Dermatologic Changes in the Condition of Skin after Low Frequency Electric Field in Healthy Korean Men

  • So-Jung Kim
  • Seung-Min Yang
  • Jaehong Park
  • Junghwan KimEmail author



The objective of this study was to change in skin conditions before and after application of low frequency electric field (also called transcutaneous electrical stimulation) to regions of the bodies of healthy male.


The study consisted of 30 healthy Korean males in their 20 s. Differences in skin sebum content, moisture content, pore size, wrinkle type, pigmentation, and elasticity of three regions were assessed before and after low frequency electric field. A commercial skin diagnosis meter was used for skin-related measurements.


The results revealed a statistically significant difference in pre-versus post-measurement values in moisture content, wrinkle type, pigmentation, and elasticity. As shown by the results of the correlation analysis, sebum content and pigmentation, moisture content and elasticity, and wrinkle type and pigmentation were positively correlated.


The results provide evidence that external stimulation was associated with skin-related changes. The effect of low frequency electric field on skin-related parameters may differ according to the body part.


Skin health Low frequency electric field Workers Healthy volunteers 


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This work was supported in part by the Dan-Ho educational institution and Korea Southern Power Plant, South Korea.


  1. 1.
    Man, M. Q. et al. Variation of skin surface pH, sThe results provide evidence that external stimulation was associated with skin-related changes. The effect of low frequency electric field on skin-related parameters may differ according to the body part.ebum content and stratum corneum hydration with age and gender in a large Chinese Population. Skin Pharmacol. Physiol. 22, 190–199 (2009).CrossRefGoogle Scholar
  2. 2.
    Ohta, H. et al. Relationship between dermato-physiological changes and hormonal status in pre-, peri-, and postmenopausal women. Maturitas 30, 55–62 (1998).CrossRefGoogle Scholar
  3. 3.
    Tomita, Y., Akiyama, M. & Shimizu, H. Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis. Exp. Dermatol. 14, 619–624 (2005).CrossRefGoogle Scholar
  4. 4.
    Burke, K. E. & Wei, H. Synergistic damage by UVA radiation and pollutants. Toxicol. Ind. Health 25, 219–224 (2009).CrossRefGoogle Scholar
  5. 5.
    Noh, J. W. et al. Differences in two-point discrimination and sensory threshold in the blind between Braille and text reading: a pilot study. J. Phys. Ther. Sci. 27, 1919–1922 (2015).CrossRefGoogle Scholar
  6. 6.
    Jeon, H. J. et al. Analysis of high-frequency transcutaneous electrical nerve stimulation-induced sensory threshold from the elderly people for healthy life. Toxcol. Environ. Health Sci. 4, 167–172 (2012).CrossRefGoogle Scholar
  7. 7.
    Scudds, R. J., Helewa, A. & Scudds, R. A. The effects of transcutaneous electrical nerve stimulation on skin temperature in asymptomatic subjects. Phys. Ther. 75, 621–628 (1995).CrossRefGoogle Scholar
  8. 8.
    Kaada, B., Olsen, E. & Eielsen, O. In serach of mediators of skin vasodilation induced by transcutaneous nerve stimulation: III. Increase in plasma VIP in normal subjects and Raynaud’s disease. Gen. Pharmacol. 15, 107–113 (1984).CrossRefGoogle Scholar
  9. 9.
    Pillai, S., Oresajo, C. & Hayward, J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation — a review. Int. J. Cosmet. Sci. 27, 17–34 (2005).CrossRefGoogle Scholar
  10. 10.
    Imokawa, G. Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase. J. Investig. Dermatol. Symp. Proc. 14, 36–43 (2009).CrossRefGoogle Scholar
  11. 11.
    Lee, W. D. et al. Differences in theobase and chronaxie between the paretic and non-paretic sides of hemiplegic stroke patients: pilot study. J. Phys. Ther. Sci. 25, 717–719 (2013).CrossRefGoogle Scholar
