. Indian J Pharmacol 43:568–573PubMedPubMedCentralCrossRefGoogle Scholar
  96. Ray SD, Wong V, Rinkovsky A, Bagchi M, Raje RR, Bagchi D (2000) Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice. Res Commun Mol Pathol Pharmacol 107:105–128PubMedGoogle Scholar
  97. Renugadevi J, Prabu SM (2009) Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology 256:128–134PubMedCrossRefGoogle Scholar
  98. Renugadevi J, Prabu SM (2010a) Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol 62:171–181PubMedCrossRefGoogle Scholar
  99. Renugadevi J, Prabu SM (2010b) Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol 62:471–481PubMedCrossRefGoogle Scholar
  100. Roopha PD, Padmalatha C (2012) Effect of herbal preparation on heavy metal (cadmium) induced antioxidant system in female Wistar rats. J Med Toxicol 8:101–107CrossRefGoogle Scholar
  101. Sakr SA, Bayomy MF, El-Morsy AM (2015) Rosemary extract ameliorates cadmium-induced histological changes and oxidative damage in the liver of albino rat. J Basic Appl Zool 71:1–9CrossRefGoogle Scholar
  102. Satarug S, Garrett SH, Sens MA, Sens DA (2011) Cadmium, environmental exposure, and health outcomes. Ciência Saúde Coletiva 16:2587–2602PubMedPubMedCentralCrossRefGoogle Scholar
  103. Shagirtha K, Pari L (2011) Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats. Ecotoxicol Environ Saf 74:2105–2111PubMedCrossRefGoogle Scholar
  104. Shagirtha K, Muthumani M, Prabu SM (2011) Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. Eur Rev Med Pharm Sci 15:1039–1050Google Scholar
  105. Singh KP, Bhattacharya S, Sharma P (2014) Assessment of heavy metal contents of some Indian medicinal plants. Am Eurasian J Agric Environ Sci 14:1125–1129Google Scholar
  106. Spiazzi CC, Manfredini V, Barcellos da Silva FE, Flores EM, Izaguirry AP, Vargas LM, Soares MB, Santos FW (2013) γ-Oryzanol protects against acute cadmium-induced oxidative damage in mice testes. Food Chem Toxicol 55:526–532PubMedCrossRefGoogle Scholar
  107. Tandon SK, Singh S, Prasad S, Khandekar K, Dwivedi VK, Chatterjee M, Mathur N (2003) Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett 145:211–217PubMedCrossRefGoogle Scholar
  108. Tarasub N, Junseecha T, Tarasub C, Na Ayutthaya WD (2012) Protective effects of curcumin, vitamin C, or their combination on cadmium-induced hepatotoxicity. J Basic Clin Pharm 3:273–281PubMedPubMedCentralCrossRefGoogle Scholar
  109. Thiruchelvi R, Arul D, Meenakshi S, Subramanian K (2012) Protective effects of Terminalia chebula fruit extract against cadmium-induced nephrotoxicity in rats. Int J Environ Biol 2:108–112Google Scholar
  110. Vinodini NA, Chatterjee PK, Amemarsoofi A, Suman VB, Pai SR (2014) Evaluation of liver functions with Moringa oleifera leaf extract in cadmium induced adult Wistar albino rats. Int J Plant Anim Environ Sci 4:103–106Google Scholar
  111. Wang J, Ren T, Wang F, Han Y, Liao M, Jiang Z, Liu H (2016) Effects of dietary cadmium on growth, antioxidants and bioaccumulation of sea cucumber (Apostichopus japonicus) and influence of dietary vitamin C supplementation. Ecotoxicol Environ Saf 129:145–153PubMedCrossRefGoogle Scholar
  112. Warren S, Patel S, Kapron CM (2000) The effect of vitamin E exposure on cadmium toxicity in mouse embryo cells in vitro. Toxicology 142:119–126PubMedCrossRefGoogle Scholar
  113. Yang HS, Han DK, Kim JR, Sim JC (2006) Effects of alpha-tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis. J Korean Med Sci 21:445–451PubMedPubMedCentralCrossRefGoogle Scholar
  114. Zargar S, Siddiqi NJ, Al Daihan SK, Wani TA (2015) Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver. Acta Biochim Pol 62:207–213PubMedCrossRefGoogle Scholar
  115. Zhai Q, Narbad A, Chen W (2015) Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients 7:552–571PubMedCrossRefGoogle Scholar

Copyright information

© Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.West Bengal Medical Services Corporation Ltd.Salt Lake City, KolkataIndia

Personalised recommendations