Biomedical Engineering Letters

, Volume 5, Issue 4, pp 289–295 | Cite as

Analysis of force acting on the non-spherical particle near a wall

Original Article
First Online:
Received:
Revised:
Accepted:

Abstract

Purpose

To investigate the non-spherical particle dynamics near a wall in a vasculature, it is required that detailed force with respect to the particle angle and separation distance. The prismatic particles with different cross sections are employed to study the forces on the particle in linear shear flow.

Methods

The force on the particle at the proximity of the wall in linear shear flow is evaluated. Fluid dynamics simulation is performed by using Fluent software. To investigate the effect of particle non-sphericity, triangular, rectangular and hexagonal prisms are considered.

Results

As the particle places close to the wall, the interaction between particle and wall increase. Due to the particle nonsphericity, the periodic force fluctuation is observed and this feature is important as the particle approaches to the wall. The number of apex of the cross sectional geometry is significant on the force on the particle by fluid.

Conclusions

The interaction between particle and the wall induces force imbalance so that it is predicted that the particle geometry will influence on the particle dynamics in the vascular flow. The particle cross sectional shape and particle non-sphericity are important factors in designing particlebased drug delivery system.

Keywords

Drug delivery system Shear flow Drag and resistant force Non-spherical particle Migration 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Champion JA, Katare YK, Mitragotri S. Making polymeric micro- and nanoparticles of complex shapes. Proc Natl Acad Sci USA. 2007; 104(29):11901–4.CrossRefGoogle Scholar
  2. [2]
    Gratton SE, Pohlhaus PD, Lee J, Guo J, Cho MJ, Desimone JM. Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J Control Release. 2007; 121(1):2–10.Google Scholar
  3. [3]
    Piao Y, Jang Y, Shokouhimehr M, Lee IS, Hyeon T. Facile aqueous-phase synthesis of uniform palladium nanoparticles of various shapes and sizes. Small. 2007; 3(2):255–60.CrossRefGoogle Scholar
  4. [4]
    Tasciotti E, Liu X, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MM, Decuzzi P, Tour JM, Robertson F, Ferrari M. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008; 3:151–7.CrossRefGoogle Scholar
  5. [5]
    Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer. 2005; 5(3):161–71.CrossRefGoogle Scholar
  6. [6]
    Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular Delivery of Particulate Systems: Does Geometry Really Matter? Pharm Res. 2009; 26(1):235–43.CrossRefGoogle Scholar
  7. [7]
    Goldman AJ, Cox RG, Brenner H. Slow viscous motion of a sphere parallel to a plane wall - I Motion in a quiescent fluid. Chem Eng Sci. 1967; 22(4):637–51.CrossRefGoogle Scholar
  8. [8]
    Goldman AJ, Cox RG, Brenner H. Slow viscous motion of a sphere parallel to a plane wall - II Couette flow. Chem Eng Sci. 1967; 22(4):653–60.CrossRefGoogle Scholar
  9. [9]
    Jeffery GB. The motion of ellipsoidal particles immersed in a viscous fluid. Proc R Soc Lond A. 1922; 102(715):161–79.CrossRefMATHGoogle Scholar
  10. [10]
    Gavze E, Shapiro M. Particles in a shear flow near a solid wall: effect of nonsphericity on forces and velocities. Int J Multiphase Flow. 1997; 23(1):155–82.CrossRefMATHGoogle Scholar
  11. [11]
    Gavze E, Shapiro M. Motion of inertial spheroidal particles in a shear flow near a solid wall with special application to aerosol transport in microgravity. J Fluid Mech. 1998; 371:59–79.CrossRefMATHGoogle Scholar
  12. [12]
    Broday D, Fichman M, Shapiro M, Gutfinger C. Motion of spheroidal particles in vertical shear flows. Phys Fluids. 1998; 10(1):80–100.MathSciNetCrossRefMATHGoogle Scholar
  13. [13]
    Lee SY, Ferrari M, Decuzzi P. Design of bio-mimetic particles with enhanced vascular interaction. J Biomech. 2009; 42(12):1885–90.CrossRefGoogle Scholar
  14. [14]
    Lee SY, Ferrari M, Decuzzi P. Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows. Nanotechnology. 2009; doi:  10.1088/0957-4484/20/49/495101.Google Scholar
  15. [15]
    Decuzzi P, Ferrari M. The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials. 2006; 27(30):5307–14.CrossRefGoogle Scholar
  16. [16]
    Decuzzi P, Ferrari M. Design maps for nanoparticles targeting the diseased microvasculature. Biomaterials. 2008; 29(3):377–84.CrossRefGoogle Scholar
  17. [17]
    Gentile F, Chiappini C, Fine D, Bhavane RC, Peluccio MS, Cheng MM, Liu X, Ferrari M, Decuzzi P. The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows. J Biomech. 2008; 41(10):2312–8.CrossRefGoogle Scholar
  18. [18]
    Adriani G, de Tullio MD, Ferrari M, Hussain F, Pascazio G, Liu X, Decuzzi P. The preferential targeting of the diseased microvasculature by disk-like particles. Biomaterials. 2012; 33(22):5504–13.CrossRefGoogle Scholar
  19. [19]
    Lee SY, Zaske AM, Novellino T, Danila D, Ferrari M, Conyers J, Decuzzi P. Probing the mechanical properties of TNF-alpha stimulated endothelial cell with atomic force microscopy. Int J Nanomedicine. 2011; 6:179–95.CrossRefGoogle Scholar
  20. [20]
    Boso DP, Lee SY, Ferrari M, Schrefler BA, Decuzzi P. Optimizing particle size for targeting diseased microvasculature: from experiments to artificial neural networks. Int J Nanomedicine. 2011; 6:1517–26.CrossRefGoogle Scholar

Copyright information

© Korean Society of Medical and Biological Engineering and Springer 2015

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringYonsei UniversityWonju, KangwonRepublic of Korea

Personalised recommendations