Advertisement

Additive manufacturing to veterinary practice: recovery of bony defects after the osteosarcoma resection in canines

  • Vladimir V. PopovJr.
  • Gary Muller-Kamskii
  • Alexander Katz-Demyanetz
  • Aleksey Kovalevsky
  • Stas Usov
  • Dmitrii Trofimcow
  • Georgy Dzhenzhera
  • Andrey Koptyug
Review Article
  • 23 Downloads

Abstract

The paper outlines the achievements and challenges in the additive manufacturing (AM) application to veterinary practice. The state-of-the-art in AM application to the veterinary surgery is presented, with the focus of AM for patient-specific implants manufacturing. It also provides critical discussion on some of the potential issues design and technology should overcome for wider and more effective implementation of additively manufactured parts in veterinary practices. Most of the discussions in present paper are related to the metallic implants, manufactured in this case using so-called powder bed additive manufacturing (PB-AM) in titanium alloy Ti–6AL–4V, and to the corresponding process of their design, manufacturing and implementation in veterinary surgery. Procedures of the implant design and individualization for veterinary surgery are illustrated basing on the four performed surgery cases with dog patients. Results of the replacement surgery in dogs indicate that individualized additively manufactured metallic implants significantly increase chances for successful recovery process, and AM techniques present a viable alternative to amputation in a large number of veterinary cases. The same time overcoming challenges of implant individualization in veterinary practice significantly contributes to the knowledge directly relevant to the modern medical practice. An experience from veterinary cases where organ-preserving surgery with 3D-printed patient-specific implants is performed provides a unique opportunity for future development of better human implants.

Keywords

Additive manufacturing Ti–6Al–4V Implants Veterinary applications of 3D printing Clinical cases Osteosarcoma Dogs 

Notes

Acknowledgements

Authors want to thank Dr. Jorge Leite, Bonematrix (Portugal) for fruitful joint work on the 4th case and conducting the challenging surgery; Haim Rosenson and Dr. Jean Ramon for support of biomedical activities in Israel Institute of Metals (IIM); the IIM team for conducting all the necessary 3D printing and testing activities.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Ethical approval was obtained in Russia (cases 1–3) and Portugal (case 4) according to the local guidelines for the care and use of animals.

