Additive manufacturing to veterinary practice: recovery of bony defects after the osteosarcoma resection in canines
- 23 Downloads
The paper outlines the achievements and challenges in the additive manufacturing (AM) application to veterinary practice. The state-of-the-art in AM application to the veterinary surgery is presented, with the focus of AM for patient-specific implants manufacturing. It also provides critical discussion on some of the potential issues design and technology should overcome for wider and more effective implementation of additively manufactured parts in veterinary practices. Most of the discussions in present paper are related to the metallic implants, manufactured in this case using so-called powder bed additive manufacturing (PB-AM) in titanium alloy Ti–6AL–4V, and to the corresponding process of their design, manufacturing and implementation in veterinary surgery. Procedures of the implant design and individualization for veterinary surgery are illustrated basing on the four performed surgery cases with dog patients. Results of the replacement surgery in dogs indicate that individualized additively manufactured metallic implants significantly increase chances for successful recovery process, and AM techniques present a viable alternative to amputation in a large number of veterinary cases. The same time overcoming challenges of implant individualization in veterinary practice significantly contributes to the knowledge directly relevant to the modern medical practice. An experience from veterinary cases where organ-preserving surgery with 3D-printed patient-specific implants is performed provides a unique opportunity for future development of better human implants.
KeywordsAdditive manufacturing Ti–6Al–4V Implants Veterinary applications of 3D printing Clinical cases Osteosarcoma Dogs
Authors want to thank Dr. Jorge Leite, Bonematrix (Portugal) for fruitful joint work on the 4th case and conducting the challenging surgery; Haim Rosenson and Dr. Jean Ramon for support of biomedical activities in Israel Institute of Metals (IIM); the IIM team for conducting all the necessary 3D printing and testing activities.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval was obtained in Russia (cases 1–3) and Portugal (case 4) according to the local guidelines for the care and use of animals.
- 1.The social and economic value of pets to human society, The Telegraph (UK). 2017. https://www.telegraph.co.uk/pets/news-features/social-economic-value-pets-human-society/.
- 2.Hall S, Dolling L, Bristow K, Fuller T, Mills D. Companion animal economics. The economic impact of companion animals in the UK. S CABI (Centre for Agriculture and Biosciences International), Paperback. 2017. https://doi.org/10.1079/9781786391728.0000.
- 7.Beetz A, Uvnäs-Moberg K, Julius H, Kotrschal K. Psychosocial and psychophysiological effects of human–animal interactions: the possible role of oxytocin. Front Psychol. 2012;3:234.Google Scholar
- 9.Herderick E. Additive manufacturing of metals: a review, vol 2; 2011. p. 1413–1425.Google Scholar
- 10.Koptyug A, Rännar L, Bäckström M, Cronskär M. Additive manufacturing for medical and biomedical applications: advances and challenges. In: Materials science forum; 2014. p. 1286–1291.Google Scholar
- 11.Kolomiets A, Popov V, Strokin E, Muller G, Kovalevsky A. Benefits of additive manufacturing for industrial design development. Trends, limitations and applications. Glob J Res Eng. 2018;18(2).Google Scholar
- 16.Osmar R. Veterinary additive manufacturing: development of a prosthesis of a toucan’s bill. In: Conference: RAPID 2015; 2015.Google Scholar
- 17.Horal M. 3D printing implants for fracture healing studies in rats. Department of Biomedical Engineering. 2015. https://doi.org/10.5703/1288284315910. http://lup.lub.lu.se/luur/download?func=downloadFile&recordOId=8310516&fileOId=8310520.
- 19.Mitchell KE, Boston SE, Kung M, Dry S, Straw RC, Ehrhart NP, Ryan SD. Outcomes of limb-sparing surgery using two generations of metal endoprosthesis in 45 dogs with distal radial osteosarcoma. A veterinary society of surgical oncology retrospective study. Vet Surg. 2016;45:36–43. https://doi.org/10.1111/vsu.12423.CrossRefGoogle Scholar
- 21.MacDonald TL, Schiller TD. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J. 2010;51:497–500.Google Scholar
- 22.Nazarali A, Singh A, Morrison S, Gibson TWG, Rousseau J, Weese JS, Boston SE. Comparison of methicillin-resistant Staphylococcus pseudintermedius adherence to 2 canine limb salvage endoprosthesis implants. Can Vet J. 2017;58:964–6.Google Scholar
- 26.Renishaw. Case study “Additive manufacturing in veterinary surgery—saving a well-loved member of the family”. http://resources.renishaw.com/en/download/case-study-additive-manufacturing-in-veterinary-surgery-saving-a-well-loved-member-of-the-family--98590.
- 27.Aikman S, McGee J, Meile A, Powell B, Gogard J, Bitter T. “Puppy prosthetic—custom 3D printed dog prosthetic”, P17061. http://edge.rit.edu/edge/P17061/public/Customer%20Handoff%20and%20Final%20Project%20Documentation/MSD_Final_Paper_ver2_4_25_17.pdf.
- 28.Bachman N, Lasso M, Olaode O, Walfield E, Zuhairi MA. Design of a prosthesis for canines with front limb deformities. A Major Qualifying Project Report submitted to the faculty of Worcester Polytechnic Institute in partial fulfillment of the requirements for the degree of Bachelor of Science. 2017. https://web.wpi.edu/Pubs/E-project/Available/E-project-042717-151238/unrestricted/MQPReport.pdf.
- 30.ASTM F1472-14, Standard specification for wrought titanium–6aluminum–4vanadium alloy for surgical implant applications (UNS R56400). West Conshohocken: ASTM International; 2014. https://www.astm.org/Standards/F1472.htm.
- 31.ASTM E466 - 07, Standard practice for conducting force controlled constant amplitude axial fatigue tests of metallic materials. https://www.astm.org/DATABASE.CART/HISTORICAL/E466-07.htm.
- 32.ASTM E23 - Standard test methods for notched bar impact testing of metallic materials. https://www.astm.org/Standards/E23.
- 36.Boyer R, Welsch G, Collings EW. Materials properties handbook: titanium alloys. Metals Park: ASM International; 1994.Google Scholar
- 37.Metals handbook, volume 2—properties and selection: nonferrous alloys and special-purpose materials, 10th edn. ASM International; 1990.Google Scholar
- 38.Metals handbook, volume 3, properties and selection: stainless steels, tool materials and special-purpose metals, ninth edition, ASM Handbook Committee. Materials Park: American Society for Metals; 1980.Google Scholar
- 39.Holt JM, Ho CY, editors. Structural alloys handbook, 1996 edition. West Lafayette: CINDAS/Purdue University; 1996.Google Scholar