Meta-analysis of microarray datasets for the risk assessment of coplanar polychlorinated biphenyl 77 (PCB77) on human health

  • Junghyun Jung
  • Kyoungyoung Hah
  • Woosuk Lee
  • Wonhee Jang
Original article
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Abstract

Polychlorinated biphenyls (PCBs) are persistent organic compounds that have been banned since 1970s, but continue to contaminate the environment. PCBs are categorized into two structural groups: coplanar and non-coplanar PCBs. The coplanar PCBs are dioxin-like potent toxic compounds. To evaluate their effects on humans, we chose a coplanar PCB77 for data analysis. We performed meta- analysis by integrating datasets via the Rank Product method, and identified 375 up- and 66 down- regulated differentially expressed genes (DEGs). Notably, up-regulated genes were significantly associated with liver and kidney diseases. Using gene ontology enrichment, we found that the up-regulated DEGs were significantly enriched in the apoptotic process (false discovery rate, FDR=1.62e-10) and response to unfolded protein (FDR=7.65e-10). Protein-protein interaction networks identified the hub proteins containing HSP90AB1 and HSPA5. These findings suggest that our DEGs may provide a robust set of genetic markers for PCB77.

Keywords

Coplanar Polychlorinated biphenyls Meta-analysis Risk assessment Liver disease Kidney disease 
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Meta-analysis of microarray datasets for the risk assessment of coplanar polychlorinated biphenyl 77 (PCB77) on human health

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Copyright information

© Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Junghyun Jung
    • 1
  • Kyoungyoung Hah
    • 1
  • Woosuk Lee
    • 1
  • Wonhee Jang
    • 1
  1. 1.Department of Life ScienceDongguk UniversitySeoulRepublic of Korea

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