Biomedical Engineering Letters

, Volume 8, Issue 3, pp 267–272 | Cite as

Mechanical properties and cytotoxicity of PLA/PCL films

  • Heeseok Jeong
  • Jeongwon Rho
  • Ji-Yeon Shin
  • Deuk Yong Lee
  • Taeseon Hwang
  • Kwang J. Kim
Original Article


Thermodynamically immiscible poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) were blended and solution-cast by adding the 3% compatibilizer (tributyl citrate, TBC) of the PCL weight. In the PLA/PCL composition range of 99/1–95/5 wt%, mechanical properties of the PLA/PCL films with TBC were always superior to those of the films without TBC. The tensile strength of 42.9 ± 3.5 MPa and the elongation at break of 10.3 ± 2.7% were observed for the 93/7 PLA/PCL films without TBC, indicating that PCL addition is effective for strength and ductility. However, the tensile strength of 54.1 ± 3.4 MPa and the elongation at break of 8.8 ± 1.8% were found for the 95/5 PLA/PCL with TBC, indicating that the effect of co-addition of PCL and TBC on mechanical properties of the films is more pronounced. No cytotoxicity was observed for the PLA/PCL films regardless of TBC addition.


Poly(lactic acid) Poly(ε-caprolactone) Compatibilizer Tensile strength Cytotoxicity Cell proliferation 



KJK and TH would like to acknowledge this material is based upon work supported in part by the National Science Foundation under Grant No. IIA-1301726.

Compliance with ethical standards

Conflict of interest

The authors declares there is no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Korean Society of Medical and Biological Engineering and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Convergence Institute of Biomedical Engineering and BiomaterialsSeoul National University of Science and TechnologySeoulKorea
  2. 2.Department of Biomedical EngineeringDaelim UniversityAnyangKorea
  3. 3.Department of Mechanical EngineeringUniversity of NevadaLas VegasUSA

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