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Optical coherence tomography angiography in preclinical neuroimaging

  • Woo June ChoiEmail author
Review Article
  • 31 Downloads

Abstract

Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity, and function in laboratory animals, such as mice and this imaging field has been a rapidly growing aimed at bridging the translation gap between animal and human research. The progress in the animal research could be accelerated by high-resolution in vivo optical imaging technologies. Optical coherence tomography-based angiography (OCTA) estimates the scattering from moving red blood cells, providing the visualization of functional micro-vessel networks within tissue beds in vivo without a need for exogenous contrast agents. Recent advancement of OCTA methods have expanded its application to neuroimaging of small animal models of brain disorders. In this paper, we overview the recent development of OCTA techniques for blood flow imaging and its preclinical applications in neuroimaging. In specific, a summary of preclinical OCTA studies for traumatic brain injury, cerebral stroke, and aging brain on mice is reviewed.

Keywords

Optical coherence tomography Angiography Preclinical neuroimaging, small animal models Traumatic brain injury, stroke, aging 

Notes

Acknowledgements

This research was supported by the Chung-Ang University Research Grants in 2018.

Funding

This study was funded by the Chung-Ang University Research Grants in 2018.

Compliance with ethical standards

Conflict of interest

Dr. Choi has no conflicts of interest to declare.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Korean Society of Medical and Biological Engineering 2019

Authors and Affiliations

  1. 1.School of Electrical and Electronics Engineering, College of ICT EngineeringChung-Ang UniversitySeoulRepublic of Korea

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