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Hematocrit levels and arterial stiffness: the Cardiometabolic Risk in Chinese (CRC) Study

  • Caiyan Zou
  • Xuekui Liu
  • Qinqin Qiu
  • Jun LiangEmail author
  • Houfa GengEmail author
  • Lu Qi
Original Article
  • 4 Downloads

Abstract

Objective

We aimed to investigate the association of haematocrit (HCT) level with central and peripheral arterial stiffness in adults in China. We particularly focussed on the association between HCT and other cardiometabolic risk factors.

Methods

Adults aged ≥ 20 years were included in the study. Carotid radial pulse wave velocity (crPWV), carotid femoral pulse wave velocity (cfPWV), carotid dorsalis pedis pulse wave velocity (cdPWV), and HCT were measured.

Results

Overall, 3225 individuals were included in the study. After adjustment for age, sex, and body mass index, HCT level was found to increase significantly with increases in cfPWV, crPWV, and cdPWV (p = 0.001). Following adjustment for heart rate, blood pressure, and blood lipids, the association of HCT level with crPWV and cdPWV was not significant (p = 0.090 and 0.053, respectively); however, the association between HCT level and cfPWV remained significant (p = 0.007). We found significant interactions of HCT level with hypertension and metabolic syndrome in the effect on cfPWV (p = 0.0419 and 0.026, respectively).

Conclusions

In adults in China, HCT level was associated with elevated central arterial stiffness, independent of conventional cardiovascular risk factors. As a serological marker, HCT can predict the degree of central arterial stiffness. HCT combined with other traditional cardiovascular risk factors can better assess vascular heart disease.

Keywords

Hematocrit Pulse wave velocity Hypertension 

Abbreviations

HCT

hematocrit

crPWV

carotid-radial pulse wave velocity

cfPWV

carotid-femoral pulse wave velocity

cdPWV

Carotid dorsalis pedis pulse wave velocity

MetS

metabolic syndrome

CRC

Cardiometabolic Risk in Chinese

BMI

bodymass index

BP

blood pressure

HR

heart rate

SUA

serum uric acid

FBG

fasting blood glucose;

TC

total cholesterol

TG

triglycerides

HDL-C

high-density lipoprotein cholesterol

LDL-C

low-density lipoprotein cholesterol

Notes

Acknowledgments

We acknowledge and thank all participants for their cooperation and sample contributions.

Availability of data and materials

All data generated or analysed during this study are included in this manuscript.

Authors' contributions

CY Z and XK L were the performer of this study and written this manuscript; QQ Q performed the recruitment of patients; J L and HF G were the guarantor of integrity of the entire study and responsible for the study concepts, study design, and approval of the final version of the manuscript; L Q was responsible for the analysis the data onto this study.

Funding information

This work was supported by (1) The Jiangsu Provincial Bureau of Health Foundation (grant no. H201356 and BRA2014058), (2) The Jiangsu Six Talent Peaks Program (No. 2013-WSN-013), (3) The Xuzhou Outstanding Medical Academic Leader Project and the Xuzhou Science and Technology Grants (nos. XM13B066 and KC14SX013), (4) The generous grants from Jiangsu Province Science and Education Project for Young Talent (QNRC2016388),and (5) The social development project of the Xuzhou Municipal Science and Technology Bureau (KC165W163).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was reviewed and approved by the ethics committee of the Central Hospital of Xuzhou, Affiliated Hospital of Medical School of Southeast University, China. (No. 2015.428).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Consent for publication

None application.

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Copyright information

© Research Society for Study of Diabetes in India 2020

Authors and Affiliations

  1. 1.Department of EndocrinologyXuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast UniversityXuzhouChina
  2. 2.Xuzhou Institute of Medical Sciences, Xuzhou Institute of DiabetesXuzhouChina
  3. 3.Department of NutritionHarvard School of Public HealthBostonUSA

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