Hematocrit levels and arterial stiffness: the Cardiometabolic Risk in Chinese (CRC) Study
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We aimed to investigate the association of haematocrit (HCT) level with central and peripheral arterial stiffness in adults in China. We particularly focussed on the association between HCT and other cardiometabolic risk factors.
Adults aged ≥ 20 years were included in the study. Carotid radial pulse wave velocity (crPWV), carotid femoral pulse wave velocity (cfPWV), carotid dorsalis pedis pulse wave velocity (cdPWV), and HCT were measured.
Overall, 3225 individuals were included in the study. After adjustment for age, sex, and body mass index, HCT level was found to increase significantly with increases in cfPWV, crPWV, and cdPWV (p = 0.001). Following adjustment for heart rate, blood pressure, and blood lipids, the association of HCT level with crPWV and cdPWV was not significant (p = 0.090 and 0.053, respectively); however, the association between HCT level and cfPWV remained significant (p = 0.007). We found significant interactions of HCT level with hypertension and metabolic syndrome in the effect on cfPWV (p = 0.0419 and 0.026, respectively).
In adults in China, HCT level was associated with elevated central arterial stiffness, independent of conventional cardiovascular risk factors. As a serological marker, HCT can predict the degree of central arterial stiffness. HCT combined with other traditional cardiovascular risk factors can better assess vascular heart disease.
KeywordsHematocrit Pulse wave velocity Hypertension
carotid-radial pulse wave velocity
carotid-femoral pulse wave velocity
Carotid dorsalis pedis pulse wave velocity
Cardiometabolic Risk in Chinese
serum uric acid
fasting blood glucose;
high-density lipoprotein cholesterol
low-density lipoprotein cholesterol
We acknowledge and thank all participants for their cooperation and sample contributions.
Availability of data and materials
All data generated or analysed during this study are included in this manuscript.
CY Z and XK L were the performer of this study and written this manuscript; QQ Q performed the recruitment of patients; J L and HF G were the guarantor of integrity of the entire study and responsible for the study concepts, study design, and approval of the final version of the manuscript; L Q was responsible for the analysis the data onto this study.
This work was supported by (1) The Jiangsu Provincial Bureau of Health Foundation (grant no. H201356 and BRA2014058), (2) The Jiangsu Six Talent Peaks Program (No. 2013-WSN-013), (3) The Xuzhou Outstanding Medical Academic Leader Project and the Xuzhou Science and Technology Grants (nos. XM13B066 and KC14SX013), (4) The generous grants from Jiangsu Province Science and Education Project for Young Talent (QNRC2016388),and (5) The social development project of the Xuzhou Municipal Science and Technology Bureau (KC165W163).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was reviewed and approved by the ethics committee of the Central Hospital of Xuzhou, Affiliated Hospital of Medical School of Southeast University, China. (No. 2015.428).
Informed consent was obtained from all individual participants included in the study.
Consent for publication
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