  12. 12.
    Bourguignon, G. J., Jy, W. & Bourguignon, L. Y. Electric stimulation of human fibroblasts cause an increase in Ca2+ influx and the exposure of additional insulin receptor. J. Cell. Physiol. 140, 379–85 (1989).CrossRefGoogle Scholar
  13. 13.
    Kanitakis, J. Anatomy, histology and immunohistochemistry of normal human skin. J. Dermatol. 12, 390–399 (2002).Google Scholar
  14. 14.
    Canseven, A. G. & Atalay, N. S. Is it possible to trigger collagen synthesis by electric current in skin wound? Indian J. Biochem. Biophys. 33, 223–227 (1996).Google Scholar
  15. 15.
    João De Masi, E. C. et al. The influence of growth factors on skin wound healing in rats. Braz. J. Otorhinolaryngol. 82, 512–521 (2016).CrossRefGoogle Scholar
  16. 16.
    Kloth, L. C. Electrical stimulation for wound healing: a review of evidence from in vitro studies, animal experiments, and clinical trials. Int. J. Low. Extrem. Wounds. 4, 23–44 (2005).CrossRefGoogle Scholar
  17. 17.
    Koca Kutlu, A. et al. Comparison study of growth factor expression following treatment with transcutaneous electrical nerve stimulation, saline solution, povidone-iodine, and lavender oil in wounds healing. Evid Based Complement. Alternat. Med. 2013, 361832 (2013).CrossRefGoogle Scholar
  18. 18.
    Torkaman, G. Electrical stimulation of wound healing: a review of animal experimental evidence. Adv. Wound Care (New Rochelle). 3, 202–218 (2014).CrossRefGoogle Scholar
  19. 19.
    Thakral, G. et al. Electrical stimulation to accelerate wound healing. Diabet Foot Ankle. 4, 1–9 (2013).CrossRefGoogle Scholar
  20. 20.
    Ignotz, R. A. & Massagué, J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261, 4337–4345 (1986).Google Scholar
  21. 21.
    Baumann, L. Skin ageing and its treatment. J. Pathol. 211, 241–251 (2007).CrossRefGoogle Scholar
  22. 22.
    Pittayapruek, P. et al. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int. J. Mol. Sci. 17, 868 (2016).CrossRefGoogle Scholar
  23. 23.
    Panich, U. et al. Ultraviolet radiation-induced skin aging: the role of DNA damage and oxidative stress in epidermal stem cell damage mediated skin aging. Stem Cells Int. 2016, 1–14 (2016).CrossRefGoogle Scholar
  24. 24.
    Rim, K. T. Genetic biomarkers and their applications to prevent occupational diseases: a literature review. Toxcol. Environ. Health Sci. 10, 147–156 (2018).CrossRefGoogle Scholar
  25. 25.
    Lee, L. K. et al. A review of cardiovascular disease in Korean shift workers and the approach to improve their health at Y power plant. Trans. Rev. 25, 4357–4363 (2017).Google Scholar
  26. 26.
    Yang, J. H. et al. Considerations of human health risk assessment in chemical accident: suggestions from a toxicogenomic approach. Toxcol. Environ. Health Sci. 10, 79–89 (2018).Google Scholar
  27. 27.
    Kim, M. Y. et al. The effect of low frequency repetitive transcranial magnetic stimulation combined with range of motion exercise on paretic hand function in female patients after stroke. Neurosci. Med. 4, 77–83 (2013).CrossRefGoogle Scholar

Copyright information

© The Korean Society of Environmental Risk Assessment and Health Science and Springer 2019

Authors and Affiliations

  • So-Jung Kim
    • 1
  • Seung-Min Yang
    • 1
  • Jaehong Park
    • 2
  • Junghwan Kim
    • 3
    Email author
  1. 1.Laboratory of Health Science & Nanophysiotherapy, Department of Physical Therapy, Graduate SchoolYongin UniversityYonginRepublic of Korea
  2. 2.Department of Social Welfare, College of Public Health & WelfareYongin UniversityYonginRepublic of Korea
  3. 3.Department of Physical Therapy, College of Public Health & WelfareYongin UniversityYonginRepublic of Korea

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