Electrochemical methods to enhance osseointegrated prostheses

  • Mark T. EhrensbergerEmail author
  • Caelen M. Clark
  • Mary K. Canty
  • Eric P. McDermott
Review Article


Osseointegrated (OI) prosthetic limbs have been shown to provide an advantageous treatment option for amputees. In order for the OI prosthesis to be successful, the titanium implant must rapidly achieve and maintain proper integration with the bone tissue and remain free of infection. Electrochemical methods can be utilized to control and/or monitor the interfacial microenvironment where the titanium implant interacts with the biological system (host bone tissue or bacteria). This review will summarize the current understanding of how electrochemical modalities can influence bone tissue and bacteria with specific emphasis on applications where the metallic prosthesis itself can be utilized directly as a stimulating electrode for enhanced osseointegration and infection control. In addition, a summary of electrochemical impedance sensing techniques that could be used to potentially assess osseointegration and infection status of the metallic prosthesis is presented.


Osseointegration Implant associated infection Electrical stimulation Osteogenesis Biofilms Electrochemical impedance spectroscopy 



MTE has received research grants from the Office of Naval Research, Garwood Medical Devices, Zimmer Biomet, Depuy Synthes, and Lima Corporate.


Office of Naval Research Grant: N00014-16-1-3187 (MTE).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The authors did not perform any studies with human participants or animals to write this review article.


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Copyright information

© Korean Society of Medical and Biological Engineering 2019

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringUniversity at BuffaloBuffaloUSA
  2. 2.Department of OrthopaedicsUniversity at BuffaloBuffaloUSA
  3. 3.Department of Microbiology and ImmunologyUniversity at BuffaloBuffaloUSA

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