Réanimation

, Volume 22, Supplement 2, pp 352–358 | Cite as

Mitochondria — key roles in sepsis

Enseignement Supérieur en Réanimation Fondamental
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Résumé

Au cours du sepsis, les mécanismes physiopathologiques sous-tendant le développement et la récupération des dysfonctions d’organe sont encore mal compris. La dysfonction mitochondriale pourrait jouer un rôle majeur. Cette mise au point décrit la physiologie normale des mitochondries, les arguments reliant l’altération bioénergétique mitochondriale aux dysfonctions d’organes après des périodes d’inflammation sévère et prolongée. Enfin, les perspectives thérapeutiques envisageables seront abordées.

Mots clés

Mitochondrie Sepsis Défaillance multiviscérale Physiopathologie Traitement 

Mitochondrie — rôles clés dans le sepsis

Abstract

The pathophysiological mechanisms underpinning the development of, and recovery from, sepsis-induced organ failure require further delineation. Mitochondrial dysfunction may well play a key role. This review will therefore consider mitochondria’s function in normal physiology, evidence linking bioenergetic alterations to organ dysfunction after severe and prolonged inflammation, and potential therapeutic strategies that may be applied.

Keywords

Mitochondria Sepsis Multi-organ failure Pathophysiology Therapeutics 
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Copyright information

© Société de réanimation de langue française (SRLF) and Springer-Verlag France 2012

Authors and Affiliations

  1. 1.Bloomsbury Institute of Intensive Care Medicine, Department of MedicineUniversity College LondonLondonUK

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