References

  1. 1.
    The social and economic value of pets to human society, The Telegraph (UK). 2017. https://www.telegraph.co.uk/pets/news-features/social-economic-value-pets-human-society/.
  2. 2.
    Hall S, Dolling L, Bristow K, Fuller T, Mills D. Companion animal economics. The economic impact of companion animals in the UK. S CABI (Centre for Agriculture and Biosciences International), Paperback. 2017.  https://doi.org/10.1079/9781786391728.0000.
  3. 3.
    Saunders J, Parast L, Babey SH, Miles JV. Exploring the differences between pet and non-pet owners: implications for human-animal interaction research and policy. PLoS ONE. 2017;12(6):e0179494.  https://doi.org/10.1371/journal.pone.0179494.CrossRefGoogle Scholar
  4. 4.
    Herzog H. The impact of pets on human health and psychological well-being fact, fiction, or hypothesis? Curr Dir Psychol Sci. 2011;20(4):236–9.CrossRefGoogle Scholar
  5. 5.
    Cutt H, Giles-Corti B, Knuiman M, Timperio A, Bull F. Understanding dog owners’ increased levels of physical activity: results from RESIDE. Am J Public Health. 2008;98(1):66–9.  https://doi.org/10.2105/AJPH.2006.103499.CrossRefGoogle Scholar
  6. 6.
    Shiloh S, Sorekt G, Terkel J. Reduction of state-anxiety by petting animals in a controlled laboratory experiment. Anxiety Stress Coping. 2010;16(4):387–95.  https://doi.org/10.1080/1061580031000091582.CrossRefGoogle Scholar
  7. 7.
    Beetz A, Uvnäs-Moberg K, Julius H, Kotrschal K. Psychosocial and psychophysiological effects of human–animal interactions: the possible role of oxytocin. Front Psychol. 2012;3:234.Google Scholar
  8. 8.
    Nimer J, Lundahl B. Animal-assisted therapy: a meta-analysis. Anthrozoos. 2007;20(3):225–38.CrossRefGoogle Scholar
  9. 9.
    Herderick E. Additive manufacturing of metals: a review, vol 2; 2011. p. 1413–1425.Google Scholar
  10. 10.
    Koptyug A, Rännar L, Bäckström M, Cronskär M. Additive manufacturing for medical and biomedical applications: advances and challenges. In: Materials science forum; 2014. p. 1286–1291.Google Scholar
  11. 11.
    Kolomiets A, Popov V, Strokin E, Muller G, Kovalevsky A. Benefits of additive manufacturing for industrial design development. Trends, limitations and applications. Glob J Res Eng. 2018;18(2).Google Scholar
  12. 12.
    Popov VV, Muller-Kamskii G, Kovalevsky A, et al. Design and 3D-printing of titanium bone implants: brief review of approach and clinical cases. Biomed Eng Lett. 2018;8:337.  https://doi.org/10.1007/s13534-018-0080-5.CrossRefGoogle Scholar
  13. 13.
    Harrysson OLA, Marcellin-Little DJ, Horn TJ. Applications of metal additive manufacturing in veterinary orthopedic surgery. JOM J Miner Met Mater Soc. 2015;67(3):647–54.CrossRefGoogle Scholar
  14. 14.
    Song C, Wang A, Wu Z, Chen Z, Yang Y, Wang D. The design and manufacturing of a titanium alloy beak for Grus japonensis using additive manufacturing. Mater Des. 2016.  https://doi.org/10.1016/j.matdes.2016.11.092.Google Scholar
  15. 15.
    Nickels L. Positive prognosis for 3D printed animal implants. Metal Powder Rep. 2018.  https://doi.org/10.1016/j.mprp.2018.02.036.Google Scholar
  16. 16.
    Osmar R. Veterinary additive manufacturing: development of a prosthesis of a toucan’s bill. In: Conference: RAPID 2015; 2015.Google Scholar
  17. 17.
    Horal M. 3D printing implants for fracture healing studies in rats. Department of Biomedical Engineering. 2015.  https://doi.org/10.5703/1288284315910. http://lup.lub.lu.se/luur/download?func=downloadFile&recordOId=8310516&fileOId=8310520.
  18. 18.
    Boston SE, Skinner OT. Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog. Vet Surg. 2018;47:136–45.  https://doi.org/10.1111/vsu.12726.CrossRefGoogle Scholar
  19. 19.
    Mitchell KE, Boston SE, Kung M, Dry S, Straw RC, Ehrhart NP, Ryan SD. Outcomes of limb-sparing surgery using two generations of metal endoprosthesis in 45 dogs with distal radial osteosarcoma. A veterinary society of surgical oncology retrospective study. Vet Surg. 2016;45:36–43.  https://doi.org/10.1111/vsu.12423.CrossRefGoogle Scholar
  20. 20.
    Seguin B, O’Donnell MD, Walsh PJ, Selmic LE. Long-term outcome of dogs treated with ulnar rollover transposition for limb-sparing of distal radial osteosarcoma: 27 limbs in 26 dogs. Vet Surg. 2017;46:1017–24.  https://doi.org/10.1111/vsu.12698.CrossRefGoogle Scholar
  21. 21.
    MacDonald TL, Schiller TD. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J. 2010;51:497–500.Google Scholar
  22. 22.
    Nazarali A, Singh A, Morrison S, Gibson TWG, Rousseau J, Weese JS, Boston SE. Comparison of methicillin-resistant Staphylococcus pseudintermedius adherence to 2 canine limb salvage endoprosthesis implants. Can Vet J. 2017;58:964–6.Google Scholar
  23. 23.
