HbA1c reduction and weight-loss outcomes: a systematic review and meta-analysis of community-based intervention trials among patients with type 2 diabetes mellitus
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Managing blood glucose and maintaining weight could prevent the risk of diabetes complications and maintain of T2DM. The study aimed to provide the systematic review and meta-analysis to test the effect of community-based interventions on HbA1c reduction and weight loss after receiving the community-based intervention and to determine any gaps in the literature and set up the recommendations for future intervention. Two databases PubMed and Medline were included to extract the relevant articles. “Type 2 diabetes (T2D),” “Community-Based Intervention,” “glycemic control,” and “weight reduction” were used as the keywords. Appraisal of systematic review was based on PRISMA format. Out of 475 publications identified, 12 studies that fulfilled inclusion criteria which characterized by predominantly measure HbA1c and weight were included in the meta-analysis. Overall, the community-based intervention decreased the HbA1c levels by − 0.25% (− 0.33, 0.16) and (Z = − 582, p = 0.00) and weight loss (Z = − 5.110, p = 0.00). The community-based intervention positively decreased the HbA1c level. Our findings could guide the significance of community-based interventions for T2DM patients in the future.
KeywordsDiabetes mellitus community-based intervention HbA1c reduction Weight loss
The authors would like to thank Mahidol University for facilitating the database search for conducting this review.
Our special thanks to the Indonesia Endowment Fund for Education (LPDP Scholarship) for study grant supports.
Compliance with ethical standard
The Endowment Fund (LPDP Scholarship of Indonesia) funded this study for Education with the grant number S-3937/LPDP.3/2016. However, we declare no conflict of interest in this manuscript. The funding sponsors also had no role in writing the manuscript or the decision to publish this manuscript. In addition, this article does not contain any studies with human subjects or animals performed by any of the authors. This study uses only the secondary data of Mahidol University databases.
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