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Journal of Radiation Oncology

, Volume 8, Issue 1, pp 97–101 | Cite as

Reconstructed and real proton radiographs for image-guidance in proton beam therapy

  • Chelsea Miller
  • Basel Altoos
  • Ethan A. DeJongh
  • Mark Pankuch
  • Don F. DeJongh
  • Victor Rykalin
  • Caesar E. Ordoñez
  • Nicholas T. Karonis
  • John R. Winans
  • George Coutrakon
  • James S. WelshEmail author
Rapid Communication
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Abstract

One of the major challenges to proton beam therapy at this time is the uncertainty of the true range of a clinical treatment proton beam as it traverses the various tissues and organs in a human body. This uncertainty necessitates the addition of greater “margins” to the planning target volume along the direction of the beam to ensure safety and tumor target coverage.

Proton radiography holds promise as both an image-guidance method for proton beam therapy and as a means of estimating particle beam range in the clinic. In this brief report, we present some of the first real and reconstructed proton radiographs using our particular system. Our qualitative review of these images indicates that this method has excellent potential as a proton radiography–based image-guidance system. Based on the encouraging results of our preliminary work, more rigorous and quantitative analyses will be performed shortly and we shall continue to explore the potential of this approach for addressing the particle beam range uncertainty issue.

Keywords

Proton radiography Proton CT Particle beam therapy Range uncertainty Proton Image-Guidance 

Notes

Compliance with ethical standards

Funding

This study was funded in part by The National Cancer Institute of the National Institutes of Health contract number R44CA203499, the US Department of the Army contract number W81XWH-10-1-0170, and the US Department of Energy contract number DE-SC0005135 sponsored this work. The US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD, 21702–5014, is the awarding and administering acquisition office for contract number W81XWH-10-1-0170. The content in this article does not necessarily reflect the position or policy of the Government, and no official endorsement should be inferred.

Conflict of Interest

Don F. DeJongh and Victor Rykalin are co-founders of ProtonVDA, Inc., Naperville, IL, 60563, USA, and Ethan A. DeJongh is an employee of ProtonVDA, Inc. None of the other authors have relevant potential conflicts of interest. James Welsh has served in the past as an advisor to ProTom International.

Human and animal studies statement

This article does not describe any work done with living animals.

Informed consent

All patients from which the CT data was obtained provided informed consent for use of their anonymized images for this study.

References

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    M Y, Zhu XR, Park PC, Titt U, Mohan R, Virshup G, Clayton JE, Dong L (2012) Comprehensive analysis of proton range uncertainties related to patient stopping-power-ratio estimation using the stoichiometric calibration. Phys Med Biol 57:4095CrossRefGoogle Scholar
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    Welsh JS, DeJongh F, Rykalin V, Karonis N, Ordonez C, Winans J, Coutrakon G, DeJongh E, Pankuch M (2017) The use of established methods to quantify proton range uncertainty reduction when using proton tomography. Int J Radiat OncolBiolPhys 99(2):E737Google Scholar
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    Welsh J, Pankuch M, Coutrakon G, Rykalin V, DeJongh E, Karonis N, Ordonez C, Winans J, Polnyi I, DeJongh F (2017) Radiation dose and risks of radiation carcinogenesis from proton radiography vs X-ray based methods of range determination and image guidance. PTC17-0522: Additional Proceedings. Int J Particle Ther: Fall 4(2):39–231Google Scholar
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    Welsh JS, DeJongh F, Rykalin V, Karonis N, DeJongh E, Coutrakon G, Ordonez C, Winans J, Pankuch M (2017) Image reconstruction with a fast, monolithic proton radiography system. Int J Radiat Oncol Biol Phys 99(2):E737–E738Google Scholar

Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • Chelsea Miller
    • 1
  • Basel Altoos
    • 1
  • Ethan A. DeJongh
    • 2
  • Mark Pankuch
    • 3
  • Don F. DeJongh
    • 2
  • Victor Rykalin
    • 2
  • Caesar E. Ordoñez
    • 4
  • Nicholas T. Karonis
    • 5
    • 6
  • John R. Winans
    • 4
  • George Coutrakon
    • 7
  • James S. Welsh
    • 1
    • 8
    Email author
  1. 1.Department of Radiation OncologyLoyola University Stritch School of MedicineMaywoodUSA
  2. 2.Proton VDA, Inc.NapervilleUSA
  3. 3.Northwestern Medicine Chicago Proton CenterWarrenvilleUSA
  4. 4.Center for Research Computing and DataNorthern Illinois UniversityDeKalbUSA
  5. 5.Computer Science DepartmentNorthern Illinois UniversityDeKalbUSA
  6. 6.Argonne National Laboratory, Data Science and Learning DivisionArgonneUSA
  7. 7.Physics DepartmentNorthern Illinois UniversityDeKalbUSA
  8. 8.Radiation Oncology ServiceEdward Hines VA HospitalHinesUSA

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