    Quinn-Gorham DM, Khan JM. Thinking outside of the box: the potential of 3D printing in veterinary medicine. J Vet Sci Technol. 2016;7:360.  https://doi.org/10.4172/2157-7579.1000360.Google Scholar
  24. 24.
    Koptyug A, Rännar L, Bäckström M, Fager Franzén S, Dérand P. Additive manufacturing technology applications targeting practical surgery. Int J Life Sci Med Res. 2013;3(1):15–24.CrossRefGoogle Scholar
  25. 25.
    Heinl P, Müller L, Körner C, Singer RF, Müller FA. Cellular Ti–6Al–4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. Acta Biomater. 2008;4(5):1536–44.CrossRefGoogle Scholar
  26. 26.
    Renishaw. Case study “Additive manufacturing in veterinary surgery—saving a well-loved member of the family”. http://resources.renishaw.com/en/download/case-study-additive-manufacturing-in-veterinary-surgery-saving-a-well-loved-member-of-the-family--98590.
  27. 27.
    Aikman S, McGee J, Meile A, Powell B, Gogard J, Bitter T. “Puppy prosthetic—custom 3D printed dog prosthetic”, P17061. http://edge.rit.edu/edge/P17061/public/Customer%20Handoff%20and%20Final%20Project%20Documentation/MSD_Final_Paper_ver2_4_25_17.pdf.
  28. 28.
    Bachman N, Lasso M, Olaode O, Walfield E, Zuhairi MA. Design of a prosthesis for canines with front limb deformities. A Major Qualifying Project Report submitted to the faculty of Worcester Polytechnic Institute in partial fulfillment of the requirements for the degree of Bachelor of Science. 2017. https://web.wpi.edu/Pubs/E-project/Available/E-project-042717-151238/unrestricted/MQPReport.pdf.
  29. 29.
    Ruppert DS, Harrysson OLA, Marcellin-Little DJ, Dahners LE, Weinhold PS. Improved osseointegration with as-built electron beam melted textured implants and improved peri-implant bone volume with whole body vibration. Med Eng Phys. 2018.  https://doi.org/10.1016/j.medengphy.2018.05.003.Google Scholar
  30. 30.
    ASTM F1472-14, Standard specification for wrought titanium–6aluminum–4vanadium alloy for surgical implant applications (UNS R56400). West Conshohocken: ASTM International; 2014. https://www.astm.org/Standards/F1472.htm.
  31. 31.
    ASTM E466 - 07, Standard practice for conducting force controlled constant amplitude axial fatigue tests of metallic materials. https://www.astm.org/DATABASE.CART/HISTORICAL/E466-07.htm.
  32. 32.
    ASTM E23 - Standard test methods for notched bar impact testing of metallic materials. https://www.astm.org/Standards/E23.
  33. 33.
    Surmeneva MA, Surmenev R, Chudinova EA, Koptioug A, Tkachev MS, Gorodzha SN, Rännar L. Fabrication of multiple-layered gradient cellular metal scaffold via electron beam melting for segmental bone reconstruction. Mater Des. 2017;133:195–204.CrossRefGoogle Scholar
  34. 34.
    Regis M, Marin E, Fedrizzi L, Pressacco M. Additive manufacturing of trabecular titanium orthopedic implants. MRS Bull. 2015;40(02):137–44.CrossRefGoogle Scholar
  35. 35.
    Xiong Y, Zhao Y, Wang Z, Du Q, Chen W, Wang A. Comparison of a new minimum contact locking plate and the limited contact dynamic compression plate in an osteoporotic fracture model. Int Orthop. 2009;33(5):1415–9.  https://doi.org/10.1007/s00264-008-0713-x.CrossRefGoogle Scholar
  36. 36.
    Boyer R, Welsch G, Collings EW. Materials properties handbook: titanium alloys. Metals Park: ASM International; 1994.Google Scholar
  37. 37.
    Metals handbook, volume 2—properties and selection: nonferrous alloys and special-purpose materials, 10th edn. ASM International; 1990.Google Scholar
  38. 38.
    Metals handbook, volume 3, properties and selection: stainless steels, tool materials and special-purpose metals, ninth edition, ASM Handbook Committee. Materials Park: American Society for Metals; 1980.Google Scholar
  39. 39.
    Holt JM, Ho CY, editors. Structural alloys handbook, 1996 edition. West Lafayette: CINDAS/Purdue University; 1996.Google Scholar
  40. 40.
    Popov V, Katz-Demyanetz A, Garkun A, Muller G, Strokin E, Rosenson H. Effect of hot isostatic pressure treatment on the electron-beam melted Ti–6Al–4V specimens. Procedia Manuf. 2018;21:125–32.  https://doi.org/10.1016/j.promfg.2018.02.102.CrossRefGoogle Scholar
  41. 41.
    Popov VV Jr, Katz-Demyanetz A, Garkun A, Bamberger M. The effect of powder recycling on the mechanical properties and microstructure of electron beam melted Ti–6Al–4V specimens. Addit Manuf. 2018;22:834–43.  https://doi.org/10.1016/j.addma.2018.06.003.CrossRefGoogle Scholar

Copyright information

© Korean Society of Medical and Biological Engineering 2019

Authors and Affiliations

  1. 1.Israel Institute of MetalsTechnion R&D FoundationTechnion City, HaifaIsrael
  2. 2.Veterinary Clinic Ortho-VetSaint-PetersburgRussia
  3. 3.Veterinary Clinic Beliy KlykMoscowRussia
  4. 4.Polygon Medical EngineeringMoscowRussia
  5. 5.Sports Tech Research CentreMid Sweden UniversityÖstersundSweden

Personalised recommendations