Structure and regulatory networks of WD40 protein in plants
Plants have been gifted with intricate regulatory networks to carry on with their sessile life form. Often such networks involve delicate association between various proteins. The WD40 proteins, which are present abundantly in several eukaryotes, act as scaffolding molecules assisting proper activity of other proteins. They comprise several stretches of 44–60 amino acid residues and often terminate with a WD dipeptide. They function in several cellular, metabolic and molecular pathways, biologically playing important roles in plant development and also during stress signaling. Moreover, some WD40 (named DWD) proteins also function as substrate receptors in Cullin4 RING dependent E3 ubiquitin ligase mediated proteosomal degradation and DNA damage repair mechanism. In this review, we have discussed the various aspects of these proteins that affect their highly diversified functions in plants.
KeywordsWD40 protein DWD box β-propeller Scaffold CLR4 ligase
Domain invasion motif
Tightly associated factors
DNA Damaged Binding1
Embryonic Ectoderm Development
Grateful thanks are due to the Director, National Institute of Plant Genome Research (NIPGR), New Delhi, India for providing facilities. The authors work in this area was supported by NIPGR core grant and Department of Biotechnology (DBT), Govt. of India. Mr Awdhesh Kumar Mishra and Ms Swati Puranik acknowledge the fellowships form the Council of Scientific and Industrial Research, and NIPGR, New Delhi, respectively.
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