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Effect of prenatal zinc supplementation on adipose tissue-derived hormones and neonatal weight, height and head circumference in women with impaired glucose tolerance test: randomized clinical controlled trial

  • Neda Roshanravan
  • Mohammad Alizadeh
  • Mohammad Asghari Jafarabadi
  • Naimeh Mesri Alamdari
  • Hamed Mohammadi
  • Nazila Farrin
  • Ali Tarighat-EsfanjaniEmail author
Original Article
  • 11 Downloads

Abstract

Background

It is well known that normal pregnancy exposes mothers to a diabetogenic state. The important role of adipose tissue in the regulation of insulin resistance has been repeatedly proven. This organ carries out the regulation of insulin resistance by producing adipocytokines involved in the pathogenesis of gestational diabetes mellitus (GDM). The present study aims to evaluate the effects of zinc supplementation on serum leptin, visfatin, tumor necrosis factor-α (TNF-α), adiponectin and zinc-α2-glycoprotein (ZAG) levels in pregnant women with impaired glucose tolerance test (IGTT) results.

Methods

In this randomized, placebo-controlled, double-blind clinical trial, 46 pregnant women with impaired glucose tolerance test results were randomly distributed into zinc (n = 23) and placebo (n = 23) groups and received 30 mg zinc supplement per day in the form of zinc gluconate and placebo, respectively, for 8 consecutive weeks. The study was conducted in the Shabestar district of northwestern Iran.

Results

Supplementation after adjusting for confounding variables resulted in a significant reduction in plasma leptin (p = 0.035) and TNF-α (p = 0.027) levels in the zinc group compared with the placebo group. Serum visfatin levels were significantly increased, and serum ZAG levels were significantly decreased in both groups. However, the changes in adiponectin concentration were not significant in either group after intervention nor were the anthropometric parameters in fetuses whose mothers received the zinc supplement.

Conclusions

It seems that zinc supplementation may be considered as a complementary supplement together with the medical management of patients with IGT or GDM. However, further studies are needed before definite conclusions can be drawn.

Keywords

Zinc Leptin Visfatin Zinc-–α2-glycoprotein Pregnancy 

Notes

Acknowledgements

This work was supported by the Research Vice-chancellor and Nutrition Research Center of Tabriz University of Medical Sciences. The participation of all patients in this study is gratefully acknowledged.

Funding/support

This work was supported by the Tabriz University of Medical Sciences [grant number: 91227].

Authors’ contribution

NR, ATE, NM, and MA performed the research and contributions to design of the study. NR prepared the primary draft. HM, NF, and MAJ: contribution to data analysis; ATE and MA: edited the final draft and final approval of the manuscript.

Compliance with ethical standards

All the participants filled in the informed written consent and the researcher got the ethical permission for the study from the ethics committee of Tabriz University of Medical Sciences. The current study is registered in the Iranian Registry of Clinical Trials (IRCT registration number: IRCT 201212265670 N6) and full trial protocol can be accessed in IRCT website.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study conformed to the 1964 Helsinki declaration and its later amendments. The study was approved by the ethics committee of Tabriz University of Medical Sciences.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Research Society for Study of Diabetes in India 2019

Authors and Affiliations

  • Neda Roshanravan
    • 1
    • 2
  • Mohammad Alizadeh
    • 3
  • Mohammad Asghari Jafarabadi
    • 4
    • 5
  • Naimeh Mesri Alamdari
    • 6
  • Hamed Mohammadi
    • 7
    • 8
  • Nazila Farrin
    • 2
  • Ali Tarighat-Esfanjani
    • 9
    Email author
  1. 1.Cardiovascular Research CenterTabriz University of Medical SciencesTabrizIran
  2. 2.Nutrition Research Center, Tabriz University of Medical Sciences, TabrizIran
  3. 3.Nutrition Research CenterTabriz University of Medical SciencesTabrizIran
  4. 4.Road Traffic Injury Prevention Research Center, School of HealthTabriz University of Medical SciencesTabrizIran
  5. 5.Department of Statistics and Epidemiology, Faculty of HealthTabriz University of Medical SciencesTabrizIran
  6. 6.Students Research Committee, School of HealthIran University of Medical SciencesTehranIran
  7. 7.Department of Clinical Nutrition, School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran
  8. 8.Student Research CommitteeIsfahan University of Medical SciencesIsfahanIran
  9. 9.Nutrition Research Center, School of NutritionTabriz University of Medical SciencesTabrizIran

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