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Changes in SFRP5, WNT5A, HbA1c, BMI, PBF, and insulin resistance in men with type 2 diabetes after 12 weeks of combined exercise (HIIT and resistance)



Secreted frizzled-related protein 5 (SFRP5) and WNT family member 5A (WNT5A) have been found to associate with glucose metabolism and insulin sensitivity through noncanonical WNT signaling. The purpose of this study was to investigate changes in SFRP5, WNT5A, glycated hemoglobin (HbA1c), body mass index (BMI), percentage body fat (PBF), and insulin resistance in men with type 2 diabetes after 12 weeks of combined exercise (high-intensity interval training (HIIT) and resistance) and examine the relationship between these variables in men with type 2 diabetes.


Nineteen men with type 2 diabetes (mean age of 58.3) were divided into two groups: experimental group (10 individuals) and control group (9 individuals). The experimental group performed 12 weeks of combined exercise (HIIT and resistance).


Twelve weeks of combined exercise (HIIT and resistance) increased SFRP5 serum level and decreased WNT5A serum level, HbA1c, insulin resistance, BMI, and PBF in the intervention group compared with the control group. SFRP5 had a significant negative relationship with WNT5A, insulin resistance, BMI, and PBF. In addition, BMI had a significant positive relationship with WNT5A, insulin resistance, and PBF.


The improvement of type 2 diabetic men’s health can be a result of increased anti-inflammatory factor SFRP5 and decreased inflammatory factor WNT5A through reduction of BMI and PBF.

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Correspondence to Mahtab Moazzami.

Ethics declarations

This research was conducted following an intervention study design and was approved by the Regional Scientific Ethics Committee, Ferdowsi University of Mashhad, in accordance with the ethical standards of the 1983 Helsinki declaration. The subjects of this study were 19 men with type 2 diabetes aged 50–60 years, BMI 25–30 kg/m2, who voluntarily participated in the study after obtaining a written consent.

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The authors declare that they have no conflict of interest.

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Cite this article

Mir, E., Moazzami, M., Bijeh, N. et al. Changes in SFRP5, WNT5A, HbA1c, BMI, PBF, and insulin resistance in men with type 2 diabetes after 12 weeks of combined exercise (HIIT and resistance). Int J Diabetes Dev Ctries (2020).

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  • SFRP5
  • WNT5A
  • HbA1c
  • Exercise
  • Insulin resistance