Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane
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This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 104 cells/cm2 and implanted onto a rat’s 1.50 × 1.50 cm2 full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
KeywordsAmniotic membrane Wound healing Menstrual blood-derived stem cells
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal experiments were approved by the ethical committee of Shahroud University of Medical Sciences and were carried out in accordance with the university’s guidelines.
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